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Please find below a selection of interesting articles on CML from peer-reviewed journals. Recent publications include:
Clinical Publications:
- How to manage CML patients with comorbidities
(Cortes J. Blood, November 2020) – open access publication
- Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia
(Abaza Y et al. Am J Hematol, November 2020) - Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: Updates from the LAST study on patient-reported outcomes and biomarkers for relapse
(Braun TP and Druker BJ. JAMA Oncol, November 2020) - BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analysed by NGS
(Soverini S et al. Leukemia, December 2020) (epub ahead of print) - First-generation vs second-generation tyrosine kinase inhibitors: which is best at diagnosis of chronic-phase chronic myeloid leukemia
(Oehler VG. Hematology Am Soc Hematol Educ Program, December 2020) – open access publication
- Tyrosine kinase inhibitor discontinuation in the management of chronic myeloid leukemia: a critical review of the current practice
(Breccia M et al. Expert Rev Hematol, December 2020) - Efficacy and safety of pioglitazone in a phase 1/2 imatinib discontinuation trial (EDI-PIO) in chronic myeloid leukemia with deep molecular response
(Pagnano KBB et al. Am J Hematol, December 2020) – open access publication
Click here to see summaries of key CML publications provided to you as a special service by the iCMLf in partnership with Springer Healthcare IME
CML Publications 2020
| Clinical Publications | Scientific Publications |
| December 2020 | |
|
Management of chronic myeloid leukemia during pregnancy among patients with tyrosine kinase inhibitor: |
Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients (Schmitz U et al. Cancers (Basel), December 2020) – open access publication |
|
Quality of life and symptom burden with first- and second generation tyrosine kinase inhibitors in patients with chronic-phase chronic myeloid leukemia |
Circadian clock gene Period2 suppresses human chronic myeloid leukemia cell proliferation (Wang N et al. Exp Ther Med, December 2020) – open access publication |
|
Switch from branded to generic imatinib: impact on molecular responses and safety in chronic-phase chronic myeloid leukemia patients |
Targeting of the Alox12-12-HETE in blast crisis chronic myeloid leukemia inhibits leukemia stem/progenitor cell function (Gao S et al. Cancer Manag Res, December 2020) – open access publication |
|
Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for CML: |
Inhibitors targeting STAT5 signaling in myeloid leukemias: New Tetrahydroquinoline derivates with improved antileukemic potential (Prié G et al. ChemMedChem, December 2020) |
|
Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era |
Let-7b regulates the Adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells (Zhou X etc. Leuk Lymphoma, December 2020) |
| Evidence that knock down of GSK-3beta in chronic myelogenous leukemia cells augments IFN-gamma-induced apoptosis (Kauffmann MR et al. Leuk Res, December 2020) |
|
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Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis |
|
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Novel strategies to eradicate resistant cells in chronic myeloid leukemia |
|
| November 2020 | |
| The LEukemia Artificial Intelligence Program (LEAP) in chronic myeloid leukemia in chronic phase: A model to improve patient outcomes (Sasaki K et al. Am J Hematol, November 2020) (epub ahead of print) |
The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase (Manley PW et al. Leuk Res, November 2020) |
| Assessment of outcomes after stopping tyrosine kinase inhibitors among patients with chronic myeloid leukemia: A nonrandomized clinical trial (Atallah E et al. JAMA Oncol, November 2020) (epub ahead of print) |
Characterization of p190 BCR-ABL chronic myeloid leukemia reveals specific signalling pathways and therapeutic targets (Adnan-Awad S et al. Leukemia, November 2020) (epub ahead of print) |
| Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: update form the LAST study on patient-reported outcomes and biomarkers for relapse (Braun TP and Druker BJ. JAMA Oncol, November 2020) (epub ahead of print) |
P19INK4d inhibits proliferation and enhances imatinib efficacy through BCR-ABL signalling pathway in CML (Kuang Y et al. Blood Cells Mol Dis, November 2020) |
