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CML Publications 2020
CML Publications 2020
| Clinical Publications | Scientific Publications |
| December 2020 | |
| TKI dose reduction can effectively maintain major molecular remission in patients with chronic myeloid leukemia Claudiani S et al. Br J Haematol, December 2020 (epub ahead of print) |
Identification of immunological parameters as predictive biomarkers of relapse in patients with chronic myeloid leukemia on treatment-free remission Vigón L et al. J Clin Med, December 2020 – open access publication |
| Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: When and for whom? Atallah E and Schiffer CA. Haematologica, December 2020 – open access publication |
Targeting of the Alox12-12-HETE in blast crisis chronic myeloid leukemia inhibits leukemia stem/progenitor cell function (Gao S et al. Cancer Manag Res, December 2020) – open access publication |
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Why is it critical to achieve a deep molecular remission in chronic myeloid leukemia? |
Inhibitors targeting STAT5 signaling in myeloid leukemias: New Tetrahydroquinoline derivates with improved antileukemic potential (Prié G et al. ChemMedChem, December 2020) |
| BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analysed by NGS (Soverini S et al. Leukemia, December 2020) (epub ahead of print) |
Let-7b regulates the Adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells (Zhou X etc. Leuk Lymphoma, December 2020) |
| First-generation vs second-generation tyrosine kinase inhibitors: which is best at diagnosis of chronic-phase chronic myeloid leukemia (Oehler VG. Hematology Am Soc Hematol Educ Program, December 2020) – open access publication |
Evidence that knock down of GSK-3beta in chronic myelogenous leukemia cells augments IFN-gamma-induced apoptosis (Kauffmann MR et al. Leuk Res, December 2020) |
| Tyrosine kinase inhibitor discontinuation in the management of chronic myeloid leukemia: a critical review of the current practice (Breccia M et al. Expert Rev Hematol, December 2020) |
Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis (Tanabe Y et al. Blood Adv, December 2020) – open access publication |
| Efficacy and safety of pioglitazone in a phase 1/2 imatinib discontinuation trial (EDI-PIO) in chronic myeloid leukemia with deep molecular response (Pagnano KBB et al. Am J Hematol, December 2020) – open access publication |
Novel strategies to eradicate resistant cells in chronic myeloid leukemia |
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Management of chronic myeloid leukemia during pregnancy among patients with tyrosine kinase inhibitor: |
Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients (Schmitz U et al. Cancers (Basel), December 2020) – open access publication |
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Quality of life and symptom burden with first- and second generation tyrosine kinase inhibitors in patients with chronic-phase chronic myeloid leukemia |
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation (Wang N et al. Exp Ther Med, December 2020) – open access publication |
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Switch from branded to generic imatinib: impact on molecular responses and safety in chronic-phase chronic myeloid leukemia patients |
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Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for CML: |
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Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era |
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| November 2020 | |
| How to manage CML patients with comorbidities (Cortes J. Blood, November 2020) – open access publication |
Characterization of p190 BCR-ABL chronic myeloid leukemia reveals specific signalling pathways and therapeutic targets (Adnan-Awad S et al. Leukemia, November 2020) (epub ahead of print) |
| Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia (Abaza Y et al. Am J Hematol, November 2020) |
P19INK4d inhibits proliferation and enhances imatinib efficacy through BCR-ABL signalling pathway in CML (Kuang Y et al. Blood Cells Mol Dis, November 2020) |
| Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: Updates from the LAST study on patient-reported outcomes and biomarkers for relapse (Braun TP and Druker BJ. JAMA Oncol, November 2020) |
AMD1 is required for the maintenance of leukemia stem cells and promotes chronic myeloid leukemic growth (Sari IN et al. Oncogene, November 2020) (epub ahead of print) |
| The LEukemia Artificial Intelligence Program (LEAP) in chronic myeloid leukemia in chronic phase: A model to improve patient outcomes (Sasaki K et al. Am J Hematol, November 2020) (epub ahead of print) |
The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase (Manley PW et al. Leuk Res, November 2020) |
| Assessment of outcomes after stopping tyrosine kinase inhibitors among patients with chronic myeloid leukemia: A nonrandomized clinical trial (Atallah E et al. JAMA Oncol, November 2020) (epub ahead of print) |
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| Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: update form the LAST study on patient-reported outcomes and biomarkers for relapse (Braun TP and Druker BJ. JAMA Oncol, November 2020) (epub ahead of print) |
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| Handling challenging questions in the management of chronic myeloid leukemia: When is it safe to stop tyrosine kinase inhibitors? (Rea D. Blood Adv, November 2020) – open access publication |
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| Increased tumor burden in patients with CML after 36 months of imatinib discontinuation (Diral E et al. Blood, November 2020) |
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| There is a best duration of deep molecular response for treatment-free remission, but it is patient-specific, and that is the challenge (Ross DM and Hughes TP. Br J Haematol, November 2020) (epub ahead of print) |
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| Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia (Efficace F et al. Leuk Lymphoma, November 2020) (epub ahead of print) |
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| Predictors of tyrosine kinase inhibitor adherence trajectories in patients with newly diagnosed chronic myeloid leukemia (Clark SE et al. J Oncol Pharm Pract, November 2020) (epub ahead of print) |
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Standardization of BCR-ABL1 p210 monitoring: From nested to digital PCR |
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| Point: Is there a best duration of deep molecular response to achieve therapy-free remission in chronic myeloid leukemia? (Gale RP and Saglio G. Br J Haematol, November 2020) (epub ahead of print) |
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| A retrospective analysis about frequency of monitoring in Italian chronic myeloid leukemia patients after discontinuation (Dragani M et al. J Clin Med, November 2020) – open access publication |
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| Tyrosine kinase inhibitor treatment discontinuation in CML: patient views (Tromp VNMF et al. Leuk Lymphoma, November 2020) (epub ahead of print) – open access publication |
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| October 2020 | |
| Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: opinion, evidence and recommendations (Abruzzese E et al. Ther Adv Hematol, October 2020) - open access publication |
Recent advances in BCR-ABL tyrosine kinase inhibitors for overriding T315I mutation (Liu J et al. Chem Biol Drug Des, October 2020) (epub ahead of print) |
| Comparison of droplet digital PCR versus qPCR measurements on the International Scale for the molecular monitoring of chronic myeloid leukemia patients (Cortés AA et al. Mol Diagn Thera, October 2020) |
Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem cell and progenitor cells in AML and CML (Herrmann H et al. Blood Adv October 2020) – open access publication |
| The EUTOS long-term survival score predicts disease-specific mortality and molecular responses among patients with CML in a practice-based cohort (Sato E et al. Cancer Med, October 2020) (epub ahead of print) - open access publication |
Increased expression of TIGIT/CD57 in peripheral blood/bone marrow NK cells in patients with chronic myeloid leukemia (Yao D et al. Biomed Res Int, October 2020) – open access publication |
| Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when and for whom? (Atallah E and Schiffer CA. Haematologica, October 2020) – open access publication |
AMP-activated protein kinase activation primes cytoplasmic translocation and authophagic degradation of the BCR-ABL protein in CML cells (Koyama D et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication |
| Chronic myeloid leukemia, Version 2.2021, NCCN Clinical Practice Guidelines (Deininger MW et al. J Natl. Compr Canc Netw, October 2020) – open access publication |
In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, October 2020) – open access publication |
| Chronic myeloid leukemia in solid organ transplant patients: a case series (Amitai I et al. Int J Hematol, October 2020) (epub ahead of print) |
PD-1 expressing CD56-negative NK cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment (Ishiyama KI et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication |
| Treatment outcomes in chronic myeloid leukemia: Does one size fit all? (Garcia-Horton A and Lipton JH. J Natl Compr Canc Netw, October 2020) – open access publication |
CytoGPS: A large-scale karyotype analysis of CML data (Abrams ZB et al. Cancer Genet, October 2020) (epub ahead of print) |
| Favourable outcome of chronic myeloid leukemia co-expressing e13a2 and e14a2 transcripts, treated with nilotinib (Mulas O et al. Hematol Oncol, October 2020) |
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signalling complex (Gregor T et al. Cell Mol Sci, October 2020) |
