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David Ross Devendra Hiwase Michael Osborn                    

Session 4: CML related topics
Chair: Dr David Ross

  • Myelofibrosis Management
    (Dr David Ross)
  • MPN/MDS Overlap Syndrome
    (Dr David Ross)
  • Pediatric CML
    (Dr Michael Osborn)



David Ross



Tailoring treatment for myelofibrosis
Dr David Ross - SA Pathology / University of South Australia

  • Scope of clinical problems in myelofibrosis
  • Transplantation
  • ELN 2018 guidelines
  • Ruxolitinib and COMFORT trials
  • Other JAK inhibitors
  • Patient Case
  • Symptom-based therapies
  • Key points


Devendra Hiwase  

MPN/MDS Overlap Syndrome
Dr Devendra Hiwase - SA Pathology / Royal Adelaide Hospital

  • MDS
    • The cardinal features of MDS
    • How is MDS diagnosed?
    • MDS/MPNs: WHO subtypes
  • CMML
    • CMML prognostic score
    • Current therapeutic strategies in CMML
  • aCML
    • Diagnosis of aCML
    • Treatment algorithm for aCML
  • Case study

Michael Osborn



Pediatric CML
Dr Michael Osborn - SA Pathology / Royal Adelaide Hospital

  • CML biology is different in children and adults
  • Clinical presentation is different in children and adults
  • Adult prognostic scores do not apply to children
  • Overview of clinical studies in pediatric CML
  • Imatinib is associated with impaired growth
  • Should we switch TKI in children?
  • Frontline approach in 2019?
  • Stem cell transplantation in pediatric CML
  • Can we stop TKI in children with deep response?