| Handling challenging questions in the management of chronic myeloid leukemia: When is it safe to stop tyrosine kinase inhibitors? (Rea D. Blood Adv, November 2020) – open access publication |
AMD1 is required for the maintenance of leukemia stem cells and promotes chronic myeloid leukemic growth (Sari IN et al. Oncogene, November 2020) (epub ahead of print) |
| Increased tumor burden in patients with CML after 36 months of imatinib discontinuation (Diral E et al. Blood, November 2020) |
|
| There is a best duration of deep molecular response for treatment-free remission, but it is patient-specific, and that is the challenge (Ross DM and Hughes TP. Br J Haematol, November 2020) (epub ahead of print) |
|
| Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia (Efficace F et al. Leuk Lymphoma, November 2020) (epub ahead of print) |
|
| Predictors of tyrosine kinase inhibitor adherence trajectories in patients with newly diagnosed chronic myeloid leukemia (Clark SE et al. J Oncol Pharm Pract, November 2020) (epub ahead of print) |
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Standardization of BCR-ABL1 p210 monitoring: From nested to digital PCR |
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| Point: Is there a best duration of deep molecular response to achieve therapy-free remission in chronic myeloid leukemia? (Gale RP and Saglio G. Br J Haematol, November 2020) (epub ahead of print) |
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| A retrospective analysis about frequency of monitoring in Italian chronic myeloid leukemia patients after discontinuation (Dragani M et al. J Clin Med, November 2020) – open access publication |
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| Tyrosine kinase inhibitor treatment discontinuation in CML: patient views (Tromp VNMF et al. Leuk Lymphoma, November 2020) (epub ahead of print) – open access publication |
|
| October 2020 | |
| Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: opinion, evidence and recommendations (Abruzzese E et al. Ther Adv Hematol, October 2020) - open access publication |
Recent advances in BCR-ABL tyrosine kinase inhibitors for overriding T315I mutation (Liu J et al. Chem Biol Drug Des, October 2020) (epub ahead of print) |
| Comparison of droplet digital PCR versus qPCR measurements on the International Scale for the molecular monitoring of chronic myeloid leukemia patients (Cortés AA et al. Mol Diagn Thera, October 2020) |
Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem cell and progenitor cells in AML and CML (Herrmann H et al. Blood Adv October 2020) – open access publication |
| The EUTOS long-term survival score predicts disease-specific mortality and molecular responses among patients with CML in a practice-based cohort (Sato E et al. Cancer Med, October 2020) (epub ahead of print) - open access publication |
Increased expression of TIGIT/CD57 in peripheral blood/bone marrow NK cells in patients with chronic myeloid leukemia (Yao D et al. Biomed Res Int, October 2020) – open access publication |
| Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when and for whom? (Atallah E and Schiffer CA. Haematologica, October 2020) – open access publication |
AMP-activated protein kinase activation primes cytoplasmic translocation and authophagic degradation of the BCR-ABL protein in CML cells (Koyama D et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication |
| Chronic myeloid leukemia, Version 2.2021, NCCN Clinical Practice Guidelines (Deininger MW et al. J Natl. Compr Canc Netw, October 2020) – open access publication |
In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, October 2020) – open access publication |
| Chronic myeloid leukemia in solid organ transplant patients: a case series (Amitai I et al. Int J Hematol, October 2020) (epub ahead of print) |
PD-1 expressing CD56-negative NK cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment (Ishiyama KI et al. Cancer Sci, October 2020) (epub ahead of print) – open access publication |
| Treatment outcomes in chronic myeloid leukemia: Does one size fit all? (Garcia-Horton A and Lipton JH. J Natl Compr Canc Netw, October 2020) – open access publication |
CytoGPS: A large-scale karyotype analysis of CML data (Abrams ZB et al. Cancer Genet, October 2020) (epub ahead of print) |
