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What is paediatric Chronic Myeloid Leukemia (CML)?

CML is a rare cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. With the average age of diagnosis of CML being around 60 in western countries, CML in children is considered an ultra-rare condition. Read more about paediatric CML here.

Patient organisations supporting pediatric CML patients and their family members

logo_cmladvocates_106The CML Advocates Network is both a virtual network and internet platform for patient organisations supporting patients and relatives affected by Chronic Myeloid Leukaemia (CML). Launched in 2007 with 4 founding member groups, it has now grown to more than 90 leukaemia patient groups in more than 68 countries on all continents, offering support by sharing of best practice, information and advice for CML patient representatives.

Read more ...

Publications on pediatric CML

Please see below for a selection of interesting articles on pediatric CML in peer-reviewed journals. Latest publications include:

 

  • Prognostic discrimination based on the EUTOS long term survival score within the international registry for chronic myeloid leukemia in children and adolescents
    (Millot F et al. Haematologica, August 2017)
    (epub ahead of print)
  • The complexity of growth failure in children receiving tyrosine kinase inhibitor therapy for chronic myelogenous leukemia
    (Samis J et al. Pediatr Blood Cancer, July 2017) 
    (epub ahead of print)
  • Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents
    (Millot F. et al. Cancer, May 2017)
    (epub ahead of print)
  • Death within 1 month of diagnosis in childhood cancer: an analysis of risk factors and scope of the problem
    (Green A et al. J Clin Oncol, March 2017)
    (epub ahead of print)

 

Search here for more publications on pediatric CML 

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Online case discussions in the iCMLf Forum

Our online discussion forum "Difficult CML Cases" features a number of discussions on pediatric CML cases. If you are a physician treating pediatric CML patients, please join our forum and get in touch with other experts.

The latest postings on pediatric CML are:

  • 2nd transplant for 16 year old boy
    • last post by Timothy Hughes 
    • 3 months ago
  • Child with CML on dasatinib rising quant PCR 
    • last post by gsaglio
    • 11 months ago

Review articles on pediatric CML

Ongoing Clinical Trials on Pediatric CML

A number of clinical trials and research activities are currently ongoing to research pediatric CML. Find more information here.