Clinical Guidelines

CML practitioners need trusted, evidence-based information to support the best possible care for their patients. International therapeutic guidelines - developed by leading CML experts and grounded in the latest research - provide a reliable and independent foundation for clinical decision-making. Here you'll find easy access to key international CML guidelines, selected to help you navigate the complexities of CML management and deliver optimal patient care.

Doctor at Computer

Chronic Myeloid Leukemia NCCN Clinical Practice Guidelines

View the NCCN Guidelines on chronic myeloid leukemia (Version 2.2024 - February, 2024)
View the NCCN Guidelines 'Integrating new therapies for the treatment of chronic-phase CML' (November 2025)
View the NCCN Guidelines for Patients (Version 2026)
 

2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia

Apperley, J.F., Milojkovic, D., Cross, N.C.P. et al. Leukemia 39, 1797–1813 (2025).
View the full publication
See Professor Jane Apperley's overview
 

2023 European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia

Cross, N.C.P., Ernst T., Branford S. et al. Leukemia 37, 2150–2167 (2023)
View the full publication
 

Pediatric Guidelines

International pediatric chronic myeloid leukemia expert panel recommendations
Management of children and adolescents with chronic myeloid leukemia in chronic phase
Millot F et al. Leukemia, 2025 Apr;39(4):779-791
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International pediatric panel recommendations
Management of children and adolescents with chronic myeloid leukemia in blast phase
Sembill S et al. Leukemia, 2023;37:505–517
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Children's Oncology Group CML Working Group
Management of CML in children and adolescents
Athale U et al. Pediatr Blood Cancer 2019 Sep;66(9):e27827
View the full publication