CML publications 2021

Clinical Publications	Scientific Publications
December 2021
Emerging concepts for assessing and predicting treatment-free remission in chronic myeloid leukemia patients Breccia M et al. Expert Rev Hematol, December 2021 (epub ahead of print)	Shedding light on targeting chronic myeloid leukemia stem cells Houshmand M et al. J Clin Med, December 2021 – open access publication
Low-dose dasatinib in older patients with chronic myeloid leukemia in chronic phase (DAVLEC): a single-arm, multicentre, phase 2 trial Murai K et al. Lancet Haematol, December 2021	Antimetabolic cooperativity with the clinically approved L-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells Trinh A et al. Mol Metab, December 2021 – open access publication
Low-dose dasatinib: when less can be more Amrein PC. Lancet Haematol, December 2021	Description of PTPRG genetic variants identified in a cohort of chronic myeloid leukemia patients and their ability to influence response to tyrosine kinase inhibitors Ismail MA et al. Gene, December 2021 (epub ahead of print) – open access publication
Blast and accelerated phase CML: room for improvement How J et al. Hematology Am Soc Educ Program, December 2021 – open access publication	Quantitative proteomic analysis of plasma exosomes to identify the candidate biomarker of imatinib resistance in chronic myeloid leukemia patients Li MY et al. Front Oncol, December 2021 – open access publication
Matchpoint: the game is not over for blast-phase chronic myeloid leukemia Rousselot P. Lancet Hematol, December 2021 (epub ahead of print)	Large-scale topological disruption of chromosome territories 9 and 22 is associated with nonresponse to treatment in CML Fabian-Morales E et al. Int J Cancer, December 2021 (epub ahead of print) – open access publication
Chronic myeloid leukemia, BCR-ABL1-positive, carrying NPM1 mutation – First case series from a single institution Young PE et al. Leuk Res, December 2021	Screening and identification of key genes in imatinib-resistant chronic myelogenous leukemia cells: a bioinformatics study Zhang H et al. Hematology, December 2021 – open access publication
TKI discontinuation in CML: how do we make more patients eligible? How do we increase the chances of a successful treatment-free remission? Hochhaus A and Ernst T. Hematology Am Soc Hematol Educ Program, December 2021 - open access publication	Neutrophil extracellular traps are increased in chronic myeloid leukemia and are differently affected by tyrosine kinase inhibitors Telerman A et al. Cancers(Basel), December 2021 – open access publication
Lifelong TKI therapy: how to manage cardiovascular and other risks Mauro MJ. Hematology Am Soc Hematol Educ Program, December 2021 – open access publication	A bis-pyridinium fullerene derivative induces the generation of ROS in BCR-ABL-positive leukemia cells Sumi K et al. Eur J Pharmacol, December 2021 (epub ahead of print)
Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-crisis chronic myeloid leukemia (MATCHPOINT): a single-arm, multicentre phase 1/2 trial Copland M et al. Lancet Haematology, December 2021 (epub ahead of print)	Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/AKT pathway attenuation and Myc downregulation Ding L et al. Eur J Pharmacol, December 2021
Efficacy and safety following bosutinib dose reduction in patients with Philadelphia chromosome-positive leukemias Kota V et al. Leuk Res, December 2021	SOCS-2 gene expression at diagnosis does not predict for outcome of chronic myeloid leukemia patients on imatinib treatment Egeli DB et al. Leuk Lymphoma, December 2021 (epub ahead of print)
Chronic myeloid leukemia stem cells targeting therapeutic implications Mojtahedi H et al. Stem Cell Res Ther, December 2021 – open access publication	The effect of Gö6976 on chronic myeloid leukemia in vitro and in vivo Cao ZR et al. Hematology, December 2021
BCR-ABL1 p210 screening for chronic myeloid leukemia in patients with peripheral blood cytoses Fenu E et al. Int J Lab Hematol, December 2021	Potential approaches versus approved or developing chronic myeloid leukemia therapy Andretta E et al. Front Oncol, December 2021 – open access publication
Clinical outcome of chronic myeloid leukemia patients who switch from first-line therapy with a second-generation tyrosine kinase inhibitor to an alternative TKI Ma CE et al. Leuk Res, December 2021
Overview of clinical and genetic features of CML patients with variant Philadelphia translocations involving chromosome 7: A case series Bayrak AG et al. Leuk Res, December 2021
Second-generation tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients with stable deep molecular response: A systematic review and meta-analysis Di Q et al. Comput Math Methods Med, December 2021 – open access publication
November 2021
Droplet digital PCR for BCR-ABL1 monitoring in diagnostic routine: Ready to start? Bochiccio MT et al. Cancers (Basel), Oct 2021 – open access publication	Tnfrsf4-expressing regulatory T cells promote escape of chronic myeloid leukemia stem cells Hinterbrandner M et al. JCI Insight, November 2021 (epub ahead of print) – open access publication
A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs Réa D et al. Blood, November 2021	Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR203/ABL1 and circ_0051886/miR-637/ABL1 Lu YH and Huang ZY. Mol Med, November 2021 – open access publication
The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis Shoukier M et al. Haematologica, November 2021 – open access publication	Activated naïve gammadelta T cells accelerate deep molecular response to BCR-ABL inhibitors in patients with chronic myeloid leukemia Chang YY et al. Blood Cancer J, November 2021 – open access publication
Asciminib for CML: same target, new arrow Schiffer CA Blood, November 2021	MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common ß chain cytokine receptor endocytosis Zhao H et al. Blood, November 2021 (epub ahead of print)
Taming the gatekeeper: ponatinib dose holds the key Branford S Blood, November 2021	Age- and gender-independent association of XRCC1 polymorphism with chronic myeloid leukemia Abdalhabib EK Int J Gen Med, November 2021 – open access publication
Analyzing the impact of pregnancy on the outcomes of childbearing age women with chronic myeloid leukemia Santos FM et al. Am J Hematol, November 2021 (epub ahead of print) – open access publication	Salidroside inhibits chronic myeloid leukemia cell proliferation and induces apoptosis by regulating the miR-140-5p/wnt5a/beta-catenin axis Chen D and Luo C. Exp Ther Med, November 2021 – open access publication
Statins enhance the molecular response in chronic myeloid leukemia when combined with tyrosine kinase inhibitors Jang HJ Cancers (Basel), November 2021 (epub ahead of print)	Accurate machine-learning-based classification of leukemia from blood smear images Dese K et al. Clin Lymphoma Myeloma Leuk, November 2021
Risk factors for outcome after allogeneic stem cell transplantation in patients with advanced phase CML Niederwieser C et al. Bone Marrow Transplant, November 2021 – open access publication	How to predict relapse in leukemia using time series data: A comparative in silicio study Hoffmann H et al. PLoSOne, November 2021 – open access publication
Asciminib as a new option in the treatment of chronic myeloid leukemia Ibis B ete al. Future Oncol, November 2021 (epub ahead of print)
Monitoring and improving adherence to tyrosine kinase inhibitors in patients with chronic myeloid leukemia: A systematic review Tan BK et al. Patient Prefer Adherence, November 2021 – open access publication
Safety and cost-effectiveness of ponatinib versus other tyrosine kinase inhibitors as second-line therapy in patients with chronic myeloid leukemia in the US Yue X et al. Leuk Lymphoma, November 2021 (epub ahead of print)
Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors Nakamae M et al. Int J Hematol, November 2021 (epub ahead of print)
A randomized, phase II trial of adjuvant immunotherapy with durable TKI-free survival in patients with chronic phase CML Webster JA et al. Leuk Res, November 2021 (epub ahead of print)
A narrative review on adverse effects of dasatinib with a focus on pharmacotherapy of dasatinib-induced pulmonary toxicities Nekoukar Z et al. Blood Res, November 2021 (epub ahead of print) - open access publication
October 2021
Droplet digital PCR for BCR-ABL1 monitoring in diagnostic routine: Ready to start? Bochiccio MT et al. Cancers (Basel), Oct 2021 – open access publication	Investigation on the interaction behaviour of afatinib, dasatinib, and imatinib docked to the BCR-ABL protein Rocha KML eta l. J Mol Mode, October 2021
Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors: a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT Masouridi-Levrat S et al. Bone Marrow Transplant, October 2021 (epub ahead of print) – open access publication	Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers Krishnan V et a. Haematologica, October 2021 (epub ahead of print) – open access publication
Making treatment-free remission (TFR) easier in chronic myeloid leukemia: Fact checking and practical management tools Castagnetti F et al. Target Oncol, October 2021 (epub ahead of print) - open access publication	Ultra-deep sequencing mutation analysis of the BCR/ABL1 kinase domain in newly diagnosed chronic myeloid leukemia patients Park H et al. Leuk Res, October 2021 (epub ahead of print)
Prediction of cardiovascular events in patients with chronic myeloid leukemia using baseline risk factors and coronary artery calcium scoring Baggio D et al. Intern Med J, October 2021	Small molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance Song T et al. Leukemia, October 2021
Imatinib plasma levels in patients with chronic myeloid leukemia under routine clinical practice conditions Del Rosario García B et al. J Oncol Pharm Pract, October 2021	JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signalling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia Aranda-Tavío H et al. Biomed Pharmacother, October 2021 (epub ahead of print)
Pharmacokinetics of asciminib when taken with imatinib or with food Hoch M et al. Clin Pharmacol Drug Dev, October 2021 (epub ahead of print)	3D tissue engineered plasma cultures support leukemic proliferation and induces drug-resistance Alhallah K et al. Leuk Lymphoma, October 2021
Treatment-free remission: the new goal in CML therapy Atallah E and Sweet K. Curr Hematol Malig Rep, October 2021 (epub ahead of print) – open access publication	Aberrantly reduced expression of miR-342-5p contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistance Wu YY et al. Cell Death Dis, October 2021 (open access publication)
The evolving landscape of frontline therapy in chronic phase chronic myeloid leukemia (CML) Wolfe HR and Rein LAM. Curr Hematol Malig Rep, October 2021 (epub ahead of print)
The cure of leukemia through the optimist’s prism Kantarjian HM et al. Cancer, October 2021 (epub ahead of print)
Novel BCR-ABL1 tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia Malik S et al. Expert Rev Hematol, October 2021 (epub ahead of print)
Health-related quality of life of patients with chronic myeloid leukemia as measured by patient-reported outcomes: Current state and future directions Schoenbeck KL and Flynn KE. Curr Hematol Malig Rep, October 2021 (epub ahead of print)
Nilotinib-induced bone marrow CD34+/lin-Ph+ cells early clearance in newly diagnosed CP-chronic myeloid leukemia: Final report of the PhilosoPhi34 Study Pungolino E et al. Eur J Hematol, October 2021 – open access publication
Serial evaluation of the pharmacokinetics of ponatinib in patients with CML and PH+ ALL Kawano N et al. Int J Hematol, October 2021
Which tyrosine kinase inhibitors should be selected as the first-line treatment for chronic myelogenous leukemia in chronic phase? Ono T. Cancers (Basel), October 2021 - open access publication
September 2021
Quality of life improvements in patients with chronic myeloid leukemia after stopping long-term therapy: who can benefit the most? Efficace F and Baccarani M. J Natl Cancer Inst, September 2021 (epub ahead of print) - open access publication	Genetic heterogeneity in chronic myeloid leukemia: How clonal hematopoiesis and clonal evolution may influence prognosis, treatment outcomes, and risk of cardiovascular events Sant’Antonio E et al. Clin Lymphoma Myeloma Leuk, September 2021
Patient-reported functional outcomes in patients with chronic myeloid leukemia after stopping tyrosine kinase inhibitors Schoenbeck KL et al. J Natl Cancer Inst, September 2021 (epub ahead of print)	Granulocyt and monocytic myeloid-derived suppressor cells are functionally and prognostically different in patients with chronic myeloid leukemia Ahn A et al. Ann Lab Med, September 2021 – open access publication
Chronic myeloid leukemia: Modern therapies, current challenges and future directions Osman AEG and Deininger MW. Blood Rev, September 2021	Association of creatine elevation with clinical outcomes in chronic myeloid leukemia: a retrospective cohort study Bankar A and Lipton LH. Leuk Lymphoma, September 2021 (epub ahead of print)
Long-term follow-up of frontline Dasatinib in older patients with chronic myeloid leukemia in chronic-phase treated outside clinical trials: a real-life cohort observational study Stagno F et al. Acta Oncol, September 2021 (epub ahead of print)	Intracellular delivery of anti-BCR-ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells Jiang G et al. J Hematol Oncol, September 2021 – open access publication
Second- or third-generation tyrosine kinase inhibitors in first-line treatment of chronic myeloid leukemia in general population: is there a real benefit? Canet J et al. Cancer Med, September 2021 (epub ahead of print) – open access publication	BCR-ABL1 transcript doubling time as a predictor for tre atment free remission after imatinib discontinuation in chronic myeloid leukemia Kim DDH et al. Br J Hematol, September 2021 (epub ahead of print)
Current evidence of the efficacy and safety of generic imatinib in CML and the impact of generics on health care costs Erçaliskan A et al. Blood Adv, September 2021 - open access publication	Spred1 deficit promotes treatment resistance and transformation of chronic phase CML Qiao J et al. Leukemia, September 2021 (epub ahead of print)
