The data relating to men on tyrosine kinase inhibitors who wish to have children is relatively limited, and is better for imatinib, dasatinib and nilotinib than bosutinib and ponatinib
There are two issues, fertility (the ability to conceive) and the potential impact on the child
We do not think the TKI impact male fertility. These data come from animal experiments and the fact that many men have had children while taking TKI. You say that your patients fertility has been affected but do you know it was better at diagnosis?
There is, to date, no suggestion that the TKI taken by men, have any detrimental effect on the foetus or the infant in terms of congenital abnormalities or later development
Jane