CML Publications April 2025

The face of Professor Tim Hughes
Professor Timothy Hughes

As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include interesting publications from low- and middle-income countries.

Clinical CML papers

Asciminib monotherapy in patients with chronic myeloid leukemia chronic-phase without BCR::ABL1 T315I treated with at least 2 prior tyrosine kinase inhibitors: Phase 1 final results
Hochhaus A et al. Leukemia, April 2025 (epub ahead of print)
open access publication

Asciminib in combination with imatinib, nilotinib, or dasatinib in patients with chronic myeloid leukemia in chronic or accelerated phase: Phase 1 study final results
Cortes JE et al. Leukemia, April 2025 (epub ahead of print)
open access publication

Olverembatinib in chronic myeloid leukemia – Review of historical development, current status, and future research
Kantarjian H et al. Cancer, April 2025

Successful treatment-free remission after ponatinib discontinuation in pretreated patients with chronic myeloid leukemia in chronic-phase
Haddad FG et al. Clin Lymphoma Myeloma Leuk, April 2025

CAR-T cell therapy in chronic myeloid leukemia patients with lymphoid blast crisis: A multicenter clinical analysis
Liu Y et al. Cancer Lett, April 2025 (epub ahead of print)

Prognostic scoring system in chronic myeloid leukemia – Review
Lauseker M et al. Leukemia, April 2025 (epub ahead of print)
open access publication

How I individualize treatment for chronic-phase CML
Leyte-Vidal AM and Shah NP. Blood, April 2025 (epub ahead of print)

Synergistic effect of asciminib with reduced doses of ponatinib in human Ph+ myeloid leukemia with the T315M mutation
Nguyen T et al. Int J Hematol, April 2025 (epub ahead of print)
open access publication

Tyrosine kinase inhibitor treatment patterns in patients with chronic-phase chronic myeloid leukemia: A single centre data from China
Yuan MY et al. Clin Lymphoma Myeloma Leuk, April 2025

Scientific CML papers 

SMAC mimetics in action in chronic myeloid leukemia
Turhan AG. Blood, April 2025

SETD2 loss of function is a recurrent event in advanced-phase chronic myeloid leukemia and contributes to genomic instability
Mancini M et al. Clin Transl Med, April 2025
open access publication

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukemia
Kamizela AE et al. Nature, April 2025
open access publication

LMIC CML papers

Allogeneic transplantation for CML blast phase learnings over last decade from a single centre in North India
Patra PC et al. Ann Hematol, April 2025 (epub ahead of print)
open access publication

Effect of imatinib mesylate on the ovarian reserves of female patients with chronic myeloid leukemia
Satija T et al. Indian J Hematol Blood Transf, April 2025

The Influence of the COVID-19 Pandemic in NK Cell Subpopulations from CML Patients Enrolled in the Argentina Stop Trial
Belén Sanchez M et al. Cells, April 2025
open access publication