How I treat chronic phase chronic myelogenous leukemia Berman E et al. Blood, September 2021 (epub ahead of print)	Compromised anti-tumor-immune features of myeloid cell components in chronic myeloid leukemia patients Harada I et al. Sci Rep, September 2021 – open access publication
Chronic myeloid leukemia with pure erythroid leukemic blast crisis Jacobs JW et al. Leuk Lymphoma, September 2021 (epub ahead of print)	PKC-beta/Alox5 axis activation promotes BCR-ABL-independent TKI-resistance in chronic myeloid leukemia Ma D et al. J Cell Physiol, September 2021
Debating frontline therapy in chronic myeloid leukemia Bi X et al. Front Oncol, September 2021 – open access publication	Mitochondrial metabolism as a potential therapeutic target in myeloid leukemia de Breauchamp L et al. Leukemia, September 2021 (epub ahead of print) - open access publication
Nilotinib versus Imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: 10-year follow-up of the Japanese subgroups of the randomized ENESTnd trial Nakamae H et al. Int J Hematol, September 2021 (epub ahead of print)
Response to tyrosine kinase inhibitors in real-world patients with chronic myeloid leukemia Szeto AH et al. Ann Pharmacother, September 2021 (epub ahead of print) – open access publication
Severe pleural effusion associated with nilotinib for chronic myeloid leukemia: cross-intolerance with tyrosine kinase inhibitors Satoh K et al. BMJ Case Rep, September 2021
August 2021
A phase 3, open-label, randomized study of Asciminib, a STAMP inhibitor, vs Bosutininb in CML after ≥ prior TKI’s Rea D et al. Blood, August 2021 (epub ahead of print)	ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells Yang S et al. Blood, August 2021 (epub ahead of print)
Ponatinib dose-ranging study in chronic-phase chronic myeloid leukemia: A randomized, open-label phase 2 clinical trial Cortes J et al. Blood, August 2021 (epub ahead of print)	Detection of mutations in CML patients resistant to tyrosine kinase inhibitor: imatinib msylate therapy Karasu N et al. Med Oncol, August 2021
Chronic myeloid leukemia Cortes J et al. Lancet, August 2021 (epub ahead of print)	Does eventually NPM1 mutation in blast phase chronic myeloid leukemia (BP-CML) exist? That is the question. Henry A et al. Br J Haematol, August 2021 (epub ahead of print) – open access publication
Inotuzumab ozoganicin with bosutinib for relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia or lymphoid blast phase of chronic myeloid leukemia Jain N et al. Am J Hematol, August 2021	Molecular, cytogenetic, and haematological analysis of chronic myeloid leukemia patients and discovery of two novel translocations Asif M et al. Anal Cell Pathol (Amst), August 2021 – open access publication
Pulmonary hypertension in patients with chronic myeloid leukemia Song IC et al. Medicine (Baltimore), August 2021 – open access publication	CRISPR-Cas9 technology as a tool to target gene drivers in cancer: proof of concept and new opportunities to treat chronic myeloid leukemia Vuelta E et al. CRISPR J, August 2021
Bosutinib in the real-life treatment of chronic myeloid leukemia patients aged > 65 years resistant/intolerant to previous tyrosine-kinase inhibitors Latagliata R et al. Hematol Oncol, August 2021	Genomic copy number variants in CML patients with the Philadelphia chromosome (Ph+): An update Zhang H et al. Front Genet, August 2021 – open access publication
Extramedullary blast crisis in a chronic myeloid leukemia patient after achieving a major molecular response with bosutinib Nakajima R et al. Br J Haematol, August 2021 (epub ahead of print) – open access publication	From the archives of MD Anderson Cancer Center: Concurrent BCR-ABL1 and CRLF2 rearrangements in B-lymphoblast phase of chronic myeloid leukemia Thakral B et al. Ann Diagn Pathol, August 2021
Early prediction of stable MR(4.5) by depth of molecular response at 6 months in patients with chronic myeloid leukemia treated with frontline imatinib Nee A et al. Leuk Lymphoma, August 2021 (epub ahead of print)	KIR3DL1 allotype-dependent modulations of NK cell immunity against chronic myeloid leukemia Izumi K et al. Immunohorizons, August 2021
Asciminib: an investigational agent for the treatment of chronic myeloid leukemia Breccia et al. Expert Opion Investig Drugs, August 2021	MiR-150 expression in chronic myeloid leukemia: Relation to imatinib response Habib EM et al. Lab Med, August 2021 (epub ahead of print)
Is the Sokol or EUTOS long-term survival (ELTS) score a better predictor of responses and outcomes in persons with chronic myeloid leukemia receiving tyrosine-kinase inhibitors? Zhang XS et al. Leukemia, August 2021 (epub ahead of print) – open access publication	Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia Qing Y et al. Cell Commun Signal, August 2021 – open access publication
Tyrosine kinase inhibitor and vascular adverse events in chronic myeloid leukemia patients: a population-based, prospensity score-matched cohort study Chen MT et al. Oncologist, August 2021 (epub ahead of print) – open access publication
Long-term tolerability and efficacy after initial PegIFN- α addition to dasatinib in CML-CP – five year follow-up of the Nord CML007 study Flygt H et al. Eur J Haematol, August 2021 (epub ahead of print) – open access publication
Treatment free remission in patients with chronic myeloid leukemia: recommendations of LALNET expert panel Pavlovsky C et al. Blood Adv, August 2021 (epub ahead of print) - open access publication
Treatment-free remission in chronic myeloid leukemia: Can we identify prognostic factors? Scifullah HH and Lucas CM. Cancers (Basel), August 2021 – open access publication
July 2021
Dasatinib dose optimisation based on therapeutic drug monitoring reduces pleural effusion rates in chronic myeloid leukemia patients Rousselot P et al. Br J Haematol, July 2021	TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signalling Agarwal P et al. Cell Rep, July 2021 – open access publication
Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity Janssen L et al. Haematologica, July 2021 – open access publication	ND-09 inhibits chronic myeloid leukemia K562 cell growth by regulating BCR-ABL signalling Liu YH et al. Oncol Rep, July 2021 – open access publication
Ophthalmologic manifestations as the initial presentation of chronic myeloid leukemia: A Review Yassin MA et al. Surv Ophthalmol, July 2021 (epub ahead of print) – open access publication	Role of lysophospholipid metabolism in chronic myelogenous leukemia stem cells Naka K. Cancers(Basel), July 2021 – open access publication
Arterial hypertension assessment in a population with chronic myeloid leukemia Roa-Chamorro R et al. Sci Rep, July 2021 – open access publication	DNA methylation and intra-clonal heterogeneity: The chronic myeloid leukemia model Lebecque B et al. Cancers(Basel), July 2021 – open access publication
Thyroid autoimmunity and hypothyroidism are associated with deep molecular response in patients with chronic myeloid leukemia in tyrosine kinase inhibitors Rodia R et al. J Endocrinol Invest, July 2021 (epub ahead of print) – open access publication	HNRNPH1 is a novel regulator of cellular proliferation and disease progression in chronic myeloid leukemia Liu M et al. Front Oncol, July 2021 – open access publication
Efficacy and cardiovascular adverse events of long-term treatment with tyrosine kinase inhibitors for chronic myeloid leukemia: A Report from the Nagasaki CML Study Group Chiwata M et al. Intern Med, July 2021 – open access publication	Profiles of NK cell subsets are associated with successful tyrosine kinase inhibitor discontinuation and changes following interferon treatment Kong J et al. Ann Hematol, July 2021 (epub ahead of print)
Comparison of hepatotoxicity associated with new BCR-ABL tyrosine kinase inhibitors vs. imatinib among patients with chronic myeloid leukemia: A systematic review and meta-analysis Wang Z et al. JAMA Netw open, July 2021 – open access publication	Hierarchical distribution of somatic variants in newly diagnosed chronic myeloid leukemia at diagnosis and early follow-up Romzova M et al. Br J Haematol, July 2021 (epub ahead of print)
Impact of BCR-ABL1 transcript type on response, treatment-free remission rate and survival in chronic myeloid leukemia patients treated with imatinib Marcé S et al. J Clin Med, July 2021 – open access publication
Quality of life among chronic myeloid leukemia patients in the second line treatment with nilotinib and influential factors Nguyen CTT et al. Quali Life Res, July 2021 (epub ahead of print)
Correlates of fatigue severity in patients with chronic myeloid leukemia treated with targeted therapy Oswald LB et al. Support Care Cancer, July 2021 (epub ahead of print)
June 2021
Impact of frontline treatment approach on outcome of myeloid blast phase CML Saxena K et al. J Hematol Oncol, June 2021 – open access publication	Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia Shindo T et al. Immunol Med, June 2021
Long-term cardiac, vascular, hypertension, and effusion safety of bosutinib in patients with Philadelphia chromosome-positive leukemia resistant or intolerant to prior therapy Cortes J et al. Eur J Haematol, June 2021 – open access publication	Gata2-L359V impairs primitive and definitive hematopoiesis nd blocks cell differentiation in murine chronic myelogenous leukemia models Fu YK et al. Cell Death Dis, June 2021 – open access publication
Measuring prognosis in chronic myeloid leukemia: What’s new? Breccia M et al. Expert Rev Hematol, June 2021 (epub ahead of print)	Zfp36I1 plays an ambiguous role in the regulation of cell expansion and negatively regulates Cdkn1a in chronic myeloid leukemia cells Kaehler M et al. Exp Hematol, June 2021 (epub ahead of print)
Treatment-free remission of chronic myeloid leukemia in real-world practice by the detected limit of MR4.3 Park P et al. Leuk Res, June 2021	Cytochrome P4502C19 gene polymorphisms (CYP2C192 and CYP2C193) in chronic myeloid leukemia patients: in vitro and in silico studies Joshi K et al. J Biomol Struct Dyn, June 2021 (epub ahead of print)
Appropriate starting does of dasatinib based on analyses of dose-limiting toxicities and molecular responses in Asian patients with chronic myeloid leukemia Shin H et al. Clin Lymphoma Myeloma Leuk, June 2021	Multiplex technologies for the assessment of minimal residual disease and low-level mutation detection in leukemia: mass spectrometry versus next generation sequencing Shanmunagathan N and Branford S. Br J Haematol, June 2021 (epub ahead of print)
Asciminib: an investigational agent for the treatment of chronic myeloid leukemia Breccia M et al. Expert Opin Investig Drugs, June 2021 (epub ahead of print)	Metabolic alterations mediated by STAT3 promotes drug persistence in CML Patel SB et al. Leukemia, June 2021 (epub ahead of print) - open access publication
Subsequent attempt tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia; a single institute experience Ureshino H et al. Hematol Oncol, June 2021 (epub ahead of print)	CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells Kim JH et al. Biochem Pharmacol, June 2021 (epub ahead of print)
Successful tyrosine kinase inhibitor discontinuation outside clinical trials – data from the population-based Swedish CML Registry Flygt H et al. Br J Haematol, June 2021 – open access publication	Assessment of droplet digital polymerase chain reaction for measuring BCR-ABL1 in chronic myeloid leukemia in an International interlaboratory study Scott S et al. Br J Haematol, June 2021 (epub ahead of print) – open access publication
Pharmakokinetics of Asciminib in individuals with hepatic or renal impairment Hoch M et al. J Clin Pharmacol, June 2021 (epub ahead of print)	Positive interactions between STAP1 and BCR-ABL influences chronic myeloid leukemia cell proliferation and survival Ishiura M et al. Biochem Biophys Res Comm, June 2021
Perspectives and emotional experiences of patients with chronic myeloid leukemia during ENESTPath clinical trial and treatment-free remission: Rationale and protocol of the Italian substudy Borghi L et al. Front Oncol, May 2021 – open access publication	Targeting FEN1 suppresses the proliferation of chronic myeloid leukemia cells through regulating alternative end-joining pathways Zhu Y et al. DNA Cell Biol, June 2021 (epub ahead of print)
Review of new-generation tyrosine kinase inhibitors for chronic myeloid leukemia Shoukier M et al. Curr Oncol Rep, June 2021	Brefeldin A induces apoptosis, inhibits BCR-ABL activation, and triggers BCR-ABL degradation in CML K562 cells Zhang JM et al. Anticancer Agents Med Chem, June 2021 (epub ahead of print)
Nilotinib induced bone marrow CD34+/lin-Ph+ cells early clearance in newly diagnosed CP-chronic myeloid leukemia: final report of the PhilosoPhi34 study Pungolino E et al. Eur J Haematol, June 2021 (epub ahead of print)	Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells Liu Z et al. Exp Cell Res, June 2021 (epub ahead of print)
May 2021
Long-term treatment-free remission in patients with chronic myeloid leukemia after second-line nilotinib. ENESTop 5-year update Hughes TP et al. Leukemia, May 2021 (epub ahead of print)	Target spectrum of the BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemic Lee H et al. Int J Hematol, May 2021
Why chronic myeloid leukemia cannot be cured by tyrosine kinase inhibitors Baccarani M and Gale RP. Leukemia, May 2021 (epub ahead of print)	Suppression of USP1 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis Jiang S et al. Cell Death Dis, May 2021 – open access publication
EUTOS long-term survival score discriminated different SOKAL score categories in chronic myeloid leukemia patients, showing better survival prediction. Analysis of the GIMEMA CML observational study Breccia M et al. Leukemia, May 2021 (epub ahead of print)	Mutational landscape of chronic myeloid leukemia: more than a single oncogene Adnan-Awad S et al. Leuk Lymphoma, May 2021 (epub ahead of print)
Budget impact of tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia with sustained deep molecular response Astruge C et al. Value Health, May 2021	Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review Torres-Barrera P et al. Curr Res Transl Med, May 2021 (epub ahead of print)
Relevance of treatment-free remission recommendations in chronic phase chronic myeloid leukemia patients treated with frontline tyrosine kinase inhibitors Etienne G et al. Cancer Med, May 2021 (epub ahead of print) – open access publication	Validation of CIP2A as a biomarker of subsequent disease progression and treatment failure in chronic myeloid leukemia Clark RE et al. Cancers(Basel), May 2021 – open access publication
