Session 4: CML Related Topics
Chair: A/Prof Agnes Yong

• Management of Myelofibrosis
  (Dr David Ross)
• MDS/MPN Overlap Syndrome
  (Dr Devendra Hiwase)
• Pediatric CML
  (Dr Michael Osborn)

Management of Myelofibrosis
Dr David Ross, SA Pathology / Universities of Adelaide and South Australia

• COMFORT trials
• Dosing guidance
• Important toxicities
• Interrupting or stopping treatment
• Patient population outside COMFORT trials
  • INT-1 and low-risk
  • Pre- and post-transplant
• Other JAK inhibitors

MDS/MPN Overlap Syndrome
Dr Devendra Hiwase, SA Pathology / Royal Adelaide Hospital / SAHMRI

• How is MDS diagnosed?
• MDS/MPN overlap
• MDS/MPN's: WHO subtypes
• CMML: diagnostic criteria
• Cytogenetic abnomalities in CMML
• Common genetic mutations in CMML
• Current therapeutic strategies in CMML
• WHO diagnostic criteria for aCML
• Diagnosis of aCML
• Treatment algorithms for aCML
• Chronic neutrophilic leukemia

Pediatric CML
Dr Michael Osborn - Royal Adelaide Hospital

• CML is different in children and adults
• Clinical presentation is different in children and adults
• Adult prognostic scores do not apply to children
• Imatinib in children with CML
• Dasatinib in children with CML
• Nilotinib in children with CML
• What about stem cell transplant?
• Can we stop TKI in children with deep response?