Session 4: CML related topics
Chair: Dr David Ross

• Myelofibrosis Management
  (Dr David Ross)
• MPN/MDS Overlap Syndrome
  (Dr David Ross)
• Pediatric CML
  (Dr Michael Osborn)

Tailoring treatment for myelofibrosis
Dr David Ross - SA Pathology / University of South Australia

• Scope of clinical problems in myelofibrosis
• Transplantation
• ELN 2018 guidelines
• Ruxolitinib and COMFORT trials
• Other JAK inhibitors
• Patient Case
• Symptom-based therapies
• Key points

MPN/MDS Overlap Syndrome
Dr Devendra Hiwase - SA Pathology / Royal Adelaide Hospital

• MDS
  • The cardinal features of MDS
  • How is MDS diagnosed?
  • MDS/MPNs: WHO subtypes
• CMML
  • CMML prognostic score
  • Current therapeutic strategies in CMML
• aCML
  • Diagnosis of aCML
  • Treatment algorithm for aCML
• MDS/MPN-RS-T
• Case study

Pediatric CML
Dr Michael Osborn - SA Pathology / Royal Adelaide Hospital

• CML biology is different in children and adults
• Clinical presentation is different in children and adults
• Adult prognostic scores do not apply to children
• Overview of clinical studies in pediatric CML
• Imatinib is associated with impaired growth
• Should we switch TKI in children?
• Frontline approach in 2019?
• Stem cell transplantation in pediatric CML
• Can we stop TKI in children with deep response?