| On the road to treatment-free remission in chronic myeloid leukemia: What about ‘the others’? (Stagno F et al. Expert Rev Anticancer Ther, October 2020) (epub ahead of print) |
DYRK2 controls a key regulatory network in chronic myeloid leukemia (Park CS and Lacorazza HD. Exp Mol Med, October 2020) (epub ahead of print) - open access publication |
| Case series of chronic myeloid leukemia patients who maintained deep molecular response (DMR) with very low-dose ponatinib: experience in discontinuing low-dose ponatinib and treatment-free remission (TFR) outcomes (Cohen J et al. Leuk Lymphoma, October 2020) |
Detection of residual disease in CML utilizing genome next generation sequencing reveals persistence of differentiated Ph(+) B cells but not bone marrow/stem progenitors (Karigane D et al. Leuk Lymphoma, October 2020) (epub head of print) |
| Dasatinib treatment long-term results among imatinib-resistant/intolerant patients with chronic phase chronic myeloid leukemia are favourable in daily clinical practice (Zackova D et al. Leuk Lymphoma, October 2020) (epub ahead of print) |
Examination of clinically-derived p210 BCR/ABL1 RhoGEF mutations in a murine model marrow transplantation of CML (Ciccarelli BT et al. Leuk Res, October 2020) |
| September 2020 | |
| Why is it critical to achieve a deep molecular response in chronic myeloid leukemia? (Branford S. Haematologica, September 2020) – open access publication |
CML – Not only BCR-ABL1 matters (Rinke J et al. Best Pract Res Clin Haematol, September 2020) |
| Breakpoints mapping of a t(9;22;12) chronic myeloid leukemia patient with e14a3 BCR-ABL1 transcript using nanopore sequencing (Zhao H et al. J Gene Med, September 2020) (epub ahead of print) |
Declaration of BCR-ABL1 independence (Zhao H and Deininger MW. Leukemia, September 2020) |
| Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia (Shanmunagathan N et al. Blood, September 2020) (epub ahead of print) |
Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells (Tanaka Y et al. Exp Hematol, September 2020) |
| Incidence of deep molecular responses and treatment-free remission in de novo CP-CMO patients (Etienne G et al. Cancers(Basel), September 2020) – open access publication |
Checkpoint kinase-1 inhibitors and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologenous recombination DNA damage repair (Fan Z et al. Oncol Rep, September 2020) (epub ahead of print) - open access publication |
| Erythropoietin treatment in chronic myeloid leukemia patients treated with frontline imatinib who developed anaemia (Cesini L et al. Eur J Hematol, September 2020) |
A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor chronic myeloid leukemia cells (He B et al. Biomed Pharmacother, September 2020) – open access publication |
| Treatment-free remission in chronic myeloid leukemia harbouring atypical BCR-ABL1 transcripts (Dragani M et al. Mediterr J Hematol Infect Dis, September 2020) – open access publication |
BCR-ABL allosteric inhibitors: Where we are and where we are going to (Carofiglio F et al. Molecules, September 2020) – open access publication |
| Unravelling surviving expression in chronic myeloid leukemia: Molecular interactions and clinical implications (Bernardo PS et al. Blood Rev, September 2020) |
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| Second-line dasatinib therapy improved compliance and deep molecular responses in imatinib-intolerant chronic myeloid leukemia patients (Markovic U et al. Anticancer Res, September 2020) |
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| Impact of the BCR-ABL1 transcript type on clinical and biological parameters and molecular response in patients with chronic myeloid leukemia (Nachi M et al. Hematol Oncol Stem Cell Ther, September 2020) – open access publication |
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| Response and adherence to nilotinib in daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotonib (Boons CCLM et al. Eur J Pharmacol, September 2020) – open access publication |
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| August 2020 | |
| Moving on from 2013 to 2020 European LeukemiaNet recommendations for treating chronic myeloid leukemia: what has changed over the 7 years? (Yilmaz U & Eskazan AE. Expert Rev Hematol, August 2020) (epub ahead of print) - open access publication |
SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem cell disorders (Kaiser A et al. Leukemia, August 2020 |
| A phase 1 study to evaluate the feasibility and efficacy of the addition of ropeginterferon alpha-2b to imatinib in patients with chronic phase chronic myeloid leukemia (CML) not achieving a deep molecular response (molecular remission 4.5) – AGMT-CML1 (Heibl S et al. Hematol Oncol, August 2020) (epub ahead of print) |
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses (Adnan Awad S et al. Leukemia, August 2020) (epub ahead of print) – open access publication |
| Treatment-free remission in chronic myeloid leukemia: the patient perspective and areas of unmet needs (Sharf G et al. Leukemia, August 2020) – open access publication |
Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML (Toda J et al. Oncogene, August 2020) – open access publication |
| Low-dose tyrosine kinase inhibitors before treatment discontinuation do not repair treatment-free remission in chronic myeloid leukemia patients: Results of a retrospective study (Cayassials E et al. Cancer, August 2020) – open access publication |
A high-content cytokine screen identifies myostatin propeptides as a positive regulator of primitive chronic myeloid leukemia cells (von Palffy S et al. Haematologica, August 2020) – open access publication |
| Epidural myeloid sarcoma a the presenting symptom of chronic myeloid leukemia blast crisis (Slouma M et al. Clin Rheumatol, August 2020) – open access publication |
Nuclear receptors as potential therapeutic targets for myeloid leukemia (Pan P & Chen X. Cells, August 2020) |
| Ponatinib therapy in recurrent Philadelphia chromosome-positive central nervous system leukemia with T315I mutation after Allo-HSCT (He JB et l. Int J Cancer, August 2020) – open access publication |
In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, August 2020) (epub ahead of print) – open access publication |
| Vascular events may predict the prognosis of patients with chronic myeloid leukemia (Ureshino H & Kamachi K. Int J Hematol, August 2020) – open access publication |
Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia (Greiner L et al. Int J Cancer, August 2020) – open access publication |
| Effect of age and comorbidities on the decline of glomerular filtration rate in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors (Lucijanic M & Krecak I. Int J Hematol, August 2020) – open access publication |
Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis |
| Use of generic imatinib as first-line treatment in patients with chronic myeloid leukemia (CML): the GIMS (Glivec to Imatinib Switch) study) (Genelli M et al. Blood Res, August 2020) (epub ahead of print) – open access publication |
Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis (Liu J et al. Oncol Lett, August 2020) – open access publication |
| Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo (Jyotsana N et al. Ann Hematol, August 2020) – open access publication |
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| July 2020 | |
| A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukemia (Smith G et al. Br J Haematol, July 2020) (epub ahead of print) – open access publication |
PVR and ICAM-1 on blast crisis CML stem and progenitor cells with TKI resistance confer susceptibility to NK cells (Kim N et al. Cancers (Basel), July 2020) |
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Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia |
Tyrosine kinase inhibitors induce alternative spliced BCR-ABL (Ins35bp) variant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, July 2020) – open access publication |
| Current treatment options for chronic myeloid leukemia patients failing second-generation tyrosine kinase inhibitors (García-Gutiérrez V & Hernández-Boluda JCC. J Clin Med, July 2020) – open access publication |
Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors (Rothe K et al. Cell Stem Cells, July 2020) (epub ahead of print) |
| Surrogate markers for treatment-free remission in patients with chronic myeloid leukemia (Ureshino H et al. Clin Lymphoma Myeloma Leuk, July 2020) (epub ahead of print) - open access publication |
Therapeutic inhibition of FcγRIIb signaling targets leukemia stem cells in chronic myeloid leukemia (Parting O et al. Leukemia, July 2020) (epub ahead of print) - open access publication |
| Comparison of BCR-ABL1 quantification in pheripheral blood and bone marrow using an International scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, July 2020) – open access publication |
Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells (Hallal R et al. J Cell Mol Med, July 2020) (epub ahead of print) – open access publication |
| Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia (Abaza Y et al. Am J Hematol, July 2020) (epub ahead of print) |
Targeting SKP2/BCR-ABL pathway with Diosmetin suppresses chronic myeloid leukemia proliferation (Liu Y et al. Eur J Pharmacol, July 2020) (epub ahead of print) |
| Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity (Janssen L et al. Haematologica, July 2020) |
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| Late molecular recurrences in patients with chronic myeloid leukemia experiencing treatment-free remission (Rousselot P et al. Blood Adv, July 2020) – open access publication |
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| Another set of guidelines for chronic myeloid leukaemia (Clark RE. Br J Haematol, July 2020) (epub ahead of print) |
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| Evidence of BCR-ABL1-positive progenitor spread in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML) (Turhan AG et al. Leuk Lymphoma, July 2020) |