Evaluation of two CE-IVD tests for BCR-ABL1 transcript monitoring of chronic myeloid leukemia patients Folta A et al. Leuk Lymphoma, May 2021	Clonal evolution and clinical implications of genetic abnormalities in blastic transformation in chronic myeloid leukemia Ochi Y et al. Nat Commun, May 2021 – open access publication
Promyelocytic blast phase of chronic myeloid leukemia; BCR-ABL1 positive: Points to be considered at diagnosis Kim B et al. Ann Lab Med, May 2021 – open access publication	Sirtuin1 and chronic myeloid leukemia: A comprehensive glance of drug resistance Abbasian S et al. Clin Lab, May 2021
Adverse events among chronic myelogenous leukemia patients treated with tyrosine kinase inhibitors: A real-world analysis of health plan enrolees Chow EJ et al. Leuk Lymphoma, May 2021
An indirect comparison between bosutinib, nilotinib and dasatinib in chronic phase chronic myeloid leukemia Muresan B et al. Curr Med Res Opin, May 2021 (epub ahead of print)
Overcoming TKI resistance in a patient with chronic myeloid leukemia using combination BCR-ABL inhibition with asciminib and bosutinib Hall KH et al. Am J Hematol, May 2021 (epub ahead of print) – open access publication
Current status and novel strategy for CML Morita K and Sasaki K. Int J Hematol, May 2021
April 2021
Asciminib in chronic myeloid leukemia: Many questions still remain to be answered Eskazan AE. Blood Cancer J, April 2021 – open access publication	Recent advances in understanding chronic myeloid leukemia: Where do we stand? Kumar R and Krause DS. Fac Rev, April 2021 – open access publication
Outcome of patients with chronic myeloid leukemia in lymphoid blastic phase and Philadelphia chromosome-positive acute lymphoblastic leukemia treated with hyper-CVAD and dasatinib Morita K et al. Cancer, April 2021 (epub ahead of print)	Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape Hsieh YC et al. Leukemia, April 2021 (epub ahead of print) – open access publication
Survival of chronic myeloid leukemia patients in comparison to the general population in the tyrosine kinase inhibitors era: A US population based study Jamy O et al. Am J Hematol, April 2021 (epub ahead of print) - open access publication	Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy Schoepf AM et al. Eur J Med Chem, April 2021 – open access publication
Optimal duration of imatinib treatment/deep molecular response for treatment-free remission after imatinib discontinuation from a Canadian tyrosine kinase inhibitor discontinuation trial Kim DDH et al. Br J Haematol, April 2021 (epub ahead of print)	An aging mouse model of human chronic myeloid leukemia Hao T et al. Oncogene, April 2021 (epub ahead of print)
Efficacy and safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the Asian subpopulation of the phase 3 BFORE trial Chuah C et al. Int J Hematol, April 2021 (epub ahead of print)	Repositioning antispasmodic drug papaverine for the treatment of chronic myeloid leukemia Parcha PK et al. Pharmacol Rep, April 2021
Bosutinib-related pleural effusion in patients with chronic myeloid leukemia Yüzbasloglu MB and Eskazan AE. Expert Opin Drug Saf, April 2021	The regulation of bcr-abl in hypoxia is through the mTOR pathway Clapper E et al. Leuk Lymphoma, April 2021
Real-life evaluation of potential candidates for treatment discontinuation in chronic myeloid leukemia: the impact of age and long-term follow-up Scalzulli E et al. Leuk Lymphoma, April 2021	Leukemic stem cells shall be searched in the bone marrow before tyrosine kinase inhibitor-discontinuation in chronic myeloid leukemia Ilhan O et al. Int J Lab Hematol, April 2021 (epub ahead of print)
When to stop TKIs in patients with chronic myeloid leukemia and how to follow them subsequently Cerveira N et al. Curr Treat Options Oncol, April 2021	Rare monosomy 7 and deletion 7p at diagnosis of chronic myeloid leukemia in accelerated phase Alswied A et al. Cancer Genet, April 2021
Interventions to improve adherence to tyrosine kinase inhibitors in chronic myeloid leukemia: A systematic review Heiney SP et al. Am J Clin Oncol, April 2021 (epub ahead of print)
March 2021
Dosing strategies for improving the risk-benefit profile of ponatinib in patients with chronic myeloid leukemia in chronic phase Castagnetti F et al. Front Oncol, March 2021 – open access publication	Targeting chronic myeloid leukemia stem/progenitor cells using Venetoclax-loaded immunoliposome Houshmand M et al Cancers(Basel), March 2021 – open access publication
Third-line therapy for chronic myeloid leukemia: Current status and future directions Cortes J and Lang F. J Hematol Oncol, March 2021 – open access publication	Smoothened inhibitor erismodegib combined with nilotinib in patients with chronic myeloid leukemia resistant/intolerant to at least one prior tyrosine kinase inhibitor: a phase 1b study Ottmann OG et al. Leuk Lymphoma, March 2021
Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial Radich JP et al. Leukemia, March 2021 (epub ahead of print) – open access publication	Treatment-free remission and immunity in chronic myeloid leukemia Ureshino H. Int J Hematol, March 2021 (epub ahead of print)
Asessment of individual molecular response in chronic myeloid leukemia patients with atypical BCR-ABL1 fusion transcripts: recommendations by the EUTOS cooperative network Schäfer V et al. J Cancer Res Clin Oncol, March 2021 (epub ahead of print) – open access publication	New routes to eradicating chronic myelogenous leukemia stem cells by targeting metabolism Naka K. Int J Hematol, March 2021 (epub ahead of print)
Tyrosine kinase inhibitor therapy discontinuation in patients with chronic myeloid leukemia in chronic phase in the United States after clinical practice guideline updates Atallah EL et al. Leuk Lymphoma, March 2021 (epub ahead of print)	Efficiency of nilotinib to target chronic-phase chronic myeloid leukaemia primary mature CD34- and immature CD34+ cells Berger MG et al. Sci Rep, March 2021 – open access publication
The safety and efficacy of dasatinib plus nivolumab in patients with previously treated chronic myeloid leukemia: results from a phase 1b dose-escalation study Martínez-López J et al. Leuk Lymphoma, March 2021 (epub ahead of print)	The discovery of novel BCR-ABL tyrosine kinase inhibitors using a pharmacophore modelling and virtual screening approach Huang TT et al. Front Cell Dev Biol, March 2021 – open access publication
I rock the boat? When to stop TKI’s in CML? Nazha A. Blood, March 2021	Discovery of a novel CIP2A variant (NOCIVA) with clinical relevance in predicting TKI resistance in myeloid leukemias Makela E et al. Clin Cancer Res, March 2021 (epub ahead of print) – open access publication
Long-term follow-up of late chronic phase chronic myeloid leukemia patients treated with imatinib after interferon failure: a single center experience Pepe S et al. Leuk Lymphoma, March 2021 (epub ahead of print)	Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), play an oncogeneic role in chronic myeloid leukemia by stabilizing nuclear factor-kappa B Bencome-Alvarez AE, Oncogene, March 2021 (epub ahead of print) – open access publication
Ponatinib long-term follow-up of efficacy and safety in CP-CML patients in real world setting in France: The POST-PACE study Etienne G et al. Leuk Res, March 2021 (epub ahead of print)	Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of CML progression Sloma I et al. Haematologica, March 2021 – open access publication
Real-life comparison of nilotinib versus dasatinib as second-line therapy in chronic phase chronic myeloid leukemia patients Scalzulli E et al. Ann Hematol, March 2021 (epub ahead of print)
arly BCR-ABL kinetics are predictive of subsequent achievement of treatment-free-remission in CML Shanmunagathan N et al. Blood, March 2021
February 2021
Molecular response and quality of life in chronic myeloid leukemia patients treated with intermittent TKI’s: First interim analysis of OPTkIMA study Malagola M et al. Cancer Med, February 2021 (epub ahead of print) - open access publication	Additional chromosomal abnormalities at chronic myeloid leukemia diagnosis predict an increased risk of progression Clark RE et al. Blood Adv, February 2021 - open access publication
Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR – final report from AFTER-SKI Richter J et al. Leukemia, February 2021 (epub ahead of print) – open access publication	Eradicating residual chronic myeloid leukemia: basic research lost in translation Zhao H and Deininger M. Lancet Haematol, February 2021
Mortality rates in patients with chronic myeloid leukemia in chronic phase with frontline second generation kinase inhibitors: a retrospective analysis by the monitoring registries of the Italian Medicines Agency (AIFA) Breccia M et al. Ann Hematol, February 2021	Exosomes released by imatinib-resistant K562 cells contain specific membrane markers, IFTM3, CD146 and CD36 and increase the survival of imatinib-sensitive cells in the presence of imatinib Hrdinova T et al. Int J Oncol, February 2021
Dose-optimization of tyrosine kinase inhibitors in chronic myeloid leukemia: A new therapeutic challenge Iurlo A et al. J Clin Med, February 2021 – open access publication	Assessment of azithromycin as an anticancer agent for treatment of imatinib sensitive and resistant CML cells Ozkan T et al. Leuk Res, February 2021 (epub ahead of print)
Bosutinib in the real-life treatment of chronic myeloid leukemia patients >65 years resistant/intolerant to previous tyrosine-kinase inhibitors Latagliata R et al. Hematol Oncol, February 2021 (epub ahead of print)	Circulating miR-1461 expression to imatinib in adult chronic myeloid leukemia Habib EM et al. J Investig Med, February 2021
Safety and efficacy of asciminib treatment in chronic myeloid leukemia patients in real-life clinical practice Garcia-Gutiérrez V et al. Blood Cancer J, February 2021 – open access publication	Future approaches for treating chronic myeloid leukemia: CRISP therapy Vuelta E et al. Biology(Basel), February 2021 – open access publication
MR4 log and low levels of NK cells are associated with higher molecular relapse after imatinib discontinuation: Results of a prospective trial Seguro FS et al. Leuk Res, February 2021	Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells Yahata T et al. Haematologica, February 2021 – open access publication
Optimizing health-related quality of life in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors Efficace F et al. Expert Rev Hematol, February 2021 (epub ahead of print)	Co-existence of BCR-ABL and JAK2V617F mutation in resistant chronic myeloid leukemia in the imatinib era: is there a correlation? Frikha R et al. J Oncol Pharm Pract, February 2021 (epub ahead of print)
ong-term cardiac, vascular, hypertension, and effusion safety of bosutinib in patients with Philadelphia chromosome-positive leukemia resistant or intolerant to prior therapy Cortes JE et al. Eur J Haematol, February 2021 (epub ahead of print)	The prognostic importance of BCR-ABL transcripts in chronic myeloid leukemia: A systematic review and meta-analysis Ghalesardi OK et al. Leuk Res, February 2021
	Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML) Lu T et al. Eur J Pharmacol, February 2021 (epub ahead of print)
January 2021
Clinical outcomes of patients with chronic myeloid leukemia with concurrent core binding factor rearrangement and Philadelphia chromosome Morita K et al. Clin Lymphoma Myeloma Leuk, January 2021 (epub ahead of print)	The giant HECT E3 ubiquitin ligase HERC1 is aberrantly expressed in myeloid related disorders and it is a novel BCR-ABL1 binding partner Ali MS et al. Cancers(Basel), January 2021 – open access publication
Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed CML in chronic phase: ENESTnd 10-year analysis Kantarjian HM et al. Leukemia, January 2021 (epub ahead of print) – open access publication	Genetic screening for potential new targets in chronic myeloid leukemia based on Drosophia Transgenic for human BCR-ABL Lo Iacono M et al. Cancers(Basel), January 2021 – open access publication
I Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukemia: results from the French SPIRIT phase III randomised trial Guilhot F et al. Leukemia, January 2021 (epub ehead of print)	The quiescent fraction of chronic myeloid leukemia stem cells depends on BMPR1B, STAT3, and BMP4-niche signals to persistent in patients in remission Jeanpierre S et al. Haematologica, January 2021 – open access publication
Digital droplet PCR as a predictive tool for successful discontinuation outcome in chronic myeloid leukemia: Is it time to introduce it in the clinical practice? Colafigli G et al. Crit Rev Oncol Hematol, January 2021	HLA polymorphis are associated with treatment-free re mission following discontinuation of TKI’s in CML Ureshino H et al. Mol Cancer Ther, January 2021
Low-density lipoprotein (LDL) levels and risk of arterial occlusive events in chronic myeloid leukemia in patients treated with nilotinib Caocci G et al. Ann Hematol, January 2021 (epub ahead of print)	Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTor pathway in combination with TKIs: A review Singh P et al. Med Oncol, January 2021
Treatment patterns and clinical outcomes of tyrosine kinase inhibitors in chronic-phase CML in clinical practice: 3-year European SIMPLICITY data Gambarcoti-Passerini C et al. Eur J Haematol, January 2021 – open access publication	The BCRP inhibitor febuxostat enhances the effect of nilotinib by regulation of intracellular concentration Ito F et al. Int J Hematol, January 2021
Adherence, persistence and efficacy of dasatinib and nilotinib in the treatment of patients resistant or intolerant to imatinib with chronic myeloid leukemia in chronic phase: an Italian multicenter study over two years in real-life Santoleri F et al. Curr Med Res Opin, January 2021 (epub ahead of print)	NT157, an IGF1R-IRS1/2 inhibitor exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia Scopim-Ribeiro R et al. Invest New Drugs, January 2021 (epub ahead of print)
Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukemia in the United Kingdom: the UK TARGET CML study Milojkociv D et al. Br J Haematol, January 2021 – open access publication
BCR-ABL kinase domain mutation analysis by Next Generation Sequencing detected additional mutations in CML patients with suboptimal response to Nilotinib Benjamin ESB et al. Leuk Lymphoma, January 2021 (epub ehead of print)

