Clinical Case Discussion Forum
To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML cases here. Physicians submit a brief history of the patient and the case for discussion using this forum.
TFR following presentation in CML - AP
Topic
TFR following presentation in CML - AP
was created by
Dr. Saurabh Bhave
Dr. Saurabh Bhave
India
06:05 17 May 2019
Dear Team,
20 year old male
diagnosed as CML in AP in January 2017
no comorbidities
Started on Dasatinib 140 mg /day
His RQ-PCR is 0 % since last 2 years
Is he a candidate for TRF ? If yes when ?
Regards
Dr.Saurabh Bhave
Tata Medical Center, Kolkata
The general agreement for patients whose AP is the form of presentation of CML is to go on with the TKI indefinitely if they achieve a good response, as it is the case with this patient. Given the patient’s high risk because of his CML phase, TKI discontinuation is not recommended, and treatment should be given indefinitely. One possibility would be to reduce dasatinib dose to 100 mg daily, taking into account the sustained good molecular response.