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| Platelet function in patients with chronic myeloid leukemia treated with asciminib (Nesr G et al. Leuk Lymphoma, July 2020) (epub ahead of print) |
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| Timing for allogeneic hematopoietic cell transplantation (alloHCT) for chronic myeloid leukemia (CML) patients (Hu B et al. Leuk Lymphoma, July 2020) (epub ahead of print) |
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| June 2020 | |
| The EUTOS long-term survival (ELTS) score is superior to the Sokol score for predicting survival in chronic myeloid leukemia (Pfirrmann M et al. Leukemia, June 2020) (epub ahead of print) - open access publication |
An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TK et al. Blood, June 2020) (epub ahead of print) |
| First-line imatinib vs second- and third-generation TKI’s for chronic phase CML: a systematic review and data analysis (Vener C et al. Blood Adv, June 2020) – open access publication |
Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression (Sloma I et al. Haematologica, June 2020) (epub ahead of print) - open access publication |
| Influence of major BCR-ABL1 transcript subtype on outcomes in patients with chronic myeloid leukemia in chronic phase treated frontline with nilotinib (Gentham A et al. Oncotarget, June 2020) – open access publication |
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitation and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia (Losson H et al. Pharmacol Res, June 2020) (epub ahead of print) |
| Current strategies and future directions to achieve deep molecular response and treatment-free remission in chronic myeloid leukemia (Annunziata M et al. Front Oncol, June 2020) – open access publication |
Micro RNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2 mediated autophagy (Li YL et al. Hum Cell, July 2020) |
| Chronic myeloid leukemia prognosis and therapy: Criticisms and perspectives (Russo D et al. J Clin Med, June 2020) – open access publication |
Inhibition of USP1, a new partner of BCR-ABL, results in decrease of BCR-ABL level in K562 cells (Antonenko SV et al. Exp Oncol June 2020) |
| Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study (Hochhaus A et al. Leukemia, June 2020) (epub ahead of print) - open access publication |
Blastic transformation of BCR-ABL1 positive chronic myeloid leukemia through acquisition of CBFB-MYH11 and mutant KIT (Shoumariyeh K et al. B J Haematol, June 2020) (epub ahead of print) -open access publication |
| How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis from the monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, June 2020) – open access publication |
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| Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia (Pagani IS et al. Leuk Lymphoma, June 2020) (epub ahead of print) |
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| The clinical impact of time to response in de Novo accelerated-phase chronic myeloid leukemia (Ohanian M et al. Am J Hematol, June 2020) (epub ahead of print) |
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| May 2020 | |
| Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors (Hochhaus A et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis (Tang Z et al. Mod Pathol, May 2020) (epub ahead of print) |
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High-risk additional chromosomal abnormalities at low blast counts herald death by CML |
Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: Recent advances (Cumbo C et al. Cancer Manag Res, May 2020) – open access publication |
| Analysis of chronic myeloid leukemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission (Machova Polakova K et al. Leukemia, May 2020) (epub ahead of print) |
Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication |
| Delayed resistance to imatinib after 16 years of therapy in a patient with chronic myeloid leukemia (Kaur U et al. Br J Haematol, May 2020) (epub ahead of print) - open access publication |
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells (Lernoux M et al. Clin Epigenetics, May 2020) – open access publication |
| Prolonged treatment-free remission in chronic myeloid leukemia patients with previous BCR-ABL1 kinase domain mutations (Claudiadini S et al. Haematologica, May 2020) (epub ahead of print) - open access publication |
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia (Joshi SK. Leukemia, May 2020) (epub ahead of print) - open access publication |
| Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the last ten years (Dulucq S et al. Br J Haematol, May 2020) – open access publication |
Coexistance of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in CML: A case report (Shi XB et al. World J Clin Cases, May 2020) – open access publication |
| Treatment-free remission in patients with chronic myeloid leukemia (Ross DM and Hughes TP. Nat Rev Clin Oncol, May 2020) (epub ahead of print) |
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia (Yu C et al. Haematologica, May 2020) – open access publication |
| Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis (Wang Q et al. Leuk Lymphoma, May 2020) |
Recruiting TP53 to target chronic myeloid leukemia stem cells Grant S. Haematologica, May 2020 – open access publication http://www.haematologica.org/content/105/5/1172 |
| ABL genomic editing sufficiently abolished oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo (Chen SH et al. Cancers (Basel), May 2020) – open access publication |
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| Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (Ma CC et al. J Int Med Res, May 2020) – open access publication |
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| High-risk additional chromosomal abnormalities at low blast counts herald death by CML (Hehlmann R et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
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| Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication |
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| Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia (Kumar R et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
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| Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis (Xiao FY et al. Life Sci, May 2020) – open access publication |
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| Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (MA CC et al. J Int Med Res, May 2020) – open access publication |
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| April 2020 | |
| Response and resistance to BCR-ABL1-targeted therapies (Braun TP et al. Cancer Cell, April 2020) |
Nobiletin promotes megakaryocytic differentiation through the MAPK/ERK-dependent EGR1 expression and exerts anti-leukemic effects in human chronic myeloid leukemia (CML) K562 cells (Yen JH et al. Cells, April 2020) – open access publication |
| Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased killer cells (Irani YD et al. Br J Haemaol, April 2020) (epub ahead of print) – open access publication |
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR-ABL/AKT/mTOR pathway (Zhang Z et al. Int J Mol Med, April 2020) |
| Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia (Brümmendorf TH et al. Ann Hematol, April 2020) (epub ahead of print) - open access publication |
Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia (Gong Z et al. Br J Haematol, April 2020) (epub ahead of print) - open access publication |
| Venetoclax and BCR-ABL tyrosine kinase inhibitor combinations: outcome in patients with Philadelphia chromosome-positive advanced myeloid leukemias (Maiti A et al. Acta Haematol, April 2020) (epub ahead of print) |
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemia stem cells in CML (Lin H et al. Blood, April 2020) (epub ahead of print) |
| Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study (Cortes JE et al. Leukemia, April 2020) (epub ahead of print) – open access publication |
Response and resistance to BCR-ABL-1 targeted therapies (Braun TP et al. Cancer Cell, April 2020) |
| Metabolic analysis of patients with chronic myeloid leukemia and cardiovascular adverse events after treatment with tyrosine kinase inhibitors (Caocci et al. J Clin Med, April 2020) – open access publication |
GZD824 as a FLT3, FGFR1 and PDGFR-alpha inhibitor against leukemia in vitro and in vivo (Wang Y et al. Transl Oncol, April 2020) (epub ahead of print) - open access publication |
| Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring (Jabbour E and Kantarjian H. Am J Hematol, April 2020) (epub ahead of print) |
Basic knowledge on BCR-ABL1-positive extracellular vesicles (Jurj A et al. Biomark Med, April 2020) (epub ahead of print) |
| Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic-phase chronic myeloid leukemia based on early achievement of deep molecular response (MR4.5): The phase 2, multicenter N-Road study (Nishiwaki K et al. Cancer Med, April 2020) (epub ahead of print) - open access publication |
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients (Spiess D et al. Ann Hematol, April 2020) (epub ahead of print) – open access publication |
| The differentiated diagnosis of basophilia in patients undergoing BCR-ABL testing (Smith CJ et al. Am J Hematol, April 2020) (epub ahead of print) - open access publication |
A novel chimeric antigen receptor redirecting T-cell specificity towards CCD26+ cancer cells (Zhou S et al. Leukemia, April 2020) (epub ahead of print) |
| Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia (Hino M et al. Int J Hematol, April 2020) (epub ahead of print) |
TKIs induce alternative spliced BCR-ABLIns35bp variant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, April 2020) (epub ahead of print) - open access publication |
| How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis frontline monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, April 2020) (epub ahead of print) - open access publication |
Induction of CML-specific immune response through cross-presentation triggered by CTP-mediated BCR-ABL-derived peptides (Yang H et al. Cancer Lett, April 2020) (epub ahead of print) |