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Publications on COVID-19 and CML/Cancer - 2021

December 2021

Durable humoral responses after the second anti-SARS-CoV-2 vaccine dose in chronic leukemia patients on tyrosine kinase inhibitors
Claudiani S et al. Br J Haematol, December 2021 (epub ahead of print) – open access publication
Safety of SARS-CoV-2 vaccines in patients with chronic myeloid leukemia: a multicentre survey in China
Yang et al. Clin Med J (Engl), December 2021 (epub ahead of print) – open access publication
Outcome of COVID-19 in patients with CML: A single centre UK experience
Nesr G et al. J Med Virol, December 2021 (epub ahead of print)
Serum antibody response in patients with Philadelphia-chromosome positive or negative myeloproliferative neoplasms following vaccination with SARS-CoV-2 spike protein messenger RNA (mRNA) vaccines
Kozak KE et al. Leukemia, December 2021 – open access publication
Evaluation of COVID-10 vaccine response in patients with cancer: An interim analysis
Tran S et al. Eur J Cancer, December 2021 – open access publication
Immune response following third COVID-19 vaccination are reduced in patients with haematological malignancies compared to patients with solid cancer
Fendler A et al. Cancer Cell, December 2021 (epub ahead of print) – open access publication
Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with haematological malignancies
Tamariz-Amador LE. Blood Cancer J, December 2021 – open access publication
Low rate of seroconversion after mRNA anti-SARS-CoV-2 vaccination in patients with haematological malignancies
Re D et al. Leuk Lymphoma, December 2021
Systematic screening for SARS-CoV-2 in patients with haematological malignancies on active anticancer treatment in the outpatient setting
Varettoni M et al. Leuk Lymphoma, December 2021
Efficacy and safety of heterologous booster vaccination with Ad26Cov2.S after BNT162b2 mRNA COVID-19 vaccine in haemato-oncological patients with no antibody response
Reimann P et al. Br J Haematol, December 2021 (epub ahead of print) – open access publication
Antibody response after vaccination against SARS-CoV-2 in adults with haematological malignancies: a systematic review and meta-analysis
Gagelmann N et al. Haematologica, December 2021 (epub ahead of print) – open access publication

