As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include interesting publications on pediatric CML and articles on COVID-19 and CML.

We are delighted to share our new paper - Challenges in Management of Pediatric Chronic Myeloid Leukemia (pCML) in the Low-Middle Income Countries (LMICs): Insights from an International CML Foundation (iCMLf) Multi-National Survey.

The survey sheds light on patient, physician, and infrastructure challenges, urging the need for context-specific guidelines, advocacy for continuous TKI access, and improvements in diagnostic resources. 

Read Professor Hughes' CML publications of the month: January 2024

Clinical CML papers

• Arterio-occlusive events among patients with chronic myeloid leukemia on tyrosine kinase inhibitors
  Velmaat L and Cortes J. Blood, January 2024 (epub ahead of print)
• Dose modification dynamics of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) from the PACE and OPTIC trials
  Jabbour E et al. Leukemia, January 2024 (epub ahead of print) – open access publication
• Maximizing the value of chronic myeloid leukemia management using tyrosine kinase inhibitors in the USA: Potential determinants and consequences of healthcare resource utilization and costs, with proposed optimization approaches
  Lipton JH. Clin Drug Investig, January 2024 (epub ahead of print)
• How to interpret the EURO-SKI study and its treatment-free remission outcome. Reply to J.P Gale and J. Chen
  Pfirrmann M et al. Leukemia, January 2024 (epub ahead of print) – open access publication
  
• Treatment-free remission after a second TKI discontinuation attempt in patients with chronic myeloid leukemia re-treated with Dasatinib – Interim results from the DAstop2 trial
  Flygt H et al. Leukemia, January 2024 (epub ahead of publication) – open access publication
  
• Safety and efficacy of asciminib in a chronic myloid leukemia patient with chronic kidney disease: A case report
  Alshurufa A et al. Case Rep Oncol, January 2024 – open access publication
• A review of the therapeutic role of bosutinib in chronic myeloid leukemia – Review
  Kantarjian HM et al. Clin Lymphoma Myeloma Leuk, January 2024
• Safety and efficacy of tyrosine kinase inhibitors in very elderly patients (≥ 75 years) with chronic myeloid leukemia
  Costa A et al. J Clin Med, January 2024 – open access publication
• Philadelphia chromosome-positive B cell acute lymphoblastic phase arising 24 years after treatment-free remission for chronic myeloid leukemia with identical BCR-ABL fusion transcript
  Dereme J et al. Ann Hematol, January 2024 (epub ahead of print)
• What do atomic bomb survivors teach us about treatment-free remission in people with chronic myeloid leukemia
  Radivoyevitch T et al. Leukemia, January 2024 – open access publication
• How to individualized therapy after failing milestones in chronic myeloid leukemia: weighting late response and early death from CML against risk of alternative therapy
  Hehlmann R and Lauseker M. Leukemia, January 2024 (epub ahead of print) – open access publication
• Combinatorial treatment options for highly resistant compound mutations in the kinase domain of the BCR::ABL fusion gene in Ph-positive leukemias
  Sponseiler I et al. Am J Hematol, January 2024 – open access publication

Scientific CML papers

• Activating p53 abolishes self-renewal of quiescent leukemic stem cells in residual CML disease
  Scott MT et al. Nat Commun, January 2024 – open access publication
• Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model
  Imeri J et al. Front Immunol, January 2024 – open access publication

Pediatric CML papers

• Challenges in management of pediatric chronic myeloid leukemia (pCML) in the low- and middle income countries (LMICs’): Insights from an International CML Foundation (iCMLf) Multi National Study
  Roy Moulik N et al. Pediatr Hematol Oncol, January 2024 (epub ahead of print)
• Pediatric chronic myeloid leukemia P190 variant with IgA vasculitis: Rare association – case report
  Shah K et al. Pediatr Blood Cancer, January 2024

COVID-19 + CML

• The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey
  El-Ashwah S et al. Leuk Lymphoma, January 2024 (epub ahead of print) – open access publication