CML Publications

To keep you up-to-date on the latest scientific findings and on the clinical management of CML the iCMLf is pleased to present to you monthly updates from key CML publications in peer-reviewed journals. 

This month's iCMLf 'Publications of the month' are brought to you by Professor Jerald Radich. From the many papers on CML published this month Professor Hughes has selected topical, interesting papers for your perusal including interesting articles from the emerging economic regions.

Read Professor Hughes' CML publications of the month: June 2019

We are pleased to present to you a special highlight this month: The iCMLf Global Genomic Alliance have our first published paper. Genomic studies have the potential to lay the foundation for improved diagnostic risk classification according to clinical and genomic risk, and to enable more precise early identification of TKI resistance¹. Published in Leukemia this review article examines the landscape of reported mutated cancer-associated genes in CML patients at various disease phases.

Read more about this first step for the Alliance on our way to finding a cure for CML:

¹Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia
Branford S et al. Leukemia, June 2019 (epub ahead of print)

Clinical publications

• De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukemia (DESTINY): a non-randomized, phase 2 trial
  Clark RE et al. Lancet Haematol, June 2019 (epub ahead of print)
  
  
• Treatment value of second-generation BCR-ABL1 tyrosine kinase inhibitors compared with imatinib to achieve treatment-free remission in patients with chronic myeloid leukemia: a modeling study
  Shih YT et al. Lancet Haematol, June 2019 (epub ahead of print)
  
  
• Beyond the comfort zone of deep molecular response: discontinuation in major molecular response chronic myeloid leukemia
  Dragani M et al. Leuk Lymphoma, June 2019 (epub ahead of print)
  
  
• Therapy de-escalation before stopping in chronic myeloid leukemia
  Mustjoki S et al. Lancet Haematol, June 2019 (epub ahead of print)

• Planned pregnancy in female patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy
  Dou X et al. Oncologist, June 2019 (epub ahead of print)

Scientific publications

• Gene expression signature that predicts early molecular response failure in chronic-phase CML patients on frontline imatinib
  Kok CH et al. Blood Adv, May 2019
  

• Outcomes of patients with chronic myeloid leukemia (CML-CP) after discontinuation of frontline ponatinib therapy
  Boddu P et al. Leuk Lymphoma, May 2019 (epub ahead of print)
  

• SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
  Abraham A et al. J Clin Invest, June 2019
  

Pediatric publications

• Large amplicon droplet PCR for DNA-based monitoring of pediatric chronic myeloid leukaemia
  Krumbholz M et al. J Cell Mol Med, June 2019 (epub ahead of print)