November 2021

Is COVID-19 less severe in CML patients than in those with other haematological cancers?
Claudiani S. Br J Haematol, October 2021 (epub ahead of print) – open access publication
Serological SARS-CoV-2 antibody response, potential predictive markers and safety of BNT162b2 mRNA COVID-19 vaccine in haematological and oncological patients
Benda M et al. B J Haematol, November 2021 – open access publication
COVID-19 in vaccinated adult patients with haematological malignancies: preliminary results from EPICOVIDEHA
Pagano L et al. Blood, November 2021 (epub ahead of print)

October 2021

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A campus CML report
Breccia M et al. Br J Haematol, October 2021 (epub ahead of print) - open access publication
COVID-19 infection in adult patient with haematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)
Pagano L et al. J Hematol Oncol, October 2021 – open access publication
Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials. Lessons from the CounterCOVID-imatinib study
Bartelink IH et al. CPT Pharmacometics Syst Pharmacol, October 2021
(epub ahead of print) – open access publication
COVID-19 and seasonal influenza: a comparative analysis in patients with haematological malignancies
Modemann F et al. Leuk Lymphoma, October 2021 (epub ahead of print)
BNT162b2 COVID-19 vaccine is significantly less effective in patients with haematological malignancies
Herzog-Tzarfati K et al. Am J Hematol, October 2021 – open access publication
COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality: a Polish National study
Weclawek-Tampol J et al. J Hematol Oncol, October 2021 – open access publication

September 2021

The serological prevalence of SARS-CoV-2 infection in patients with chronic myeloid leukemia is similar to that in the general population
Bonifacio M et al. Cancer Med, September 2021 – open access publication
Clinical profile and outcomes of COVID-19 in haematological malignancies: experience from tertiary care centre in India
Gupta A et al. Ann Hematol, September 2021 (epub ahead of print)
Clinical characteristics and outcomes of patients with haematological malignancies and COVI-19 suggest that prolonged SARS-CoV-2 carriage is an important issue
Arcani R et al. Ann Hematol, September 2021 (epub ahead of print) – open access publication
Implementation of a hospital-at-home (HAH) unit for haematological patients during the COVID-19 pandemic: safety and feasibility
Gómez-Centurión I et al. Int J Hematol, September 2021 (epub ahead of print) – open access publication

August 2021

The care of the leukemic patients in times of SARS-CoV-2
Karki NK et al. Curr Oncol Rep, August 2021 – open access publication
A novel system for semiautomatic sample processing in chronic myeloid leukemia: Increasing throughput without impacting on molecular monitoring at time of SARS-CoV-2 pandemic
Stella S et al. Diagnostics (Basel), August 2021 – open access publication
COVID-19 among patients with haematological malignancies: A national Israeli retrospective analysis with special emphasis on treatment and outcome
Levy I et al. Leuk Lymphoma, August 2021 (epub ahead of print)
Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies
Malard F et al. Blood Cancer J, August 2021 – open access publication
Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies
Greenberger LM et al. Cancer Cell, August 2021 – open access publication
Multiple cranial nerve palsies revealing blast crisis in patient with chronic myeloid leukemia in the accelerated phase under nilotinib during severe infection with SARS-CoV-19 virus: Case report and review of literature
Bouchlarhem A et al. Radiol Case Rep, August 2021 (epub ahead of print) – open access publication
Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study
Mukkada S et al. Lancet Oncol, August 2021 (epub ahead of print)
Seroconversion and kinetic of anti SARS-CoV-2 antibodies in 25 patients with haematological malignancies who recovered from SARS-CoV-2 infection
Candoni A et al. Hematol Oncol, August 2021 – open access publication

July 2021

COVID-19 in chronic myeloid leukemia patients in Latin America
Pagnano KB et al. Leuk Lymphoma, July 2021 (epub ahead of print)
Preclinical evaluation of imatinib does not support its use as an antiviral drug against SARS-CoV-2
Touret F et al. Antiviral Res, July 2021 (epub ahead of print) – open access publication
COVID-19 elicits an impaired antibody response against SARS-CoV-2 in patients with haematological malignancies
Passamonti F et al. Br J Haematol, July 2021 (epub ahead of print) – open access publication

June 2021

Single dose BNT162b1 mRNA vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces neutralising antibody and polyfunctional T-cell responses in patients with CML
Harrington P et al. Br J Haematol, June 2021 (epub ahead of print)
– open access publication
Mental health in persons with chronic myeloid leukemia during the SARS-CoV-2 pandemic: The need for increased access to healthcare services
Bao M et al. Front Psychiatry, June 2021 – open access publication
The impact of COVID-19 on patients with haematological malignancies: the mixed-method analysis of an Israeli National survey
Levy I et al. Support Care Cancer, June 2021 (epub ahead of print) – open access publication
COVID-19 and stem cell transplantation; results from an EBMT and GETH multicentre prospective survey
Ljungman P et al. Leukemia, June 2021 (epub ahead of print) – open access publication
Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and cancer Consortium
Grivas P et al. Ann Oncol, June 2021 – open access publication
Epidemiological and clinical characteristics of cancer patients with COVID-19: A systematic review and meta-analysis of global data
Kong X et al. Cancer Lett, June 2021 – open access publication

May 2021

Impact of COVID-19 on cancer care in India: A cohort study
Ranganathan P et al. Lancet Oncol, May 2021 (epub ahead of print) - open access publication
When hematologic malignancies meet COVID-19 in the United State: Infections, death and disparities
Wang Q et al. Blood Rev, May 2021
COVID-19 among children with cancer in Greece (2020). Results from the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumours (NARECHEM-ST)
Baka M et al. Pediatr Blood Cancer, May 2021 (epub ahead of print) - open access publication
COVID-19 vaccines for patients with haematological conditions
Sun C et al. Lancet Hematol, May 2021 – open access publication
Mortality in hospitalized patients with cancer and coronavirus disease 2019: A systematic review and meta-analysis of cohort studies
Desai A et al. Cancer, May 2021 – open access publication
Comparison and impact of COVID-19 for patients with cancer: a survival analysis of fatality rate for age, sex and cancer type
Li H et al. BMJ Health Care Inform, May 2021 – open access publication

April 2021

Clinical characteristics and risk factors for mortality in cancer patients with COVID-19
Liang J et al. Front Med, April 2021 – open access publication
2021 update of the AGIHO Guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnosis, viral shredding, vaccination and therapy
Giesen N et al. Eur J Cancer, April 2021 – open access publication
Consequences of the COVID-19 pandemic on cancer clinical trials
Flores S et al. Cancer Med J, April 2021 – open access publication
Impact of cancer history on outcomes among hospitalized COVID-19 patients
Klein IA et al. Oncologist, April 2021 – open access publication
COVID-19 and cancer – 1 year on
The Lancet Oncology, April 2021 – open access publication

March 2021

Early administration of convalescent plasma improves survival in patients with haematological malignancies and COVID-19
Biernat MM et al. Viruses, March 2021 – open access publication
Risk stratification and outreach to hematology/oncology patients during the COVID-19 pandemic
Osterman CK et al. Support Care Cancer, March 2021 – open access publication
COVID-19 in chronic-phase chronic myeloid leukemia patients: A single-center survey from Turkey
Yilmaz U et al. Turk J Haematol, February 2021 – open access publication
Blurring of vision as the only symptom of undiagnosed case of chronic myeloid leukemia in the COVID-19 era
Gumaste P and Vairagyam R. Indian J Ophthalmol, March 2021 – open access publication
Mild clinical course of COVID-19 infection in chronic myeloid leukemia (CML) patients receiving tyrosine kinase inhibitors (TKI’s) without interruption
Demeter J et al. Mediterr J Hematol Infect Dis, March 2021 – open access publication
COVID-19 in patients with haematological malignancies: Considering the role of tyrosine kinase inhibitors
Morale-Ortega A et al. Cancer, March 2021 (epub ahead of print) – open access publication
Reply to COVID-19 in patients with haematological malignancies: Considering the role of tyrosine kinase inhibitors
Cattaneo C et al. Cancer, March 2021 (epub ahead of print) – open access publication
Clinical presentations and outcomes of children with cancer and COVID-19: A systematic review
Prasad Meena J et al. Pediatr Blood Cancer, March 2021 (epub ahead of print) – open access publication
Challenges and opportunities for COVID-19 vaccines in patients with cancer
Kuderer NM et al. Cancer Invest, March 2021

February 2021

Kinase inhibitors developed for treatment of hematologic malignancies: implications for immune modulation in COVID-19
Jacobs CF et al. Blood Adv, February 2021 - open access publication
ASH registry offers insights on COVID-19 in patients with haematological malignancies
Oncologist, February 2021 – open access publication
Reduction in the rate and improvement in the prognosis of COVID-19 in haematological patients over time
Cattaneo C et al. Leukemia, February 2021 – open access publication
Priority COVID-19 vaccination for patients with cancer while vaccine supply is limited
Ribas A et al. Cancer Discov, February 2021
Cancer patients and COVID-19: Mortality, serious complications, biomarkers, and ways forward
Gupta K et al. Cancer Treat Res Commun 2021 - open access publication

January 2021

COVID-19 induced Pancytopenia in a major molecular response CML patient on dasatinib: A case report and review of the literature
Singh B et al. Eur J Case Rep Intern Med, January 2021 – open access publication
Lymphopenia as a biological predictor of outcomes in COVID-19 patients: A Nationwide Cohort Study
Lee J et al. Cancers(Basel), January 2021 – open access publication