| Synthesis and characterization of Telmisartan-derived cell death modulators to circumvent imatinib resistance in chronic myeloid leukemia (Gust R et al. ChemMedChem, April 2020) (epub ahead of print) - open access publication |
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| Role of DNA damage response in suppressing malignant progression of chronic myeloid leukemia and Polycythemia Vera: Impact of different oncogenes (Stetka J et al. Cancers (Basel), April 2020) – open access publication |
|
| March 2020 | |
| TARGET: a survey of real-world management of chronic myeloid leukemia across 33 countries (Turkina A et al. Br J Haematol, March 2020) (epub ahead of publication) |
Correction of Bcl-x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse model (Zhang J et al. Br J Haematol, March 2020) (epub ahead of print) |
|
Risk stratification of chronic myeloid leukemia according to different prognostic scores |
An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TH et al. Blood, March 2020) (epub ahead of print) |
| Patient-initiated discontinuation of tyrosine kinase inhibitor for chronic myeloid leukemia (Langabeer SE et al. Case Rep Hematol, March 2020) – open access publication |
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and –resistant chronic myeloid leukemia cells (Jiang L et al. Eur J Pharmacol, March 2020) (epub ahead of print) – open access publication |
| European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia (Hochhaus A et al. Leukemia, March 2020) (epub ahead of print) – open access publication |
Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells (Shibata N et al. Oncogene, March 2020) (epub ahead of print) |
| Pharmacokinetics of dasatinib in hemodialysis patient with chronic myeloid leukemia and chronic kidney disease (Mori J et al. Int J Hematol, March 2019) (epub ahead of print) |
SIRT7: an influence factor in healthy aging and the development of age-dependet myeloid stem cell disorders |
| Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the new TARGET study 2nd line (Sakurai M et al. Int J Hematol, March 2020) (epub ahead of print) |
Ponatinib induces vascular toxicity through the Notch-1 signaling pathway (Madonna R et al. J Clin Med, March 2020) – open access publication |
| The multi-tyrosine kinase inhibitor ponatinib for chronic myeloid leukemia: Real-world data (Luciano L et al. Eur J Haematol, March 2020) (epub ahead of print)- open access publication |
Involvement of MCL-1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315l(+) Ph+leukemia cells (Inoue C et al. Biochem Biophys Res Commun, March 2020) (epub ahead of print) |
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Novel therapeutic approaches in chronic myeloid leukemia |
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Experience of living with chronic myeloid leukemia and adhering to tyrosine kinase inhibitors: A thematic synthesis of qualitative studies |
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BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia |
|
| Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia (Eskazan AE. Leukemia, March 2020) (epub ahead of print) |
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| Does patient sex play a role in treatment-free remission in chronic myeoid leukemia? (Ureshino H et al. Int J Hematol, March 2020) (epub ahead of print) |
|
| Significance of lymphocyte count, monocyte count, and lymphocyte-to-monocyte ratio in predicting molecular response in patients with chronic myeloid leukemia: A single center experience (Pepedil-Tanrikulu F et al. Clin Lab, March 2020) |
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| Influence of proton pump inhibitors and H2-receptor antagonists on the efficacy and safety of dasatinib in chronic myeloid leukemia patients (Koutake Y et al. Int J Hematol, March 2020) (epub ahead of print) |
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| February 2020 | |
| Side-effect profile and outcomes of ponatinib in the treatment of chronic myeloid leukemia (Chan O et al. Blood Adv, February 2020) – open access publication |
Phosphorylation-dependent differences in CXCR4-LASP-AKT1 interaction between breast cancer and chronic myeloid leukemia (Butt E et al. Cells, February 2020) – open access publication |
| Prospects of achieving treatment-free remission in chronic myeloid leukemia) (Saglio G et al. Br J Haematol, February 2020) (epub ahead of print) - open access publication |
Aberrant RAG-mediated recombination contributes in lymphoid blast crisis of chronic myeloid leukemia (Thomson DW et al. Leukemia, February 2020) (epub ahead of print) |
| Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the past ten years (Dulucq S et al. Br J Hematol, February 2020) (epub ahead of print) |
Model-based inference and classification of immunological control mechanism from TKI cessation and dose reduction in CML patients (Hähnel T et al. Cancer Res, February 2020) (epub ahead of print) |
| Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results analysis (Wang Q et al. Leuk Lymphoma, January 2020) (epub ahead of print) |
Comparison of BCR-ABL 1 quantification in peripheral blood and bone marrow using an international scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, February 2020) (epub ahead of print) |
| Mechanisms of cardiovascular toxicity of BCR-ABL 1 tyrosine kinase inhibitors in chronic myelogenous leukemia (Gustafson D et al. Curr Hematol Rep, February 2020) (epub ahead of print) |
Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia (Huang W et al. Leukemia, February 2020) (epub ahead of print) - open access publication |
| A single center evaluation of cost savings related to treatment-free remission in chronic myeloid leukemia patients: the prerequisites of a pharmaco-economy larger study (Etienne G et al. Br J Haematol, February 2020) (epub ahead of print) |
SRSF1 mediates cytokine induced impaired imatinib sensitivity in chronic myeloid leukemia (Sinnakannu JK et al. Leukemia, February 2020) (epub ahead of print) |
| Novel illumine-based next generation sequencing approach with one-round amplification provides early and reliable detection of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia (Romzova M et al. Br J Hematol, February 2020) (epub ahead of print) |
Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia (Adnan Awad S et al. Blood Adv, February 2020) – open access publication |
| What’s NEXT for CML-NGS mutation screening? (Shanmunagathan N et al. Blood, February 2020) |
The landscape of BCR-ABL mutations in patients with Philadelphia chromosome-positive leukaemias in the era of second-generation tyrosine kinase inhibitors |
| DNA damage and DNA damage response in chronic myeloid leukemia (Popp HD et al. Int J Mol Sci, February 2020) – open access publication |
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Nanomaterials as magic bullets in the treatment of leukemia |
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| January 2020 | |
| Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia (Masarova L et al. Cancer, January 2020) (epub ahead of print) |
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin SCT/TAL-1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication |
| Long-term results of frontline dasatinib in chronic myeloid leukemia (Maiti A et al. Cancer, January 2020) (epub ahead of print) |
How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study (Zhang H et al. J Biomol Strat Dyn January 2020) |
| Molecular dynamics during reduction of TKI dose reliably identify molecular recurrence after treatment cessation of CML (Gottschalk A et al. Blood, January 2020) (epub ahead of print) |
Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukemia patients stopping tyrosine kinase inhibitor therapy |
A randomized phase II trial of hydroxychloroquine and imatinib alone for patients with chronic myeloid leukemia in major cytogenetic response with residual disease |
The leukemia stem cell: similarities, differences and clinical prospects in CML and AML (Vetrie D et al. Nat Rev Cancer, January 2020) (epub ahead of print) |
| Treatment patterns and deep molecular response in chronic-phase – chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study (Cortes J et al. Leuk Lymphoma, January 2020) |
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy (Kinstrie R et al. Leukemia, January 2020) (epub ahead of print) |
| What are the considerations for tyrosine kinase inhibitor discontinuation in chronic phase chronic myeloid leukemia? (Harrington P et al. Expert Rev Hematol, January 2020) (epub ahead of print) |
Knock-out of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance (Herrmann AD et al. J Cell Mol Med, January 2020) (epub ahead of print) – open access publication |
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Successful planned pregnancy through vitrified-warmed embryo transfer in a women with chronic myeloid leukemia: Case report and literature review |
Defining the niche interactions to target chronic myeloid leukemia stem cells (Mitchell R et al. Haematologica, January 2020) – open access publication |
| Treatment-free remission after first-line dasatinib treatment in patients with chronic myeloid leukemia in the chronic phase: the D-NewS study of the Kanto CL Study Group (Yamaguchi H et al. Int J Hematol, January 2020) (epub ahead of print) |
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin – SCL/TAL1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication |
| Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells (Grandjenette C et al. Cancer Lett, January 2020) |
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iCMLf Run.Ride.Cure 2020 - Wall of Fame
iCMLf Run.Ride.Cure 2020 Wall of Fame
This year the annual John Goldman charity run was virtual. With the help of 16 dedicated participants, including; previous preceptors, CML patients, colleagues and supporters - among them a six year old and an eight year old - we have raised more than $9,200 through the iCMLf Run.Ride.Cure 2020.
