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To answer this question I have to go back to the opinion of John Goldman (as well as of other experts); extra-medullary CML has to be considered a progression and transformation of CML similar to blast crisis, in particular if the patient was already in TKI therapy. Is this the case?
Yours, Beppe Saglio
Agree with Bepe. If this is extramedullary disease, it should be considered like blast crisis. Would consider radiating the lesion and if otherwise responding to TKI, go to allografting in a young person