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To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML patient cases here. Clinicians submit a brief history of the patient and the case for discussion (no more than 200 words) by posting it in this forum ("+ NEW TOPIC" button below).

Each clinical case will be forwarded to the iCMLf expert clinical panel for a brief independent response. Consideration should be given to patient confidentiality. Details that are not critical to the case can be changed to preserve anonymity.

As a full clinical history is necessary for accurate comment, cases and comments on the Forum are only accepted from clinicians. If individual patients have a specific question we encourage them to contact their healthcare provider.

DISCLAIMER: The iCMLf does not recommend or endorse any specific tests, physicians, products, procedures, or opinions, and disclaims any representation, warranty, or guaranty as to the same. Reliance on any information provided in this Forum is solely at your own risk.

TOPIC: Query blast crisis?

Query blast crisis? 3 weeks 5 days ago #1676

  • Saurabh Bhave
  • Saurabh Bhave's Avatar
We have a young male with muscle lesion which on biopsy is CML.
He is CML in CP on BM studies.
Cytogenetics: no other abnormalities other than PH chromosome

Is extramedullary CML (without any increase in blasts) be considered as blast crisis?

Regards
Saurabh

Query blast crisis? 3 weeks 5 days ago #1677

  • Giuseppe Saglio
  • Giuseppe Saglio's Avatar
To answer this question I have to go back to the opinion of John Goldman (as well as of other experts); extra-medullary CML has to be considered a progression and transformation of CML similar to blast crisis, in particular if the patient was already in TKI therapy. Is this the case?
Yours, Beppe Saglio
Last Edit: 3 weeks 4 days ago by Nicola.

Query blast crisis? 3 weeks 5 days ago #1678

  • jeff lipton
  • jeff lipton's Avatar
Agree with Bepe. If this is extramedullary disease, it should be considered like blast crisis. Would consider radiating the lesion and if otherwise responding to TKI, go to allografting in a young person
Last Edit: 3 weeks 4 days ago by Nicola.
Moderators: Melissa Davis-Bishop
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