CML Publications August 2025

As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include interesting publications from low- and middle-income countries.

Clinical CML papers

Asciminib remained superior versus bosutinib in late-line CML-CP after nearly 
4 years of follow-up in ASCEMBL
Mauro MJ et al. Blood Adv, August 2025 – open access publication

Venetoclax in combination with ponatinib for the treatment of asciminib-resistant chronic myeloid leukemia
Curik N et al. Leukemia, August 2025 (epub ahead of print) 
open access publication

Tyrosine kinase inhibitor discontinuation and reinitiation patterns in CML patients in the US: Real-world experience
Sarker J et al. Leuk Lymphoma, August 2025

Treatment-free remission in chronic myeloid leukemia patients with accelerated phase or tyrosine kinase inhibitor therapy failure
Yuan M et al. Br J Haematol, August 2025 (epub ahead of print) 
open access publication

Cardiovascular disease in patients with chronic myeloid leukemia: JACC: CardioOncology State-of-the-Art Review
Aghel N and Lipton JH. JACC CardioOncol, August 2025
open access publication

Outcome of chronic myeloid leukemia patients not in deep molecular response: Results from the GIMEMA LabNet CML Network database
Stagno F et al. Am J Hematol, August 2025 
open access publication

Real-world outcomes in patients with Philadelphia-chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia treated with ponatinib – 
Final 6-year results from a Belgian registry
Devos T et al. Hematology, August 2025 (epub ahead of print) 
open access publication

How I manage chronic myeloid leukemia during pregnancy
Abruzzese E and Chelysheva E. Blood, August 2025 (epub ahead of print)

Outcomes and patterns of relapse with ponatinib-based therapy in patients with chronic myeloid leukemia in blast phase
Karrar O et al. Leuk Lymphoma, August 2025 (epub ahead of print)

Indolent chronic myeloid leukemia – a historical dinosaur?
Lipton JH. Leuk Lymphoma, August 2025 (epub ahead of print)

Unusually indolent CML: Absence of complete cytogenetic response after 10 years of tyrosine kinase inhibitor therapy
Shen Q et al. Clin Lymphoma Myeloma Leuk, August 2025
open access publication

Evaluating a predictive model of tyrosine kinase inhibitor therapy failure in a European-type cohort: A step towards population-specific tools
Moinard S et al. Leukemia, August 2025 (epub ahead of print) 
open access publication

Asciminib in late-line CML treatment
Sweet K and Pinilla-Ibarz J. Blood Adv, August 2025 
open access publication

Scientific CML papers 

Flow cytometric detection of BCR::ABL1 in T-lymphocytes in chronic myeloid leukemia
Buic D et al. Pathology, August 2025
open access publication

T cell receptor mimic CAR T cells targeting cathepsin G signal peptide
Yan J et al. Leukemia, August 2025

Pediatric CML papers

Complications at diagnosis of pediatric chronic myeloid leukemia in chronic phase
Roy Moulik N et al. Pediatr Blood Cancer, August 2025 (epub ahead of print)
open access publication