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Jorge Cortes (Augusta, USA)
Brian Druker (Portland, USA)
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Michael Mauro (New York, USA)
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Clinical Publications	Scientific Publications
December 2020
TKI dose reduction can effectively maintain major mol ecular remission in patients with chronic myeloid leukemia Claudiani S et al. Br J Haematol, December 2020 (epub ahead of print)	Identification of immunological parameters as predictive biomarkers of relapse in patients with chronic myeloid leukemia on treatment-free remission Vigón L et al. J Clin Med, December 2020 – open access publication
Discontinuation of tyrosine kinase inhibitors in chronic myel oid leukemia: When and for whom? Atallah E and Schiffer CA. Haematologica, December 2020 – open access publication	Targeting of the Alox12-12-HETE in blast crisis chronic myeloid leukemia inhibits leukemia stem/progenitor cell function (Gao S et al. Cancer Manag Res, December 2020) – open access publication
Why is it critical to achieve a deep molecular remission in chronic myeloid leukemia? Branford S. Haematologica, December 2020 – open access publication	Inhibitors targeting STAT5 signaling in myeloid leukemias: New Tetrahydroquinoline derivates with improved antileukemic potential (Prié G et al. ChemMedChem, December 2020)
BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analysed by NGS (Soverini S et al. Leukemia, December 2020) (epub ahead of print)	Let-7b regulates the Adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells (Zhou X etc. Leuk Lymphoma, December 2020)
First-generation vs second-generation tyrosine kinase inhibitors: which is best at diagnosis of chronic-phase chronic myeloid leukemia (Oehler VG. Hematology Am Soc Hematol Educ Program, December 2020) – open access publication	Evidence that knock down of GSK-3beta in chronic myelogenous leukemia cells augments IFN-gamma-induced apoptosis (Kauffmann MR et al. Leuk Res, December 2020)
Tyrosine kinase inhibitor discontinuation in the management of chronic myeloid leukemia: a critical review of the current practice (Breccia M et al. Expert Rev Hematol, December 2020)	Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis (Tanabe Y et al. Blood Adv, December 2020) – open access publication
Efficacy and safety of pioglitazone in a phase 1/2 imatinib discontinuation trial (EDI-PIO) in chronic myeloid leukemia with deep molecular response (Pagnano KBB et al. Am J Hematol, December 2020) – open access publication	Novel strategies to eradicate resistant cells in chronic myeloid leukemia (Schopf AM and Gust R. Future Med Chem, December 2020)
Management of chronic myeloid leukemia during pregnancy among patients with tyrosine kinase inhibitor: a single-Centre experience (Assi R et al. Leuk Lymphoma, December 2020) (epub ahead of print)	Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients (Schmitz U et al. Cancers (Basel), December 2020) – open access publication
Quality of life and symptom burden with first- and second generation tyrosine kinase inhibitors in patients with chronic-phase chronic myeloid leukemia (Boston H et al. Clin Lymphoma Myeloma Leuk, December 2020)	Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation (Wang N et al. Exp Ther Med, December 2020) – open access publication
Switch from branded to generic imatinib: impact on molecular responses and safety in chronic-phase chronic myeloid leukemia patients (Scalzulli E et al. Ann Hematol, December 2020)
Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for CML: A systematic review (Szakács Z et al. PLoS One, December 2020) – open access publication
Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era (Liu Z et al. Hematology, December 2020)
November 2020
How to manage CML patients with comorbidities (Cortes J. Blood, November 2020) – open access publication	Characterization of p190 BCR-ABL chronic myeloid leukemia reveals specific signalling pathways and therapeutic targets (Adnan-Awad S et al. Leukemia, November 2020) (epub ahead of print)
Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia (Abaza Y et al. Am J Hematol, November 2020)	P19^INK4dinhibits proliferation and enhances imatinib efficacy through BCR-ABL signalling pathway in CML (Kuang Y et al. Blood Cells Mol Dis, November 2020)
Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: Updates from the LAST study on patient-reported outcomes and biomarkers for relapse (Braun TP and Druker BJ. JAMA Oncol, November 2020)	AMD1 is required for the maintenance of leukemia stem cells and promotes chronic myeloid leukemic growth (Sari IN et al. Oncogene, November 2020) (epub ahead of print)
The LEukemia Artificial Intelligence Program (LEAP) in chronic myeloid leukemia in chronic phase: A model to improve patient outcomes (Sasaki K et al. Am J Hematol, November 2020) (epub ahead of print)	The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase (Manley PW et al. Leuk Res, November 2020)
Assessment of outcomes after stopping tyrosine kinase inhibitors among patients with chronic myeloid leukemia: A nonrandomized clinical trial (Atallah E et al. JAMA Oncol, November 2020) (epub ahead of print)
Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: update form the LAST study on patient-reported outcomes and biomarkers for relapse (Braun TP and Druker BJ. JAMA Oncol, November 2020) (epub ahead of print)
Handling challenging questions in the management of chronic myeloid leukemia: When is it safe to stop tyrosine kinase inhibitors? (Rea D. Blood Adv, November 2020) – open access publication
Increased tumor burden in patients with CML after 36 months of imatinib discontinuation (Diral E et al. Blood, November 2020)
There is a best duration of deep molecular response for treatment-free remission, but it is patient-specific, and that is the challenge (Ross DM and Hughes TP. Br J Haematol, November 2020) (epub ahead of print)
Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia (Efficace F et al. Leuk Lymphoma, November 2020) (epub ahead of print)
Predictors of tyrosine kinase inhibitor adherence trajectories in patients with newly diagnosed chronic myeloid leukemia (Clark SE et al. J Oncol Pharm Pract, November 2020) (epub ahead of print)
Standardization of BCR-ABL1 p210 monitoring: From nested to digital PCR (Jovanovski A et al. Cancers (Basel), November 2020) – open access publication
Point: Is there a best duration of deep molecular response to achieve therapy-free remission in chronic myeloid leukemia? (Gale RP and Saglio G. Br J Haematol, November 2020) (epub ahead of print)
A retrospective analysis about frequency of monitoring in Italian chronic myeloid leukemia patients after discontinuation (Dragani M et al. J Clin Med, November 2020) – open access publication
Tyrosine kinase inhibitor treatment discontinuation in CML: patient views (Tromp VNMF et al. Leuk Lymphoma, November 2020) (epub ahead of print) – open access publication
October 2020
Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: opinion, evidence and recommendations (Abruzzese E et al. Ther Adv Hematol, October 2020) - open access publication	Recent advances in BCR-ABL tyrosine kinase inhibitors for overriding T315I mutation (Liu J et al. Chem Biol Drug Des, October 2020) (epub ahead of print)
Comparison of droplet digital PCR versus qPCR measurements on the International Scale for the molecular monitoring of chronic myeloid leukemia patients (Cortés AA et al. Mol Diagn Thera, October 2020)	Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem cell and progenitor cells in AML and CML (Herrmann H et al. Blood Adv October 2020) – open access publication
The EUTOS long-term survival score predicts disease-specific mortality and molecular responses among patients with CML in a practice-based cohort (Sato E et al. Cancer Med, October 2020) (epub ahead of print) - open access publication	Increased expression of TIGIT/CD57 in peripheral blood/bone marrow NK cells in patients with chronic myeloid leukemia (Yao D et al. Biomed Res Int, October 2020) – open access publication
Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when and for whom? (Atallah E and Schiffer C A. Haematologica, October 2020 ) – open access publication	AMP-activated protein kinase activation primes cytoplasmic translocation and authophagic degradation of the BCR-ABL protein in CML cells (Koyama D et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication
Chronic myeloid leukemia, Version 2.2021, NCCN Clinical Practice Guidelines (Deininger MW et al. J Natl. Compr Canc Netw, October 20 20) – open access publication	In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, October 2020) – open access publication
Chronic myeloid leukemia in solid organ transplant patients: a case series (Amitai I et al. Int J Hematol, October 2020) (epub ahead of print)	PD-1 expressing CD56-negative NK cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment (Ishiyama KI et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication
Treatment outcomes in chronic myeloid leukemia: Does one size fit all? (Garcia-Horton A and Lipton JH. J Natl Compr Canc Netw, October 2020) – open access publication	CytoGPS: A large-scale karyotype analysis of CML data (Abrams ZB et al. Cancer Genet, Octo ber 2020) (epub ahead of print)
Favourable outcome of chronic myeloid leukemia co-expressing e13a2 and e14a2 transcripts, treated with nilotinib (Mulas O et al. Hematol Oncol, October 2020)	Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signalling complex (Gregor T et al. Cell Mol Sci, October 2020)
On the road to treatment-free remission in chronic myeloid leukemia: What about ‘the others’? (Stagno F et al. Expert Rev Anticancer Ther, October 2020) (epub ahead of print)	DYRK2 controls a key regulatory network in chronic myeloid leukemia (Park CS and Lacorazza HD. Exp Mol Med, October 2020) (epub ahead of print) - open access publication
Case series of chronic myeloid leukemia patients who maintained deep molecular response (DMR) with very low-dose ponatinib: experience in discontinuing low-dose ponatinib and treatment-free remission (TFR) outcomes (Cohen J et al. Leuk Lymphoma, October 2020)	Detection of residual disease in CML utilizing genome next generation sequencing reveals persistence of differentiated Ph(+) B cells but not bone marrow/stem progenitors (Karigane D et al. Leuk Lymphoma, October 2020) (epub head of print)
Dasatinib treatment long-term results among imatinib-resistant/intolerant patients with chronic phase chronic myeloid leukemia are favourable in daily clinical practice (Zackova D et al. Leuk Lymphoma, October 2020) (epub ahead of print)	Examination of clinically-derived p210 BCR/ABL1 RhoGEF mutations in a murine model marrow transplantation of CML (Ciccarelli BT et al. Leuk Res, October 2020)
September 2020
Why is it critical to achieve a deep molecular response in chronic myeloid leukemia? (Branford S. Haematologica, September 20 20) – open access publication	CML – Not only BCR-ABL1 matters (Rinke J et al. Best Pract Res Clin Haematol, September 2020)
Breakpoints mapping of a t(9;22;12) chronic myeloid leukemia patient with e14a3 BCR-ABL1 transcript using nanopore sequencing (Zhao H et al. J Gene Med, September 2020) (epub ahead of print)	Declaration of BCR-ABL1 independence (Zhao H and Deininger MW. Leukemia, September 2020)
Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia (Shanmunagathan N et al. Blood, September 2020) (epub ahead of print)	Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells (Tanaka Y et al. Exp Hematol, September 2020)
Incidence of deep molecular responses and treatment-free remission in de novo CP-CMO patients (Etienne G et al. Cancers(Basel), September 2020) – open access publication	Checkpoint kinase-1 inhibitors and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologenous recombination DNA damage repair (Fan Z et al. Oncol Rep, September 2020) (epub ahead of print) - open access publication
Erythropoietin treatment in chronic myeloid leukemia patients treated with frontline imatinib who developed anaemia (Cesini L et al. Eur J Hematol, September 2020)	A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor chronic myeloid leukemia cells (He B et al. Biomed Pharmacother, September 2020) – open access publication
Treatment-free remission in chronic myeloid leukemia harbouring atypical BCR-ABL1 transcripts (Dragani M et al. Mediterr J Hematol Infect Dis, September 2020) – open access publication	BCR-ABL allosteric inhibitors: Where we are and where we are going to (Carofiglio F et al. Molecules, September 2020) – open access publication
Unravelling surviving expression in chronic myeloid leukemia: Molecular interactions and clinical implications (Bernardo PS et al. Blood Rev, September 2020)