Thanks to everyone for their contributions!
iCMLf Run.Ride.Cure 2020 - Wall of Fame
This year the annual John Goldman charity run was virtual. With the help of 16 dedicated participants, including; previous preceptors, CML patients, colleagues and supporters - among them a six year old and an eight year old - we have raised more than $9,200 through the iCMLf Run.Ride.Cure 2020.
Thanks to everyone for their contributions!
CML Publications 2019
| Clinical Publications | Scientific Publications |
| December 2019 | |
| Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEA CML WP (Baccarani M et al. Blood Adv. December, 2019) – open access publication |
Comprehensive analyses of safety and efficacy towards individualizing imatinib dosage in patients with chronic myeloid leukemia (Shin H et al. Int J Hematol, December 2019) (epub ahead of print) |
| Prospective assessment of NGS-detectable mutations in CML patients with non-optimal response: the NEXT-in CML study (Soverini S et al. Blood, December 2019) (epub ahead of print) |
A novel inhibitor of STAT5 signaling overcomes chemotherapy resistance in myeloid leukemia cells (Brachet-Botineau M et al. Cancers (Basel), December 2019) |
| Tyrosine kinase inhibitors in leukemia and cardiovascular events: From mechanisms to patient care (Manouchehri A et al. Arterioscler Thromb Vasc Bio, December 2019) (epub ahead of print) – open access publication |
Marrow fibrosis is an independent predictor of hematological toxicity of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia (Ni J et al. Leuk Lymphoma, December 2019) (epub ahead of print) |
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Beyond the comfort zone of deep molecular response: discontinuation in major molecular response chronic myeloid leukemia |
Reconstituion of NK cells expressing KIR3DL1 is associated with reduced NK cell activity and relapse of CML after allogeneic hematopoietic stem cell transplantation |
| Feasibility study of switching to nilotinib after first-line imatinib in the chronic phase of chronic myeloid leukemia (Chen Y et al. Clin Lymphoma Myeloma Leuk, December 2019) |
Macrophage protects mycoplasma-infected chronic myeloid leukemia cells from NK cell killing (Choo QWW et al. Immunol Cell Biol, December 2019) (epub ahead of print) |
| Asciminib in chronic myeloid leukemia after ABL kinase inhibitor failure (Hughes TP et al. N Eng J Med, December 2019) |
Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper (Soverini S et al. J Hematol Oncol, December 2019) - OPEN ACCESS |
| Do persons with chronic myeloid leukemia have normal or near normal survival? (Radivoyevitch T et al. Leukemia, December 2019) (epub ahead of print) - OPEN ACCESS |
Chronic myeloid leukemia: The danger of not knowing your BCR-ABL1 transcript (Sharplin K et al. Leuk Res, December 2019) |
| Mechanisms of disease progression and resistance to tyrosine kinase inhibitor therapy in chronic myeloid leukemia: An update (Bavaro L et al. Int J Mol Sci, December 2019) - OPEN ACCESS |
Preclinical development of a novel BCR-ABL T315I inhibitor against chronic myeloid leukemia (Gupta P et al. Cancer Lett, December 2019) (epub ahead of print) |
| Utility of therapeutic drug monitoring of imatinib, nilotinib, and dasatinib in chronic myeloid leukemia: A systematic review and meta-analysis (García-Ferrer M et al. Clin Ther, December 2019) |
The predictive value of intracellular imatinib levels in newly diagnosed chronic myeloid leukemia (Hillis S et al. Leuk Res, December 2019) (epub ahead of print) |
| Treatment-free remission in chronic myeloid leukemia (Molica M et al. Clin Adv Hematol Oncol, December 2019) |
Blast crisis of chronic myeloid leukemia with plasmacytoid dentritic cell phenotype associated with a rare fusion transcript, e13a3 BCR-ABL1 (Xu D et al. Leuk Lymphoma, December 2019) |
| Management of ponatinib in patients with chronic myeloid leukemia with cardiovascular risk factors (Santoro M et al. Chemotherapy, December 2019) (epub ahead of print) |
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| November 2019 | |
| Sudden blastic transformation in treatment-free remission chronic myeloid leukemia (Alfayez M et al. Br J Haematol, November 2019) |
Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission |
| New approaches to molecular monitoring in CML (and other diseases) (Radich J et al. Blood, November 2019) |
Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin (Lauseker M et al. Am J Hematol, November 2019) |
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Compexity of chronic-phase CML management after failing a second-generation TKI |
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells (Tanaka A et al. J Exp Med, November 2019) (epub ahead of print) |
| Towards a personalized treatment of patients with chronic myeloid leukemia (Rabian F et al. Curr Hematol Malig Rep, November 2019) (epub ahead of print) |
Role of cancer immunology in chronic myelogenous leukemia (Ureshino H et al. Leuk Res, November 2019) (epub ahead of print) |
| The TKI-free duration after a first discontinuation attempt that failed in CP CML patients is a predictive factor of TKI-free remission after a second attempt (Legros L et al. Blood, November 2019) |
CDK4/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1T315l clones in TKI-resistant CML (Schneeweiss-Gleixner M et al. EBioMedicine, November 2019) (epub ahead of print) |
| Prognostication of molecular relapses after dasatinib or nilotinib discontinuation in chronic myeloid leukemia (CML): A FI-LMC STOP 2G-TKI study update (Rea D et al. Blood, November 2019) |
Repurposing drugs in silico methods to target BCR kinase domain in chronic myeloid leukemia (Natarjan A et al. Asian Pac J Cancer Prev, November 2019) http://journal.waocp.org/article_88830.html |
| Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also bEarly management of CML (Shanmunagathan N et al. Curr Hematol Malig Rep, November 2019) (epub ahead of print) |
Druggable biochemical pathways and potential therapeutic alternatives to target leukemia stem cells and eliminate the residual disease in chronic myeloid leukemia |
| Introducing a predictive score for successful treatment-free remission in chronic myeloid leukemia (CML) (Claudiani S et al. Blood, November 2019) |
Epigenetic mechanisms underlying the therapeutic effects of HDAC inhibitors in chronic myeloid leukemia (Lernoux M et al. Biochem Pharmacol, November 2019) (epub ahead of print) |
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Early management of CML |
The hidden pathogenesis of CML: Is BCR-ABL1 the first event? (Shanmunagathan N, Branford S. Curr Hematol Malig Rep, November 2019) (epub ahead of print) |
| October 2019 | |
| Comparison of real-time quantitative PCR and digital droplet PCR for BCR-ABL1 monitoring in patients with chronic myeloid leukemia (Franke GN et al. J Mol Diagn, October 2019) (epub ahead of print) |
Combining the allosteric inhibitor asciminib with ponatinib suppresses emergence of and restores efficacy against highly resistant BCR-ABL1 mutants (Eide CA et al. Cancer Cell, October 2019) |
| Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study (Shah NP et al. Leuk Lymph, October 2019) (epub ahead of print) |
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| Chronic myeloid leukemia: the concepts of resistance and persistence and the relationship with the BCR-ABL1 transcript type (Baccarani et al. Leukemia, October 2019) |
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| September 2019 | |
| Prolonged treatment free remission in chronic myeloid leukemia patients with previous BCR-ABL1 kinase domain mutations (Claudiani S et al. Haematologica, September 2019) (epub ahead of print) |
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways (Magistroni V et al. Haematologica, September 2019 |
| Long-term follow-up of lower dose dasatinib (50 mg daily) as frontline therapy in newly diagnosed chronic-phase chronic myeloid leukemia (Naqvi K et al. Cancer, September 2019) (epub ahead of print) |
Efficacy of dasatinib against ponatinib-resistant chronic myeloid leukemia cells (Okabe S et al. Leuk Lymphoma, September 2019) (epub ahead of print) |
| New approaches of molecular monitoring in CML (and other diseases) (Radich J et al. Blood, September 2019) (epub ahead of print) |
