I believe that in any resistant, and particularly unusual, case, it is very important to know more. More tests require more money, but never as much as a wrong treatment decision. And forgetting money, a wrong treatment decision is not good for the patient. Therefore I confirm that a bone marrow examination, cytology, histopathology, and karyotype, would help. And I confirm that in the meantime I would test again imatinib, full dose.
Regards, Michele Baccarani