CML Publications January 2026

The face of Professor Tim Hughes
Professor Timothy Hughes

As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include interesting publications from low- and middle-income countries.

Clinical CML papers

Randomized phase 3 trial of Ropeginterferon alpha-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX)
Burchert A et al. Leukemia, January 2026 (epub ahead of print)
open access publication

Ponatinib for CML patients in routine clinical practice: the PONDEROSA study
Schenk T et al. Ann Hematol, January 2026
open access publication

Risk factors and reasons for switching from front-line therapy in the Italian CML network: A cohort study
Breccia M et al. Br J Haematol, January 2026 (epub ahead of print) 

Treatment-free remission after two nilotinib consolidation durations in chronic myeloid leukemia treated with imatinib: Phase 3 ENESTPath results
Réa D et al. Leukemia, January 2026 (epub ahead of print)

Management of chronic myeloid leukemia during pregnancy: Review of evidence and treatment algorithm
Haddad FG et al. Clin Lymphoma Myeloma Leuk, January 2026

Real-world outcomes with low-dose dasatinib (50 mg) in imatinib-resistant chronic myeloid leukemia chronic-phase: A retrospective analysis of efficacy and safety
Gangadaran N et al. Cancer Rep (Hobokken), January 2026 
open access publication

Evaluating the safety of combining tyrosine kinase inhibitors with anticoagulants in chronic myeloid leukemia: A systematic review
Gameil A et al. Oncology, January 2026 (epub ahead of print) 
open access publication

One-year consolidation with ponatinib 15 mg in chronic myeloid leukemia on deep molecular response with imatinib
Pérez-Lamas L et al. Ann Hematol, January 2026 – open access publication 

Prediction of relapse after discontinuation of tyrosine kinase inhibitor treatment in chronic myeloid leukemia
Ross DM. Leuk Lymphoma, January 2026 (epub ahead of print) 

Introduction to a How I Treat series on chronic myeloid leukemia
Gotlib J. Blood January 2026 

How I treat advanced phases of CML
Mauro MJ. Blood, January 2026

How I evaluate and treat resistance and relapse in CML
Soverini S and Castagnetti F. Blood, January 2026 

How I individualize frontline treatment for chronic phase CML
Leyte-Vidal A and Shah NP. Blood, January 2026

How I approach hematopoietic stem cell transplantation for CML in a TKI world
Chalandon Y et al. Blood, January 2026

How I manage chronic myeloid leukemia during pregnancy 
Abruzzese E, Chelysheva E. Blood January 2026

Advances of next-generation STAMP inhibitors in chronic myeloid leukemia
Costa A and Breccia M. Expert Opin Investig Drugs, January 2026  

Drug resistance in chronic myeloid leukemia: The involvement of Galectin-1 and Galectin-3
Yildirim C. Mol Biol Rep, January 2026 

Sequential BCR::ABL1 evaluation during dose de-escalation in peripheral blood is more predictive of TFR success than single assessment at dose de-escalation in either peripheral blood or bone marrow
Patterson SD et al. Leukemia, January 2026 (epub ahead of print) 
open access publication

Scientific CML papers 

Hsp-70 Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells
Song T et al. Stem Cell Reports, January 2026 
open access publication

Pediatric CML Papers

How I treat chronic myeloid leukemia in children and adolescents
Chen J et al. Blood, January 2026

Predictors of response to imatinib therapy and long-term outcomes in pediatric and adolescent patients with chronic myeloid leukemia
Saha S et al. Cancer Rep (Hobokken), January 2026 
– open access publication

LMIC CML Papers

Next-generation sequencing from chronic myeloid leukemia dried blood spots: Insights and implications for global oncology
Oehler VG et al. Leukemia, January 2026 (epub ahead of print)

Impact of bone marrow fibrosis on the outcomes of chronic myeloid leukemia treated with second generation tyrosine kinase inhibitors
Fayyaz F et al. Indian J Hematol Blood Transfus, January 2026