KLF4 represses DYRK2 inhibition of self-renewal and survival through c-Myc and p53 in leukemia stem/progenitor cells (Park CS et al. Blood, September 2019) (epub ahead of print) |
| Health-related quality of life of newly diagnosed chronic myeloid leukemia patients treated with first-line dasatinib versus imatinib therapy (Efficace F et al. Leukemia, September 2019) (epub ahead of print) |
MiR-96 acts as a tumor suppressor via targeting the BCR-ABL1 oncogene in chronic myeloid leukemia blastic transformation (Huang T et al. Biomed Pharmacother, September 2019) (epub ahead of print) |
| Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt) (Nagafuji K et al. J Hematol, September 2019) (epub ahead of print) |
The dynamic of TNF and IL6 gene expression in chronic myeloid leukemia patients reveals early responders to imatinib (Bestach Y et al. Leuk Res, September 2019) (epub ahead of print) |
| Efficacy and safety of bosutinib in chronic phase CML patients developing pleural effusion under dasatinib therapy (Tiribelli M et al. Ann Hematol, September 2019) |
The interaction of tumor cells and myeloid-derived suppressor cells in chronic myelogenous leukemia (Xu H et al. Leuk Lymphoma, September 2019) (epub ahead of print) |
| Efficacy and safety of generic imatinib after switching from original imatinib in patients treated for chronic myeloid leukemia in the United States (Abou Dalle I et al. Cancer Med, September 2019) (epub ahead of print) |
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| Tyrosine kinase inhibitors in the clinical setting: A conundrum of choices (Bankar A et al. Acta Haematol, September 2019) |
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Internet-assisted cognitive behavioral intervention for targeted therapy-related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial |
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| August 2019 | |
| Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin (Lauseker M et al. Am J Hematol, August 2019) (epub ahead of print) |
BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis (Kidoguchi K et al. Ann Hematol, August 2019) (epub ahead of print) |
| Chronic myeloid leukemia: the concepts of resistance and persistence and the relationship with the BCR-ABL1 transcript type (Baccarani M et al. Leukemia, August 2019) (epub ahead of print) |
Continuous cytostatic effects of BCR-ABL tyrosine kinase inhibitors (TKI’s) after washout in human leukemic K562 cells (Aoyama T et al. Biol Pharm Bull, August 2019) (epub ahead of print) |
| Treatment patterns and deep molecular response in chronic-phase – chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study (Cortes J et al. Leuk Lymphoma, August 2019) (epub ahead of print) |
Identification of key candidate targets and pathways for the treatment of leukemia using bioinformatics analysis (Li H et al. Mol Genet Genomic Med, August 2019) (epub ahead of print) |
| Lenalidomide maintenance treatment after imatinib discontinuation: results of a phase 1 clinical trial in chronic myeloid leukemia (Ross DM et al. Br J Haematol, August 2019) |
Bone marrow microenvironment: The guardian of leukemia stem cells (Houshmand M et al. World J Stem Cells, August 2019) |
| Treatment patterns and deep molecular response in chronic phase chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study (Cortes J et al. Leuk Lymphoma, August 2019) (epub ahead of print) |
BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of surviving and cyclin D1 in chronic myeloid leukemia cells (Moriyama K et al. Int J Hematol, August 2019) (epub ahead of print) |
| Discontinuation of tyrosine kinase inhibitors in patients with chronic myelogenous leukemia – You can do this if you read the instructions (Schiffer CA. Haematologica, August 2019) |
Combined inhibition of MDM2 and BCR-ABL tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model (Carter BZ et al. Haematologica, August 2019) (epub ahead of print) |
| The efficacy of tolvaptan in treating dasatinib-induced pleural effusions in patients with chronic myelogenous leukemia (Aoyama R et al. J Cardiol, August 2019) (epub ahead of print) |
Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia (Yu C et al. Haematologica, August 2019) (epub ahead of print) |
| Nilotinib efficacy, safety, adherence and impact on quality of life in newly diagnosed patients with chronic myeloid leukemia in chronic phase: a prospective observational study in daily clinical practice (Huguet F et al. Br J Haematol, August 2019) (epub ahead of print) |
BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of surviving and Cyclin D1 in chronic myeloid leukemia cells (Moriyamo K et al. Int J Hematol, August 2019) (epub ahead of print) |
| Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in real-life practice (Caocci G et al. Ann Hematol, August 2019) |
Targeting small molecule tyrosine kinases by Polyphenols: New move towards anti-tumor drug discovery (Sakle NS et al. Curr Drug Discov Technol, August 2019 (epub ahead of print) |
| New approaches and treatment combinations for the management of chronic myeloid leukemia (Westerweel PE et al. Front Oncol, August 2019) |
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| FISH versus real-time quantitative PCR for monitoring of minimal residual disease in chronic myeloid leukemia patients with tyrosine kinase inhibitor therapy (Haidary AM et al. Malays J Pathol, August 2019) |
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| Late mortality after bone marrow transplant for chronic myelogenous leukemia in the context of prior tyrosine kinase exposure: A Blood or Marrow transplant Survivor Study (BMTSS) Report (Wu J et al. Cancer, August 2019) (epub ahead of print) |
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| Outcome of very elderly chronic myeloid leukemia patients treated with imatinib frontline (Crugnola M et al. Ann Hematol, August 2019) (epub ahead of print) |
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| Recommendations from a Portuguese expert group for discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia patients in clinical practice (Almeida A et al. Acta Med Port, August 2019) (epub ahed of print) |
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| July 2019 | |
| Longer treatment duration and history of osteoarticular symptoms predispose to tyrosine kinase inhibitor withdrawal syndrome (Berger MG et al. Br J Haematol, July 2019) (epub ahead of print) |
Oncurrence of chromosomal abnormalities in Philadelphia chromosome-negative metaphases in patients with chronic-phase chronic myeloid leukemia undergoing TKI treatments (Sheng G et al. Leuk Lymphoma, July 2019) (epub ahead of print) |
| Incidence and outcome of BCR-ABL mutated chronic myeloid leukemia patients who failed to tyrosine kinase inhibitors (Etienne G et al. Cancer Med, July 2019) (epub ahead of print) |
Targeting BCR-ABL 1 in chronic myeloid leukemia by PROTAC-mediated targeted protein degradation (Burslem GM et al. Cancer Res, July 2019) (epub ahead of print) |
| Evaluation of residual disease and TKI duration are predictive factors for molecular recurrence after stopping imatinib first-line in chronic phase CML patients (Nicolini FE et al. Clin Cancer Res, July 2019) (epub ahead of print) |
Killer immunoglobulin-line receptor genotypes and chronic myeloid leukemia outcomes after imatinib cessation for treatment-free remission (Dumas PY et al. Cancer Med, July 2019) (epub ahead of print) |
| Clinical efficacy and safety of first-line nilotinib therapy and evaluation of the clinical utility of the FRET-based drug sensitivity test (Kondo T et al. Int J Hematol, June 2019) (epub ahead of print) |
Infliximab together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia (Herrmann O et al. BMC Cancer, July 2019) |
| Digital droplet PCR at the time of TKI discontinuation in chronic phase chronic myeloid patients is predictive of treatment-free remission outcome (Colafigli G et al. Hematol Oncol, July 2019) (epub ahead of print) |
Human BCR-ABL1 induces chronic myeloid leukemia-like disease in zebrafish (Xu M et al. Haematologica, July 2019) (epub ahead of print) |
| True value of second-generation TKI’s as first-line therapy in chronic myeloid leukemia (Andrews CN et al. Lancet Haematol, June 2019) (epub ahead of print) |
