The MD Anderson published their data in 2004 that assessed the results of imatinib for patients with variant Philadelphia chromosome (El-Zimaity et al, Br J Haematol, 2004:125;187-95). In a multivariate analysis, the variant Ph had no impact in response rate, overall survival or duration of response.

ORIGINAL CASE:
I found a case three-way Philadelphia translocation 46,xy, t (3;9;22) (p21;q34;q11.2). He has been prescribed imatinib 400 mg OD and is doing well apparently.

I want to know if he needs to switch to nilotinib, is there any guidelines showing which drug should the patient use?

Respected all! I am relatively new and has worked in lab mostly. I found a case three-way Philadelphia translocation 46,xy, t (3;9;22) (p21;q34;q11.2). He has been prescribed imatinib 400 mg OD and is doing well apparently.

I want to know if he needs to switch to nilotinib, is there any guidelines showing which drug should the patient use?

Nasir
PhD research student