By definition, the presence of a granulocytic sarcoma means blast crisis. Therefore, this person has progressed on therapy and the initial Sokal and the molecular improvement should not define the future treatment. Patient needs at least a change in TKI, and perhaps chemotherapy plus new TKI, after reassessment. Morphology of the GS may also be important. If it is just chronic CML appearing, then new TKI alone may be adequate. If it actually looks like myeloid or lymphoid acute leukemia, then I would seriously suggest chemo plus TKI. Dasatinib is appropriate. Local radiation if that is the only site makes sense. Stem cell allografting whether this is related or unrelated needs to be done if the option exists. Also consider post allograft TKI as well.