Clinical characteristics and prognostic significance of chronic myeloid leukemia with rare BCR-ABL1 transcripts (Xue M et al. Leuk Lymphoma, July 2019) (epub ahead of print) |
| Front-line use of tryrosine kinase inhibitors in chronic phase chronic myeloid leukemia: Practice considerations (Reff MJ et al. J Oncol Pharm Pract, July 2019) (epub ahead of print) |
Determination of serum imatinib and it’s metabolite in patients with chronic myeloid leukemia (Onmaz DE et al. Clin Chim Acta, July 2019) (epub ahead of print) |
| Tyrosine kinase inhibitors available for chronic myeloid leukemia: Efficacy and safety (García-Gutiérrez V et al. Front Oncol, July 2019) |
The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in PH+ leukemia and sensitizes for ABL kinase inhibitors (Bahjat M et al. Cell Cycle, July 2019) (epub ahead of print) |
| Differences in treatment and monitoring of chronic myeloid leukemia with regard to age, but not sex: results from a population-based study (Lauseker M et al. Eur J Haematol, July 2019) (epub ahead of print) |
Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/line cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment (Trojani A et al. PLoS One, July 2019) (epub ahead of print) |
| Comparison of BCR-ABL transcript variants between patients with chronic myeloid leukemia and leukemia cell lines (DE Oliveira Sales L et al. In Vivo, July-Aug 2019) |
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| June 2019 | |
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Neurotoxic events associated with BCR-ABL1 tyrosine kinase inhibitors: a case series |
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells (Abraham A et al. J Clin Invest, June 2019) |
| De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukemia (DESTINY): a non-randomized, phase 2 trial (Clark RE et al. Lancet Haematol, June 2019) (epub ahead of print) |
Variant specific discrepancy when quantitating BCR-ABL1 e13a2 and e14a2 transcripts using the Europe Against Cancer qPCR assay. Is dPCR the key? (Bernardi S et al. Eur J Haematol, June 2019) (epub ahead of print) |
| Treatment value of second-generation BCR-ABL1 tyrosine kinase inhibitors compared with imatinib to achieve treatment-free remission in patients with chronic myeloid leukemia: a modeling study (Shih YT et al. Lancet Haematol, June 2019) (epub ahead of print) |
Knockdown of ribonucelotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib-based therapy (Liu C et al. Oncol Rep, June 2019) (epub ahead of print) |
| Beyond the comfort zone of deep molecular response: discontinuation in major molecular response chronic myeloid leukemia (Dragani M et al. Leuk Lymphoma, June 2019) (epub ahead of print) |
Clinical implications of simultaneous occurrence of variant Philadelphia translocations in chronic myeloid leukemia (Trivedi P et al. J Assoc Genet Technol, 2019) |
| Therapy de-escalation before stopping in chronic myeloid leukemia (Mustjoki S et al. Lancet Haematol, June 2019) (epub ahead of print) |
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| Planned pregnancy in female patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy (Dou X et al. Oncologist, June 2019) (epub ahead of print) |
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| Is there a role for dose modification of TKI therapy in CML? (Copland M. Curr Hematol Malig Rep, June 2019) (epub ahead of print) |
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| May 2019 | |
| NCCN Guidelines updates: Discontinuing TKI therapy in the treatment of chronic myeloid leukemia (Shah NP et al. J Natl. Compr Canc Netw, May 2019) |
Gene expression signature that predicts early molecular response failure in chronic-phase CML patients on frontline imatinib (Kok CH et al. Blood Adv, May 2019) |
| Can Chronic-Phase Chronic Myeloid Leukemia Patients Achieve Optimal and Durable Responses after Two Failed TKI Treatments? Real-World Evidence Data (Breccia M et al. Acta Haematol, May 2019) (epub ahead of print) |
Outcomes of patients with chronic myeloid leukemia (CML-CP) after discontinuation of frontline ponatinib therapy (Boddu P et al. Leuk Lymphoma, May 2019) (epub ahead of print) |
| Ten-year outcome of chronic-phase chronic myeloid leukemia patients treated with imatinib in real life (Molica M et al. Ann Hematol, May 2019) (epub ahead of print |
Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors (Nteliopoulos G et al. Haematologica, May 2019) (epub ahead of print) |
| Patients’ perspective on the definition of cure in chronic myeloid leukemia (Flynn KE et al. Leuk Res, May 2019) |
The proportion of different transcript types in chronic myeloid leukemia: An international review (Baccarani M et al. Leukemia, May 2019) |
| Risk and outcomes of second malignant neoplasms in chronic myeloid leukemia survivors (Jamy O et al. Leuk Res, May 2019) (epub ahead of print) |
Precision tyrosine kinase inhibitor dosing in chronic myeloid leukemia |
| Current outlook on drug resistance in chronic myeloid leukemia (CML) and potential therapeutic options (Sundaram DNM et al. Drug Discov Today, May 2019) (epub ahead of print) |
Digital PCR in myeloid malignancies: Ready to replace quantitative PCR? |
| Influence of glutathione S-transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment response (Rostami G et al. Mol Genet Genomic Med, May 2019) (epub ahead of print) |
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| Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo (Jyotsana N et al. Ann Hematol, May 2019) (epub ahead of print) |
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| Validation of a Drosophila model of wild type and T315l mutated BCR-ABL1 in chronic myeloid leukemia: An effective platform for treatment screening (Al Outa A et al. Haemotologica, May 2019) (epub ahead of print) |
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| PF-114, a novel selective inhibitor of BCR-ABL tyrosine kinase, is a potent inducer of apoptosis in chronic myelogenous leukemia cells (Ivanova ES et al. Int J Oncol, May 2019) (epub ahead of print) |
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Chronic myeloid leukemia stem cells |
| April 2019 | |
| A phase 2 study of alpha interferon for molecularly measurable residual disease in chronic myeloid leukemia after allogeneic hemotopoietic cell transplantation (Bezerra ED et al. Leuk Lymphoma, April 2019) |
Antitumor efficacy of arsenal/interferon in preclinical models of chronic myeloid leukemia resistant to tyrosine kinase inhibitors |
| The outcomes of chronic myeloid leukemia patients with molecular warning responses during imatinib treatment according to the European LeukemiaNet 2013 recommendations (Soysal T et al. Clin Lymphoma Myeloma Leuk, April 2019) (epub ahead of print) |
The vascular bone marrow niche influences outcomes in chronic myeloid leukemia via the E-selectin-SCL/TAL1-CD44 axis |
| Patient-reported outcomes in the phase 2 BEFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia (Cortes JE et al. J Cancer Res Clin Oncol, April 2019) (epub ahead of print) |
Modelling the safe minimum frequency of molecular monitoring for CML patients attempting treatment-free remission (Shanmuganathan N et al. Blood, April 2019) (epub ahead of print) |
| Matching-adjusted indirect comparison of bosutinib, dasatinib, and nilotinib on survival and major cytogenetic response for treatment of second-line chronic phase chronic myeloid leukemia (Cortes JE et al. Curr Med Res Opin, April 2019) (epub ahead of print) |
Compound mutations in CML – imaginary bogeyman or real arch-nemesis? (Yeung DT. Leuk Res, April 2019) |
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Exploring patient decision making regarding discontinuation of tyrosine kinase inhibitors for chronic myeloid leukemia |
Variant specific discrepancy when quantitating BCR-ABL1 e13a2 and e14a2 transcripts using the Europe against cancer qPCR assay |
| Results of the European survey on the assessment of deep molecular response in chronic phase CML patients during tyrosine kinase inhibitor (Möbius S et al. J Cancer Res Clin Oncol, April 2019) (epub ahead of print) |
Predictive value of early molecular response for deep molecular response in chronic phase of chronic myeloid leukemia (Wang R et al. Medicine, April 2019) |
