Clinical Case Discussion Forum
To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML cases here. Physicians submit a brief history of the patient and the case for discussion using this forum.
Three-way Philadelphia chromosome
Topic
Three-way Philadelphia chromosome
was created by
Dr Nasir Ahmad
Dr Nasir Ahmad
Pakistan
04:02 21 February 2019
Respected all! I am relatively new and has worked in lab mostly. I found a case three-way Philadelphia translocation 46,xy, t (3;9;22) (p21;q34;q11.2). He has been prescribed imatinib 400 mg OD and is doing well apparently.
I want to know if he needs to switch to nilotinib, is there any guidelines showing which drug should the patient use?
Nasir
PhD research student
The MD Anderson published their data in 2004 that assessed the results of imatinib for patients with variant Philadelphia chromosome (El-Zimaity et al, Br J Haematol, 2004:125;187-95). In a multivariate analysis, the variant Ph had no impact in response rate, overall survival or duration of response.