I agree completely with Jorge. An urgent allograft is necessary if CP2 or even AP can be obtained. I notice that the only comment is about a cord blood. What about a haplo graft? Without a transplant, the response if any, is only transient. Would reduce the ponatinib dose to 30 during the chemo part (due to interaction with some of the drugs used during induction) and then increase immediately after to 45. Assuming the patient gets to a transplant, would withdraw immunosuppression in the absence of GVHD promptly, starting around day 45 and finishing within a couple of weeks. Would continue probably lifelong ponatinib post allograft starting around day 60 if off immunosuppression – first year at 45 and thereafter at 30 (due to long term chronic toxicity at 45), assuming toleration.
Biggest potential problem here is compliance. My experience in similar cases, is that patients who do not take TKIs are very often non-compliant in allograft related meds. Good luck.