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Anthropometric facts and risk of myeloid leukaemias and myelodysplastic syndromes: a prospective study and meta-analysis |
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| March 2019 | |
| MR4 sustained for 12 months is associated with stable deep molecular responses in chronic myeloid leukemia (Claudiani S et al. Haematologica, March 2019) (epub ahead of print) |
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitors (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) (Wu J et al. Cancer Biol Ther, March 2019) (epub ahead of print) |
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Lenalidomine maintenance after imatinib discontinuation: results of a phase 1 clinical trial in chronic myeloid leukemia |
Rates of deep molecular response by digital and conventional PCR with frontline nilotinib in newly diagnosed chronic myeloid leukemia: a landmark analysis |
| Nilotinib in the treatment of chronic myeloid leukemia (Sacha T et al. Future Oncol, March 2019) |
TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation (Uchida E et al. Int J Oncol, March 2019) (epub ahead of print) |
| Analysis of cardiovascular and arteriothrombotic events in chronic-phase CML patients after frontline TKI’s (Jain P et al. Blood Adv, March 2019) |
A synergistic combination against chronic myeloid leukemia: An intra-molecular mechanism of communication in BCR-ABL1 resistance (El Rashedy AA et al. Protein J, March 2019) (epub ahead of print) |
| Arterial occlusive events in chronic myeloid leukemia patients treated with ponatinib in the real-life practice are predicted by the Systematic Coronary Risk Evaluation (Score) chart (Caocci G et al. Hematol Oncol, March 2019) (epub ahead of print) |
Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling (Kuepper MK et al. Leukemia, March 2019) (epub ahead of print) |
| Skeletal muscle toxicity associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia (Janssen L et al. Leukemia, March 2019) (epub ahead of print) |
Impact of additional chromosomal aberrations on the disease progression of chronic myelogenous leukemia (Krishna Chandran R et al. Front Oncol, March 2019) (epub ahead of print) |
| Incidence of second malignancies in patients with chronic myloid leukemia in the era of tyrosine kinase inhibitors (Sasaki K et al. Int J Hematol, March 2019) (epub ahead of print) |
Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact an inclusion of CML patients in stopping trials (Spiess B et al. PLos One, March 2019) |
| Novel tyrosine kinase inhibitors for patients with inadequate response in chronic myeloid leukemia (Mauro MJ. Curr Opin Hematol, March 2019) |
Role of natural killer cells for immunotherapy in chronic myeloid leukemia (Review) (Lee HR et al. Oncol Rep, March 2019) (epub ahead of print) |
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Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
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Can increased immunogenicity in chronic myeloid leukemia improve outcomes? |
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Can increased immunogenicity in chronic myeloid leukemia improve outcomes? |
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| February 2019 | |
| Observational study of chronic myeloid leukemia Italian patients who discontinued tyrosine kinase inhibitors in clinical practice (Fava C et al. Haematologica, February 2019) (epub ahead of print) |
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways (Magistroni V et al. Haematologica, February 2019) (epub ahead of print) |
| Bone marrow fibrosis associated with long-term imatinib therapy: resolution after switching to a second-generation TKI (Shanmunagathan N et al. Blood Adv, February 2019) |
Single nucleotide polymorphism in PTEN-Long gene: A risk factor in chronic myeloid leukemia (Ferri C et al. Gene, February 2019) (epub ahead of print) |
| Impact of second decline rate of BCR-ABL1 transcript on clinical outcome of chronic phase chronic myeloid leukemia patients on imatinib first-line (Dulucq S et al. Ann Hematol, February 2019) (epub ahead of print) |
PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL 1 dependent (Nandagopalan SR et al. Int J Biochem Cell Biol, February 2019) (epub ahead of print) |
| Chronic myeloid leukaemia in pregnancy: call for guidelines (Pallavee P et al. J Obste Gynaecol, February 2019) (epub ahead of print) |
Analysis of major BCR-ABL1 mRNA by digital polymerase chain reaction is useful for prediction of international scale (Furuya D et al. Int J Clin Oncol, February 2019) (epub ahead of print) |
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The spectrum of musculoskeletal symptoms in patients with chronic myeloid leukemia after stopping tyrosine kinase inhibitors |
Imatinib treatments have long-term impact on placentation and embryo survival (Salem W et al. Sci Rep, February 2019) |
| Everolimus in combination with imatinib overcomes resistance in chronic myeloid leukemia (Alves R et al. Med Oncol, February 2019) |
Novel mutations in the kinase domain of BCR-ABL gene causing imatinib resistance in chronic myeloid leukemia patients |
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Dasatinib for chronic myelogenous leukemia improves skin symptoms of systemic sclerosis |
High circ_100053 predicts a poor outcome for chronic myeloid leukemia and is involved in imatinib resistance (Ping L et al. Oncol Res, February 2019) |
| Efficacy and safety of tyrosine kinase inhibitors for newly myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system (Kizaki M et al. Int J Hematol, February 2019) (epub ahead of print) |
MiR-378 promoted cell proliferation and inhibited apoptosis by enhance stem cell properties in chronic myeloid leukemia K562 cells |
| January 2019 | |
| Thrombotic microangipathy as a cause for cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib (Latifi Y et al. Blood, January 2019) (epub ahead of print) |
The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia: An international overview (Baccarani M et al. Leukemia, January 2019) (epub ahead of print) |
| Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience (Chamoun K et al. J Hematol Oncol, January 2019) |
Prediction of ALK mutations mediating ALK-TKI’s resistance and drug re-purposing to overcome the resistance (Okada K et al. E-Bio Medicine, January 2019) (epub ahead of print) |
| The effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia (Lasica M et al. Leuk Lymphoma, January 2019) (epub ahead of print) |
The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia: An international overview (Baccarani M et al. Leukemia, January 2019) (epub ahead of print) |
| Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience (Chamoun K. J Hematol Oncol, January 2019) |
New tool for monitoring molecular response in patients with chronic myeloid leukemia (Badar T et al. Appl Immunohistochem Mol Morphol, January 2019) |
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Thrombotic microangipathy as a cause for cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib |
NKG2A down-regulation by dasatinib enhances natural killer cytotoxicity and accelerates effective treatment responses in patients with chronic myeloid leukemia (Chang MC et al. Front immunol, January 2019) |
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Long-term disease control in chronic myeloid leukemia |
A novel naphtoquine-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells (Martín-Rodríguez P et al. Front Pharmacol, January 2019) |
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The case for real-world evidence in the future of clinical research on chronic myeloid leukemia |
Bone mesenchymal stromal cells exhibit functional inhibition but no chromosomal aberrations in chronic myelogenous leukemia (Xie J et al. Oncol Lett, January 2019) |
| Risk and challenges of CML management during pregnancy: looking for a balanced decision (Chelysheva E et al. Eur J Haematol, January 2019) (epub ahead of print) |
Twins with two different personalities: STAT5B but nocht STAT5A has a key role in BCR/ABL-induced leukemia (Kollmann S et al. Leukemia, January 2019) (epub ahead of print) |
