CML Publications of the Month
As part of our monthly news service we would like to make you aware of important CML publications. From the many papers published in May, Professor Timothy Hughes has selected topical, interesting papers for your perusal. Papers with a clinical, scientific, pediatric and low and middle income country focus are shared.
June 2026
Clinical CML papers
Second-line bosutinib for chronic phase chronic myeloid leukemia after imatinib: final, 10-year results of a phase I/II study
Gambacorti-Passerini C et al. Haematologica, June 2026 (epub ahead of print)
– open access publication
Longitudinal changes in body weight and body mass index in patients with chronic-phase chronic myeloid leukemia with tyrosine kinase inhibitors: A retrospective observational study
Alshurafa A et al. Oncology, June 2026 (epub ahead of print) – open access publication
Asciminib provides better efficacy and favorable safety and tolerability profile against investigator-selected tyrosine kinase inhibitors in East Asian patients with newly diagnosed chronic myeloid leukemia: Results from a subgroup analysis of the pivotal ASC4FIRST Study
Takahashi N et al. Cancer Med, June 2026 – open access publication
What is the optimal threshold for aberrant lymphoblasts at diagnosis to predict lymphoid transformation in chronic myeloid leukemia?
Jiang Z et al. Cytometry B Clin Cytom, June 2026 (epub ahead of print)
A survey on the management of chronic myeloid leukemia in chronic phase from the perspectives of both patients and physicians
Eşkazan AE et al. Ann Hematol, June 2026 (epub ahead of print)
Impact of somatic mutations on treatment response and resistance in chronic myeloid leukemia
Mishra S et al. Int J Hematol, June 2026 (epub ahead of print)
Comprehensive molecular characterization of treatment-free remission and molecular relapse in chronic myeloid leukemia patients: the EURO-SKI Biomarker Study
Rinaldetti S et al. Leukemia, June 2026 (epub ahead of print) – open access publication
Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML
Takahashi N et al. Blood Adv, June 2026 (epub ahead of print)
Early predictors of MR4.5 attainment and eligibility after TKI discontinuation in CML treated with second-generation TKIs
Ono T et al. Blood Adv, June 2026 (epub ahead of print)
Response-adapted dasatinib de-escalation strategy compared to upfront low-dose dasatinib: A prospective cohort study
Halder R et al. Leuk Res, June 2026
Scientific CML papers
Direct measurement of in vivo BCR::ABL1 kinase inhibition reveals stronger potency of asciminib compared with imatinib and nilotinib
Kok CH et al. Leukemia, June 2026 (epub ahead of print) – open access publication
Multicolor detection of chronic myeloid leukemia stem cells, including novel marker CD69, predicts survival and early hematological toxicity
Culen M et al. Haematologica, June 2026 (epub ahead of print) – open access publication
Localization of p210 BCR-ABL to the mitochondria promotes chronic myeloid leukemia cell proliferation through cIAP signaling
Ikegami A et al. FASEB J, June 2026
Prolonged BCR::ABL1 induction in the SCL-tTA mouse recapitulates gene expression signatures and therapeutic vulnerabilities of primary imatinib-resistant chronic myeloid leukemia
Shyamsunder P et al. Leukemia, June 2026 (epub ahead of print)
Pediatric CML papers
Prepubertal initiation of imatinib is associated with reduced final height in children with chronic myeloid leukemia
Sadanand R et al. Pediatr Hematol Oncol, June 2026 (epub ahead of print)
LMIC CML papers
Chronic myeloid leukemia in low- and middle-income countries
Mahon FX et al. N Engl J Med, June 2026
Chronic myeloid leukemia in resource-limited settings: Navigating treatment challenges amit limited tyrosine kinase inhibitor access
Aamir Z et al. J Int Med Res, June 2026 – open access publication
Benefits and perils of generic drugs for hematologic neoplasms and their use in low- and middle-income countries: a narrative review
Malhotra H. and Burli A., Blood Global Hematology, June 2026 – open access publication