Male 20 yrs old, was on gleevec 600mg od, wcc57.94, hb14, plts 338 2019. Same dose follow up till June 2021, wcc 4.14 n2.42 hb 13 plts 149 gleevec decreased to 200mg od. Aug 2021wcc 3.32 n 1.97 hb11.6 plts 92, continues on gleevec 200mg od. On 17.09.2021, plts 32, no gleevec was transfused with plts. 08.10.2021 wcc 36.7 n56% hb9.1 plts 58, BMA done showed CML In blast crisis, blasts 40%. Received 1 dose of cytarabine 100mg. On 22.10.2021 wcc 15.24 ig17.8 hb10.1 plts 21, was transfused with plts. Stuck with way forward for this patient. Please advise.