Second-line dasatinib therapy improved compliance and deep molecular responses in imatinib-intolerant chronic myeloid leukemia patients (Markovic U et al. Anticancer Res, September 2020)
Impact of the BCR-ABL1 transcript type on clinical and biological parameters and molecular response in patients with chronic myeloid leukemia (Nachi M et al. Hematol Oncol Stem Cell Ther, September 2020) – open access publication
Response and adherence to nilotinib in daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotonib (Boons CCLM et al. Eur J Pharmacol, September 2020) – open access publication
August 2020
Moving on from 2013 to 2020 European LeukemiaNet recommendations for treating chronic myeloid leukemia: what has changed over the 7 years? (Yilmaz U & Eskazan AE. Expert Rev Hematol, August 2020) (epub ahead of print) - open access publication	SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem cell disorders (Kaiser A et al. Leukemia, August 2020
A phase 1 study to evaluate the feasibility and efficacy of the addition of ropeginterferon alpha-2b to imatinib in patients with chronic phase chronic myeloid leukemia (CML) not achieving a deep molecular response (molecular remission 4.5) – AGMT-CML1 (Heibl S et al. Hematol Oncol, August 2020) (epub ahead of print)	RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses (Adnan Awad S et al. Leukemia, August 2020) (epub ahead of print) – open access publication
Treatment-free remission in chronic myeloid leukemia: the patient perspective and areas of unmet needs (Sharf G et al. Leukemia, August 2020) – open access publication	Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML (Toda J et al. Oncogene, August 2020) – open access publication
Low-dose tyrosine kinase inhibitors before treatment discontinuation do not repair treatment-free remission in chronic myeloid leukemia patients: Results of a retrospective study (Cayassials E et al. Cancer, August 2020) – open access publication	A high-content cytokine screen identifies myostatin propeptides as a positive regulator of primitive chronic myeloid leukemia cells (von Palffy S et al. Haematologica, August 2020) – open access publication
Epidural myeloid sarcoma a the presenting symptom of chronic myeloid leukemia blast crisis (Slouma M et al. Clin Rheumatol, August 2020) – open access publication	Nuclear receptors as potential therapeutic targets for myeloid leukemia (Pan P & Chen X. Cells, August 2020)
Ponatinib therapy in recurrent Philadelphia chromosome-positive central nervous system leukemia with T315I mutation after Allo-HSCT (He JB et l. Int J Cancer, August 2020) – open access publication	In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, August 2020) (epub ahead of print) – open access publication
Vascular events may predict the prognosis of patients with chronic myeloid leukemia (Ureshino H & Kamachi K. Int J Hematol, August 2020) – open access publication	Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia (Greiner L et al. Int J Cancer, August 2020) – open access publication
Effect of age and comorbidities on the decline of glomerular filtration rate in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors (Lucijanic M & Krecak I. Int J Hematol, August 2020) – open access publication	Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis (Liu J et al. Oncol Lett, August 2020) – open access publication
Use of generic imatinib as first-line treatment in patients with chronic myeloid leukemia (CML): the GIMS (Glivec to Imatinib Switch) study) (Genelli M et al. Blood Res, August 2020) (epub ahead of print) – open access publication	Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis (Liu J et al. Oncol Lett, August 2020) – open access publication
	Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo (Jyotsana N et al. Ann Hematol, August 2020) – open access publication
July 2020
A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukemia (Smith G et al. Br J Haematol, July 2020) (epub ahead of print) – open access publication	PVR and ICAM-1 on blast crisis CML stem and progenitor cells with TKI resistance confer susceptibility to NK cells (Kim N et al. Cancers (Basel), July 2020)
Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia (Abecasis M et al. Leukemia, July 2020) – open access publication	Tyrosine kinase inhibitors induce alternative spliced BCR-ABL (Ins35bp) variant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, July 2020) – open access publication
Current treatment options for chronic myeloid leukemia patients failing second-generation tyrosine kinase inhibitors (García-Gutiérrez V & Hernández-Boluda JCC. J Clin Med, July 2020) – open access publication	Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors (Rothe K et al. Cell Stem Cells, July 2020) (epub ahead of print)
Surrogate markers for treatment-free remission in patients with chronic myeloid leukemia (Ureshino H et al. Clin Lymphoma Myeloma Leuk, July 2020) (epub ahead of print) - open access publication	Therapeutic inhibition of FcγRIIb signaling targets leukemia stem cells in chronic myeloid leukemia (Parting O et al. Leukemia, July 2020) (epub ahead of print) - open access publication
Comparison of BCR-ABL1 quantification in pheripheral blood and bone marrow using an International scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, July 2020) – open access publication	Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells (Hallal R et al. J Cell Mol Med, July 2020) (epub ahead of print) – open access publication
Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia (Abaza Y et al. Am J Hematol, July 2020) (epub ahead of print)	Targeting SKP2/BCR-ABL pathway with Diosmetin suppresses chronic myeloid leukemia proliferation (Liu Y et al. Eur J Pharmacol, July 2020) (epub ahead of print)
Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity (Janssen L et al. Haematologica, July 2020)
Late molecular recurrences in patients with chronic myeloid leukemia experiencing treatment-free remission (Rousselot P et al. Blood Adv, July 2020) – open access publication
Another set of guidelines for chronic myeloid leukaemia (Clark RE. Br J Haematol, July 2020) (epub ahead of print)
Evidence of BCR-ABL1-positive progenitor spread in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML) (Turhan AG et al. Leuk Lymphoma, July 2020)
Platelet function in patients with chronic myeloid leukemia treated with asciminib (Nesr G et al. Leuk Lymphoma, July 2020) (epub ahead of print)
Timing for allogeneic hematopoietic cell transplantation (alloHCT) for chronic myeloid leukemia (CML) patients (Hu B et al. Leuk Lymphoma, July 2020) (epub ahead of print)
June 2020
The EUTOS long-term survival (ELTS) score is superior to the Sokol score for predicting survival in chronic myeloid leukemia (Pfirrmann M et al. Leukemia, June 2020) (epub ahead of print) - open access publication	An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TK et al. Blood, June 2020) (epub ahead of print)
First-line imatinib vs second- and third-generation TKI’s for chronic phase CML: a systematic review and data analysis (Vener C et al. Blood Adv, June 2020) – open access publication	Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression (Sloma I et al. Haematologica, June 2020) (epub ahead of print) - open access publication
Influence of major BCR-ABL1 transcript subtype on outcomes in patients with chronic myeloid leukemia in chronic phase treated frontline with nilotinib (Gentham A et al. Oncotarget, June 2020) – open access publication	The HDAC6 inhibitor 7b induces BCR-ABL ubiquitation and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia (Losson H et al. Pharmacol Res, June 2020) (epub ahead of print)
Current strategies and future directions to achieve deep molecular response and treatment-free remission in chronic myeloid leukemia (Annunziata M et al. Front Oncol, June 2020) – open access publication	Micro RNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2 mediated autophagy (Li YL et al. Hum Cell, July 2020)
Chronic myeloid leukemia prognosis and therapy: Criticisms and perspectives (Russo D et al. J Clin Med, June 2020) – open access publication	Inhibition of USP1, a new partner of BCR-ABL, results in decrease of BCR-ABL level in K562 cells (Antonenko SV et al. Exp Oncol June 2020)
Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study (Hochhaus A et al. Leukemia, June 2020) (epub ahead of print) - open access publication	Blastic transformation of BCR-ABL1 positive chronic myeloid leukemia through acquisition of CBFB-MYH11 and mutant KIT (Shoumariyeh K et al. B J Haematol, June 2020) (epub ahead of print) -open access publication
How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis from the monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, June 2020) – open access publication
Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia (Pagani IS et al. Leuk Lymphoma, June 2020) (epub ahead of print)
The clinical impact of time to response in de Novo accelerated-phase chronic myeloid leukemia (Ohanian M et al. Am J Hematol, June 2020) (epub ahead of print)
May 2020
Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors (Hochhaus A et al. Leukemia, May 2020) (epub ahead of print) - open access publication	Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis (Tang Z et al. Mod Pathol, May 2020) (epub ahead of print)
High-risk additional chromosomal abnormalities at low blast counts herald death by CML (Hehlmann R et al. Leukemia, May 2020) (epub ahead of print) – open access publication	Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: Recent advances (Cumbo C et al. Cancer Manag Res, May 2020) – open access publication
Analysis of chronic myeloid leukemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission (Machova Polakova K et al. Leukemia, May 2020) (epub ahead of print)	Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication
Delayed resistance to imatinib after 16 years of therapy in a patient with chronic myeloid leukemia (Kaur U et al. Br J Haematol, May 2020) (epub ahead of print) - open access publication	Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells (Lernoux M et al. Clin Epigenetics, May 2020) – open access publication
Prolonged treatment-free remission in chronic myeloid leukemia patients with previous BCR-ABL1 kinase domain mutations (Claudiadini S et al. Haematologica, May 2020) (epub ahead of print) - open access publication	ERBB₂/HER₂mutations are transforming and therapeutically targetable in leukemia (Joshi SK. Leukemia, May 2020) (epub ahead of print) - open access publication
Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the last ten years (Dulucq S et al. Br J Haematol, May 2020) – open access publication	Coexistance of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in CML: A case report (Shi XB et al. World J Clin Cases, May 2020) – open access publication
Treatment-free remission in patients with chronic myeloid leukemia (Ross DM and Hughes TP. Nat Rev Clin Oncol, May 2020) (epub ahead of print)	Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia (Yu C et al. Haematologica, May 2020) – open access publication
Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis (Wang Q et al. Leuk Lymphoma, May 2020)	Recruiting TP53 to target chronic myeloid leukemia stem cells Grant S. Haematologica, May 2020 – open access publication http://www.haematologica.org/content/105/5/1172
	ABL genomic editing sufficiently abolished oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo (Chen SH et al. Cancers (Basel), May 2020) – open access publication
	Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (Ma CC et al. J Int Med Res, May 2020) – open access publication
	High-risk additional chromosomal abnormalities at low blast counts herald death by CML (Hehlmann R et al. Leukemia, May 2020) (epub ahead of print) - open access publication
	Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication
	Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia (Kumar R et al. Leukemia, May 2020) (epub ahead of print) - open access publication
	Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis (Xiao FY et al. Life Sci, May 2020) – open access publication
	Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (MA CC et al. J Int Med Res, May 2020) – open access publication
April 2020
Response and resistance to BCR-ABL1-targeted therapies (Braun TP et al. Cancer Cell, April 2020)	Nobiletin promotes megakaryocytic differentiation through the MAPK/ERK-dependent EGR1 expression and exerts anti-leukemic effects in human chronic myeloid leukemia (CML) K562 cells (Yen JH et al. Cells, April 2020) – open access publication
Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased killer cells (Irani YD et al. Br J Haemaol, April 2020) (epub ahead of print) – open access publication	Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR-ABL/AKT/mTOR pathway (Zhang Z et al. Int J Mol Med, April 2020)
Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia (Brümmendorf TH et al. Ann Hematol, April 2020) (epub ahead of print) - open access publication	Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia (Gong Z et al. Br J Haematol, April 2020) (epub ahead of print) - open access publication
Venetoclax and BCR-ABL tyrosine kinase inhibitor combinations: outcome in patients with Philadelphia chromosome-positive advanced myeloid leukemias (Maiti A et al. Acta Haematol, April 2020) (epub ahead of print)	The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemia stem cells in CML (Lin H et al. Blood, April 2020) (epub ahead of print)
Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study (Cortes JE et al. Leukemia, April 2020) (epub ahead of print) – open access publication	Response and resistance to BCR-ABL-1 targeted therapies (Braun TP et al. Cancer Cell, April 2020)
Metabolic analysis of patients with chronic myeloid leukemia and cardiovascular adverse events after treatment with tyrosine kinase inhibitors (Caocci et al. J Clin Med, April 2020) – open access publication	GZD824 as a FLT3, FGFR1 and PDGFR-alpha inhibitor against leukemia in vitro and in vivo (Wang Y et al. Transl Oncol, April 2020) (epub ahead of print) - open access publication
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring (Jabbour E and Kantarjian H. Am J Hematol, April 2020) (epub ahead of print)	Basic knowledge on BCR-ABL1-positive extracellular vesicles (Jurj A et al. Biomark Med, April 2020) (epub ahead of print)
Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic-phase chronic myeloid leukemia based on early achievement of deep molecular response (MR^4.5): The phase 2, multicenter N-Road study (Nishiwaki K et al. Cancer Med, April 2020) (epub ahead of print) - open access publication	Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients (Spiess D et al. Ann Hematol, April 2020) (epub ahead of print) – open access publication
The differentiated diagnosis of basophilia in patients undergoing BCR-ABL testing (Smith CJ et al. Am J Hematol, April 2020) (epub ahead of print) - open access publication	A novel chimeric antigen receptor redirecting T-cell specificity towards CCD26+ cancer cells (Zhou S et al. Leukemia, April 2020) (epub ahead of print)
Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia (Hino M et al. Int J Hematol, April 2020) (epub ahead of print)	TKIs induce alternative spliced BCR-ABL^Ins35bpvariant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, April 2020) (epub ahead of print) - open access publication
How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis frontline monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, April 2020) (epub ahead of print) - open access publication	Induction of CML-specific immune response through cross-presentation triggered by CTP-mediated BCR-ABL-derived peptides (Yang H et al. Cancer Lett, April 2020) (epub ahead of print)
	Synthesis and characterization of Telmisartan-derived cell death modulators to circumvent imatinib resistance in chronic myeloid leukemia (Gust R et al. ChemMedChem, April 2020) (epub ahead of print) - open access publication
	Role of DNA damage response in suppressing malignant progression of chronic myeloid leukemia and Polycythemia Vera: Impact of different oncogenes (Stetka J et al. Cancers (Basel), April 2020) – open access publication
March 2020
TARGET: a survey of real-world management of chronic myeloid leukemia across 33 countries (Turkina A et al. Br J Haematol, March 2020) (epub ahead of publication)	Correction of Bcl-x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse model (Zhang J et al. Br J Haematol, March 2020) (epub ahead of print)
Risk stratification of chronic myeloid leukemia according to different prognostic scores (Aijaz J et al. Cureus, March 2020) – open access publication	An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TH et al. Blood, March 2020) (epub ahead of print)
Patient-initiated discontinuation of tyrosine kinase inhibitor for chronic myeloid leukemia (Langabeer SE et al. Case Rep Hematol, March 2020) – open access publication	Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and –resistant chronic myeloid leukemia cells (Jiang L et al. Eur J Pharmacol, March 2020) (epub ahead of print) – open access publication
European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia (Hochhaus A et al. Leukemia, March 2020) (epub ahead of print) – open access publication	Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells (Shibata N et al. Oncogene, March 2020) (epub ahead of print)
Pharmacokinetics of dasatinib in hemodialysis patient with chronic myeloid leukemia and chronic kidney disease (Mori J et al. Int J Hematol, March 2019) (epub ahead of print)	SIRT7: an influence factor in healthy aging and the development of age-dependet myeloid stem cell disorders (Kaiser A et al. Leukemia, March 2020) (epub ahead of print)
Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1^st-line tyrosine kinase inhibitor in Japan: the results of the new TARGET study 2^nd line (Sakurai M et al. Int J Hematol, March 2020) (epub ahead of print)	Ponatinib induces vascular toxicity through the Notch-1 signaling pathway (Madonna R et al. J Clin Med, March 2020) – open access publication
The multi-tyrosine kinase inhibitor ponatinib for chronic myeloid leukemia: Real-world data (Luciano L et al. Eur J Haematol, March 2020) (epub ahead of print)- open access publication	Involvement of MCL-1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315l(+) Ph+leukemia cells (Inoue C et al. Biochem Biophys Res Commun, March 2020) (epub ahead of print)
Novel therapeutic approaches in chronic myeloid leukemia (Özgür Y et al. Leuk, February 2020) (epub ahead of print)
Experience of living with chronic myeloid leukemia and adhering to tyrosine kinase inhibitors: A thematic synthesis of qualitative studies (Hewison A et al. Eur J Oncol Nurs, February 2020) – open access publication
BCR-ABL1 transcript decline ratio combined BCR-ABL1^IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia (Cai Z et al. J Cancer, February 2020) – open access publication
Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia (Eskazan AE. Leukemia, March 2020) (epub ahead of print)
Does patient sex play a role in treatment-free remission in chronic myeoid leukemia? (Ureshino H et al. Int J Hematol, March 2020) (epub ahead of print)
Significance of lymphocyte count, monocyte count, and lymphocyte-to-monocyte ratio in predicting molecular response in patients with chronic myeloid leukemia: A single center experience (Pepedil-Tanrikulu F et al. Clin Lab, March 2020)
Influence of proton pump inhibitors and H2-receptor antagonists on the efficacy and safety of dasatinib in chronic myeloid leukemia patients (Koutake Y et al. Int J Hematol, March 2020) (epub ahead of print)
February 2020
Side-effect profile and outcomes of ponatinib in the treatment of chronic myeloid leukemia (Chan O et al. Blood Adv, February 2020) – open access publication	Phosphorylation-dependent differences in CXCR4-LASP-AKT1 interaction between breast cancer and chronic myeloid leukemia (Butt E et al. Cells, February 2020) – open access publication
Prospects of achieving treatment-free remission in chronic myeloid leukemia) (Saglio G et al. Br J Haematol, February 2020) (epub ahead of print) - open access publication	Aberrant RAG-mediated recombination contributes in lymphoid blast crisis of chronic myeloid leukemia (Thomson DW et al. Leukemia, February 2020) (epub ahead of print)
Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the past ten years (Dulucq S et al. Br J Hematol, February 2020) (epub ahead of print)	Model-based inference and classification of immunological control mechanism from TKI cessation and dose reduction in CML patients (Hähnel T et al. Cancer Res, February 2020) (epub ahead of print)
Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results analysis (Wang Q et al. Leuk Lymphoma, January 2020) (epub ahead of print)	Comparison of BCR-ABL 1 quantification in peripheral blood and bone marrow using an international scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, February 2020) (epub ahead of print)
Mechanisms of cardiovascular toxicity of BCR-ABL 1 tyrosine kinase inhibitors in chronic myelogenous leukemia (Gustafson D et al. Curr Hematol Rep, February 2020) (epub ahead of print)	Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia (Huang W et al. Leukemia, February 2020) (epub ahead of print) - open access publication
A single center evaluation of cost savings related to treatment-free remission in chronic myeloid leukemia patients: the prerequisites of a pharmaco-economy larger study (Etienne G et al. Br J Haematol, February 2020) (epub ahead of print)	SRSF1 mediates cytokine induced impaired imatinib sensitivity in chronic myeloid leukemia (Sinnakannu JK et al. Leukemia, February 2020) (epub ahead of print)
Novel illumine-based next generation sequencing approach with one-round amplification provides early and reliable detection of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia (Romzova M et al. Br J Hematol, February 2020) (epub ahead of print)	Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia (Adnan Awad S et al. Blood Adv, February 2020) – open access publication
What’s NEXT for CML-NGS mutation screening? (Shanmunagathan N et al. Blood, February 2020)	The landscape of BCR-ABL mutations in patients with Philadelphia chromosome-positive leukaemias in the era of second-generation tyrosine kinase inhibitors (Chien SH et al. Hematol Oncol, February 2020) (epub ahead of print)
	DNA damage and DNA damage response in chronic myeloid leukemia (Popp HD et al. Int J Mol Sci, February 2020) – open access publication
	Nanomaterials as magic bullets in the treatment of leukemia (Houshmand M et al. Nanomaterials (Basel), February 2020) – open access publication
January 2020
Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia (Masarova L et al. Cancer, January 2020) (epub ahead of print)	The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin SCT/TAL-1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication
Long-term results of frontline dasatinib in chronic myeloid leukemia (Maiti A et al. Cancer, January 2020) (epub ahead of print)	How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study (Zhang H et al. J Biomol Strat Dyn January 2020)
Molecular dynamics during reduction of TKI dose reliably identify molecular recurrence after treatment cessation of CML (Gottschalk A et al. Blood, January 2020) (epub ahead of print)	Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukemia patients stopping tyrosine kinase inhibitor therapy (Söderlund S et al. Leuk Res, January 2020) (epub ahead of print)
A randomized phase II trial of hydroxychloroquine and imatinib alone for patients with chronic myeloid leukemia in major cytogenetic response with residual disease (Horne GA et al. Leukemia, January 2020) (epub ahead of print)	The leukemia stem cell: similarities, differences and clinical prospects in CML and AML (Vetrie D et al. Nat Rev Cancer, January 2020) (epub ahead of print)
Treatment patterns and deep molecular response in chronic-phase – chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study (Cortes J et al. Leuk Lymphoma, January 2020)	CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy (Kinstrie R et al. Leukemia, January 2020) (epub ahead of print)
What are the considerations for tyrosine kinase inhibitor discontinuation in chronic phase chronic myeloid leukemia? (Harrington P et al. Expert Rev Hematol, January 2020) (epub ahead of print)	Knock-out of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance (Herrmann AD et al. J Cell Mol Med, January 2020) (epub ahead of print) – open access publication
Successful planned pregnancy through vitrified-warmed embryo transfer in a women with chronic myeloid leukemia: Case report and literature review (Furukawa Y et al. Mediterr J Hematol Infect Dis, January 2020) – open access publication	Defining the niche interactions to target chronic myeloid leukemia stem cells (Mitchell R et al. Haematologica, January 2020) – open access publication
Treatment-free remission after first-line dasatinib treatment in patients with chronic myeloid leukemia in the chronic phase: the D-NewS study of the Kanto CL Study Group (Yamaguchi H et al. Int J Hematol, January 2020) (epub ahead of print)	The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin – SCL/TAL1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication
	Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells (Grandjenette C et al. Cancer Lett, January 2020)

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