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John Goldman: CML Treatment with imatinib

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Issues covered in this presentation:

  • Biology and mechanisms of CML
  • Mechanism of action of imatinib
  • Results of the IRIS study
  • Adverse effects of imatinib
  • Methods to detect residual disease
  • Imatinib in children and in pregnancy
 

 


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Michele Baccarani - European Leukemia Network (ELN) recommendations

Please click on the image to start the presentation. While watching the presentation, you can also click on each of the small slides to jump to the sections. We appreciate your feedback: Please rate the video with the radio buttons above, share your comments using comments box below, or share your ideas in our Discussion Forum. View the other Virtual Education Program modules.

 

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Issues covered in this presentation:

  • Predicting response to imatinib
  • Depth of response, does it matter?
  • Primary and secondary failure to imatinib
  • How to monitor response
  • Treatment recommendations

 


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Jorge Cortes - Treatment of patients after imatinib first line therapy

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Issues covered in this presentation:

  • Survival post imatinib
  • Treatment with 2nd generation TKIs (2nd line, 1st line)
  • Optimal time to switch therapy
  • Strategies to prevent imatinib failure
  • Role of interferon and transplantation
  • Presentation of new agents under investigation

 


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Please click on the image below to watch the webcast, and a window will open. You can then also click on the slides to jump to certain sections of the presentation.

We appreciate your feedback: Please rate the video with the radio buttons above, share your comments using comments box below, or share your ideas in our Discussion Forum. View the other Virtual Education Program modules.

 

Practical recommendations for the management of CML patients: Interview with Prof. Timothy Hughes

 

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Please click on the image below to watch the webcast, and a window will open. You can then also click on the slides to jump to certain sections of the presentation. We appreciate your feedback: Please rate the video with the radio buttons above, share your comments using comments box below, or share your ideas in our Discussion Forum. View the other Virtual Education Program modules.

 

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Issues covered in this presentation:

  • Definition of optimal response to imatinib
  • Suboptimal response
  • Considerations for managing suboptimal response, case study
  • Adherence and molecular response
  • Role of mutations, criteria for mutation screening on first line therapy
  • Dose related toxicities with TKI’s; concomitant medications

 


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Non-adherence of CML patients

Results of the global adherence survey of the CML Advocates Network
Giora Sharf, CML Advocates Network

 

Issues covered:

  • Results of the global adherence survey of 2546 CML patients from 79 countries
  • Intentional and non-intentional non-adherence levels
  • Differences between countries, type of TKI, administration schedule, age groups, perception of quality of life and side effects
  • Tools to drive adherence and importance of routine

 

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Facteur de variabilité de la réponse au ITK</li>
              <li>Les trois grand mécanismes de résistance</li>
              <li>La réponse au traitement</li>
              <li>Autres inhibiteurs de tyrosine kinase: le Nilotinib et le Dasatinib

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