Michele Baccarani - European Leukemia Network (ELN) recommendations

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Issues covered in this presentation:

• Predicting response to imatinib
• Depth of response, does it matter?
• Primary and secondary failure to imatinib
• How to monitor response
• Treatment recommendations

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Jorge Cortes - Treatment of patients after imatinib first line therapy

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Issues covered in this presentation:

• Survival post imatinib
• Treatment with 2nd generation TKIs (2nd line, 1st line)
• Optimal time to switch therapy
• Strategies to prevent imatinib failure
• Role of interferon and transplantation
• Presentation of new agents under investigation

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Practical recommendations for the management of CML patients: Interview with Prof. Timothy Hughes

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Issues covered in this presentation:

• Definition of optimal response to imatinib
• Suboptimal response
• Considerations for managing suboptimal response, case study
• Adherence and molecular response
• Role of mutations, criteria for mutation screening on first line therapy
• Dose related toxicities with TKI’s; concomitant medications

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