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CML is a rare cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. With the average age of diagnosis of CML being around 60 in western countries, CML in children is considered an ultra-rare condition.

Read more about pediatric CML here.


logo_cmladvocates_106The CML Advocates Network is both a virtual network and internet platform for patient organisations supporting patients and relatives affected by Chronic Myeloid Leukaemia (CML). Launched in 2007 with 4 founding member groups, it has now grown to a network of 131 leukaemia patient groups from 96 countries on all continents, offering support by sharing of best practice, information and advice for CML patient representatives.

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On the iCMLf Knowledge Centre - an interactive online resource developed by International CML experts from the iCMLf, there is a module on pediatric CML.

Chaired by Professor Meinolf Suttorp and Professor Nirmalya Roy Moulik, this module outlines a comprehensive review of the treatment of pediatric CML. You can acces the presentations here that cover all relevant aspects of pediatric CML:

  1. Difference between adult and pediatric CML (Dr Deepam Pushpam, India)
  2. Predisposition and genetic factors in pediatric CML (Professor Markus Metzler, Germany)
  3. Management of pediatric CML in the resource-restrained setting (Dr Nirmalya Roy Moulik India)
  4. Treatment recommendations for pediatric CML - Chronic phase (Professor Frédéric Millot, France)
  5. Treatment recommendations in pediatric CML - Blast phase (Dr Stephanie Sembill, Germany)
  6. Treatment-free remission in pediatric CML (Professor Nobuko Hijiya, USA)
  7. Tyrosine kinase inhibitor toxicity in pediatric CML (Dr Maaike Luesink, The Netherlands)
  8. Parenting in children with CML (Professor Meinolf Suttorp, Germany)
  9. Impact of tyrosine kinase inhibitors on growth and endocrine function in children with CML
    (Professor Meinolf Suttorp, Germany)

Access additional modules on the iCMLf Knowledge Centre here.

Please see below for a selection of interesting articles on pediatric CML in peer-reviewed journals.

We are delighted to share our new paper:

Challenges in management of pediatric chronic myeloid leukemia (pCML) in the low- and middle income countries (LMICs’): Insights from an International CML Foundation (iCMLf) Multi National Study
Roy Moulik N et al. Pediatr Hematol Oncol, January 2024 (epub ahead of print)

The survey sheds light on patient, physician, and infrastructure challenges, urging the need for context-specific guidelines, advocacy for continuous TKI access, and improvements in diagnostic resources.

Other latest publications include:

Search here for more publications on pediatric CML

Our 'Clinical Case Discussion Forum' features a number of discussions on pediatric CML cases. If you are a physician treating pediatric CML patients, please join our forum and get in touch with other experts.

The latest postings on pediatric CML include:

A number of clinical trials and research activities are currently ongoing to research pediatric CML.
Find more information here.