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CML Guidelines

CML practitioners need dependable, well researched information to help make the best decisions for their CML patients. International therapeutic guidelines on the management of CML based on the latest research and written by leading CML experts provide a reliable and independent source of information. 

This section provides access to a selection of relevant international CML guidelines designed to assist you in the management of your CML patients. These guidelines include: 

  • 2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia
  • European LeukemiaNet laboratory recommendations for the diagnosis and management of CML
  • NCCN Clinical Practice Guidelines in Oncology: CML version 2.2024
  • NICE - National Institute for Health and Care Excellence Guidances
  • Chronic myeloid leukemia ESMO clinical practice guidelines for diagnosis, treatment and follow-up 2017
  • Guidelines and recommendations for pediatric CML

If you have additional information to provide, please contact us at info@cml-foundation.org

2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia

Apperley JF et al. Leukemia 2025
Jul 11;39(8):1797–1813.

Click here to see the 2025 recommendations

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia

Cross NCP et al. Leukemia 2023 Nov;37(11):2150-2167

Click here to see the laboratory recommendations

Chronic Myeloid Leukemia NCCN Clinical Practice Guidelines

Click here to view the NCCN Guidelines
(Version 2.2024 - February, 2024)

Click here to view the NCCN Guidelines for Patients
(Version 2025)

NICE - National Institute for Health and Care Excellence

NICE Guidance: Asciminib for treating myeloid leukemia after 2 or more tyrosine kinase inhibitors
Published August 2022

Click here to view the full guidance

Click 'Read more'  to find more NICE guidances

ESMO Guidelines

Chronic Myeloid Leukemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up

Hochhaus A et al.
Ann Oncol
2017 Jul 1;28(suppl_4):iv41-iv51

Click here to view the full publication


Pediatric Guidelines

International pediatric chronic myeloid leukemia expert panel recommendations
Management of children and adolescents with chronic myeloid leukemia in chronic phase
Millot F et al. Leukemia, 2025 Apr;39(4):779-791
Click here to view the full publication

International pediatric panel recommendations

Management of children and adolescents with chronic myeloid leukemia in blast phase
Sembill S et al. Leukemia, 2023;37:505–517
Click here to view the full publication