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We are pleased to make available a new series of presentations on various aspects of CML management that were first presented at the 22nd Meeting of the European Hematology Association (EHA) in Madrid in 2017. Modules currently featured include; how to treat CML in 2017, factors affecting clinical decision making in relapsed and refractory CP-CML patients and treatment outcomes of bosutinib from real-world data. 

 We are very grateful for the support of Brandcast media to produce these webstreams.
EHA Andreas Hochhaus

 

 

  

        

 

How to treat CML in 2017?
Andreas Hochhaus, Universitätsklinikum Jena, Germany 

  • Objectives of treatment optimization
  • Choice of initial therapy
  • Clinical data on 1st and 2nd generation TKI's
  • Comorbidities in CML at diagnosis
  • Main adverse events of TKI's
  • ELN recommendations for monitoring of first-line TKI therapy
  • Recommendations for switch: CP-CML
  • Management of blast crisis
  • Limitations of TKI therapies
  • Discussion: are we ready for routine stopping procedure?
  • Recommendations on CML management 2013 - 2017

This presentation is adapted from the one presented during the CML educational session at EHA. It lasts around 30 minutes.

 

EHA Delphine Rea

 

 

  

        

 

Factors affecting clinical decision making in refractory and relapsed CP-CML patients
Delphine Réa, Centre Hospitalo-Universitaire Saint-Louis, Paris, France

  • TKI resistance: significance and definition 
  • BCR-ABL1 mutations and resistance to imatinib and 2nd generation TKI's
  • Failure of 1st and 2nd generation TKI's
  • Mortality and causes of death in CP-CML patients during 2nd or subsequent line TKI
  • Responses to 3rd line therapy after resistance or intolerance to 2nd generation TKI
  • 5-year results from the PACE study: Responses to ponatinib in CP-CML patients
  • Therapeutic innovation: allosteric inhibition of BCR-ABL1 by ABL001
  • Conclusion and perspective

This presentation is adapted from one given during the industry sponsored symposium at EHA.

 

 
EHA Jane Apperley

 

 

  

        


Treatment Outcomes on Bosutinib: Data from the Real World
Jane Apperley, Imperial College, London, UK

  • Change in CML survival over time: German studies 
  • Patient pathways for tyrosine kinase inhibitors
  • Introduction of bosutinib into clinical practice
  • Real-World use of bosutinib: UK & Netherlands
  • Responses to bosutinib in chronic phase
  • Reasons for discontinuation of bosutinib
  • Disease progression
  • Adverse events on bosutinib
  • Overall survival
  • Summary and conclusions

This presentation is adapted from one given during the industry sponsored symposium at EHA.

-- Virtual Education Program: 2016 Edition

We are pleased to make available a new series of presentations on modern diagnostics in CML that were first presented at the 'Clinical Symposium on Modern Diagnostics' during the 18th John Goldman Conference on CML in Houston in 2016. Modules currently featured include; The role of cytogenetic monitoring in CML management, Molecular monitoring in CML, Mutation screening and Biomarkers and response monitoring beyond PCR. 

 

Jorge Cortes 2013                          

 

The role of cytogenetic monitoring in CML management
Jorge Cortes - MD Anderson Cancer Center, University of Texas

  • Cytogenetic evaluation in CML
  • Cytogenetic clonal evolution
  • Additional chromosomal abnormalities in CML
  • Response to TKI by additional chromosomal abnormalities
  • Cytogenetic abnormalities in PH(1) metaphases
  • Additional cytogenetic abnormalities in CML-CP on TKI
  • Additional cytogenetic abnormalitites in 5q-MDS
     

-- Virtual Education Program: 2015 Edition 

 

Presentations from a CML Opinion Leader Meeting

We are pleased to make available a new series of presentations from the COLT Meeting 2014, an annual CML Opinion Leader Training that took place in Adelaide (Australia). Modules currently featured include; high risk CML, optimizing therapy, front line therapy in CML chronic phase and new developments in CML - all presented by leaders in the field. 

David RossAgnes YONG w labcoat1

Dr David Ross            Dr Agnes Yong

 

Session 4: New developments in CML

  • Is CML a curable disease? 
    (Dr David Ross)
  • Transplant and immunotherapy in CML
    (Dr Agnes Yong)

 

Deborah White                                                                

 

 

 

Biomarkers and response monitoring beyond PCR?
Deborah White - SAHMRI, University of Adelaide

  • Predictive biomarkers
  • Cytokines, growth factors and chemokines: TGF and IL6
  • KIR2DS1 genotype and inferior cytogenetic response: SPIRIT1
  • CIP2A and response
  • Imatinib drug levels and compliance