Global Research

Working with the world’s leading experts, we’re answering the unanswered questions in CML through first-class global research. 

Woman microscope

A Cure for CML

With the ultimate goal of curing CML, the iCMLf drives global research collaborations to accelerate progress in this critical field. As the prevalence of CML continues to rise - projected to surpass 3 million patients worldwide by 2040 - the need for a coordinated global effort is more urgent than ever. Led by clinicians and researchers at the forefront of CML care, the iCMLf leverages its unique global position to foster innovative and collaborative approaches, aiming to improve outcomes and ultimately achieve a cure.

Specific efforts focus on advancing precision medicine and developing safer, more effective treatment strategies. Central to these efforts are the iCMLf’s two Global Alliances:

iCMLf Genomics Alliance

This initiative enhances global collaboration on genomic data and sample exchanges to better understand the relationship between genetic abnormalities and patient outcomes. Its ultimate goal is to create a genome-based risk calculator for newly diagnosed CML patients, paving the way for personalised treatment plans. 

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iCMLf Treatment-Free-Remission Alliance

This alliance focuses on understanding the biological and molecular features of successful TFR. By maximizing successful TFR attempts and minimizing associated risks, it aims to improve quality of life for patients while reducing the burden of lifelong therapy.

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iCMLf Cure Consortium

In 2025, the iCMLf established a Working Group to look at a cure for CML more broadly. Led by renowned experts Professor Brian Druker, Professor Ravi Bhatia, and Professor Sin Ong Tiong, this group is dedicated to identifying and advancing the next steps toward curing CML. The remit of the iCMLf team is to develop novel strategies to cure 90% of patients within the next 10 years, and establish CML as the first blood cancer where cure is normative.

 

Other Research Initiatives

While we strive for a cure, every iCMLf research project and collaboration aims to enhance best practice treatment and improve outcomes. The iCMLf  supports leading researchers  to study the unanswered questions in CML s. Current projects include: Co management of CML and Hepatitis B, pediatric CML management, particularly in LMICs, Global Genomic Variation in CML and increasing data on pregnancy in CML. 

While we strive for a cure, every iCMLf project, every collaboration, every step along the way, improves the treatment of people with CML around the world.