| Favourable outcome of chronic myeloid leukemia co-expressing e13a2 and e14a2 transcripts, treated with nilotinib (Mulas O et al. Hematol Oncol, October 2020) |
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signalling complex (Gregor T et al. Cell Mol Sci, October 2020) |
| On the road to treatment-free remission in chronic myeloid leukemia: What about ‘the others’? (Stagno F et al. Expert Rev Anticancer Ther, October 2020) (epub ahead of print) |
DYRK2 controls a key regulatory network in chronic myeloid leukemia (Park CS and Lacorazza HD. Exp Mol Med, October 2020) (epub ahead of print) - open access publication |
| Case series of chronic myeloid leukemia patients who maintained deep molecular response (DMR) with very low-dose ponatinib: experience in discontinuing low-dose ponatinib and treatment-free remission (TFR) outcomes (Cohen J et al. Leuk Lymphoma, October 2020) |
Detection of residual disease in CML utilizing genome next generation sequencing reveals persistence of differentiated Ph(+) B cells but not bone marrow/stem progenitors (Karigane D et al. Leuk Lymphoma, October 2020) (epub head of print) |
| Dasatinib treatment long-term results among imatinib-resistant/intolerant patients with chronic phase chronic myeloid leukemia are favourable in daily clinical practice (Zackova D et al. Leuk Lymphoma, October 2020) (epub ahead of print) |
Examination of clinically-derived p210 BCR/ABL1 RhoGEF mutations in a murine model marrow transplantation of CML (Ciccarelli BT et al. Leuk Res, October 2020) |
| September 2020 | |
| Why is it critical to achieve a deep molecular response in chronic myeloid leukemia? (Branford S. Haematologica, September 2020) – open access publication |
CML – Not only BCR-ABL1 matters (Rinke J et al. Best Pract Res Clin Haematol, September 2020) |
| Breakpoints mapping of a t(9;22;12) chronic myeloid leukemia patient with e14a3 BCR-ABL1 transcript using nanopore sequencing (Zhao H et al. J Gene Med, September 2020) (epub ahead of print) |
Declaration of BCR-ABL1 independence (Zhao H and Deininger MW. Leukemia, September 2020) |
| Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia (Shanmunagathan N et al. Blood, September 2020) (epub ahead of print) |
Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells (Tanaka Y et al. Exp Hematol, September 2020) |
| Incidence of deep molecular responses and treatment-free remission in de novo CP-CMO patients (Etienne G et al. Cancers(Basel), September 2020) – open access publication |
Checkpoint kinase-1 inhibitors and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologenous recombination DNA damage repair (Fan Z et al. Oncol Rep, September 2020) (epub ahead of print) - open access publication |
| Erythropoietin treatment in chronic myeloid leukemia patients treated with frontline imatinib who developed anaemia (Cesini L et al. Eur J Hematol, September 2020) |
A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor chronic myeloid leukemia cells (He B et al. Biomed Pharmacother, September 2020) – open access publication |
| Treatment-free remission in chronic myeloid leukemia harbouring atypical BCR-ABL1 transcripts (Dragani M et al. Mediterr J Hematol Infect Dis, September 2020) – open access publication |
BCR-ABL allosteric inhibitors: Where we are and where we are going to (Carofiglio F et al. Molecules, September 2020) – open access publication |
| Unravelling surviving expression in chronic myeloid leukemia: Molecular interactions and clinical implications (Bernardo PS et al. Blood Rev, September 2020) |
|
| Second-line dasatinib therapy improved compliance and deep molecular responses in imatinib-intolerant chronic myeloid leukemia patients (Markovic U et al. Anticancer Res, September 2020) |
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| Impact of the BCR-ABL1 transcript type on clinical and biological parameters and molecular response in patients with chronic myeloid leukemia (Nachi M et al. Hematol Oncol Stem Cell Ther, September 2020) – open access publication |
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| Response and adherence to nilotinib in daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotonib (Boons CCLM et al. Eur J Pharmacol, September 2020) – open access publication |
|
| August 2020 | |
| Moving on from 2013 to 2020 European LeukemiaNet recommendations for treating chronic myeloid leukemia: what has changed over the 7 years? (Yilmaz U & Eskazan AE. Expert Rev Hematol, August 2020) (epub ahead of print) - open access publication |
SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem cell disorders (Kaiser A et al. Leukemia, August 2020 |
| A phase 1 study to evaluate the feasibility and efficacy of the addition of ropeginterferon alpha-2b to imatinib in patients with chronic phase chronic myeloid leukemia (CML) not achieving a deep molecular response (molecular remission 4.5) – AGMT-CML1 (Heibl S et al. Hematol Oncol, August 2020) (epub ahead of print) |
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses (Adnan Awad S et al. Leukemia, August 2020) (epub ahead of print) – open access publication |
| Treatment-free remission in chronic myeloid leukemia: the patient perspective and areas of unmet needs (Sharf G et al. Leukemia, August 2020) – open access publication |
Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML (Toda J et al. Oncogene, August 2020) – open access publication |
| Low-dose tyrosine kinase inhibitors before treatment discontinuation do not repair treatment-free remission in chronic myeloid leukemia patients: Results of a retrospective study (Cayassials E et al. Cancer, August 2020) – open access publication |
A high-content cytokine screen identifies myostatin propeptides as a positive regulator of primitive chronic myeloid leukemia cells (von Palffy S et al. Haematologica, August 2020) – open access publication |
| Epidural myeloid sarcoma a the presenting symptom of chronic myeloid leukemia blast crisis (Slouma M et al. Clin Rheumatol, August 2020) – open access publication |
Nuclear receptors as potential therapeutic targets for myeloid leukemia (Pan P & Chen X. Cells, August 2020) |
| Ponatinib therapy in recurrent Philadelphia chromosome-positive central nervous system leukemia with T315I mutation after Allo-HSCT (He JB et l. Int J Cancer, August 2020) – open access publication |
In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features (Tusa I et al. Target Oncol, August 2020) (epub ahead of print) – open access publication |
| Vascular events may predict the prognosis of patients with chronic myeloid leukemia (Ureshino H & Kamachi K. Int J Hematol, August 2020) – open access publication |
Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia (Greiner L et al. Int J Cancer, August 2020) – open access publication |
| Effect of age and comorbidities on the decline of glomerular filtration rate in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors (Lucijanic M & Krecak I. Int J Hematol, August 2020) – open access publication |
Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis |
| Use of generic imatinib as first-line treatment in patients with chronic myeloid leukemia (CML): the GIMS (Glivec to Imatinib Switch) study) (Genelli M et al. Blood Res, August 2020) (epub ahead of print) – open access publication |
Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis (Liu J et al. Oncol Lett, August 2020) – open access publication |
| Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo (Jyotsana N et al. Ann Hematol, August 2020) – open access publication |
|
| July 2020 | |
| A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukemia (Smith G et al. Br J Haematol, July 2020) (epub ahead of print) – open access publication |
PVR and ICAM-1 on blast crisis CML stem and progenitor cells with TKI resistance confer susceptibility to NK cells (Kim N et al. Cancers (Basel), July 2020) |
|
Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia |
Tyrosine kinase inhibitors induce alternative spliced BCR-ABL (Ins35bp) variant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, July 2020) – open access publication |
| Current treatment options for chronic myeloid leukemia patients failing second-generation tyrosine kinase inhibitors (García-Gutiérrez V & Hernández-Boluda JCC. J Clin Med, July 2020) – open access publication |
Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors (Rothe K et al. Cell Stem Cells, July 2020) (epub ahead of print) |
| Surrogate markers for treatment-free remission in patients with chronic myeloid leukemia (Ureshino H et al. Clin Lymphoma Myeloma Leuk, July 2020) (epub ahead of print) - open access publication |
Therapeutic inhibition of FcγRIIb signaling targets leukemia stem cells in chronic myeloid leukemia (Parting O et al. Leukemia, July 2020) (epub ahead of print) - open access publication |
| Comparison of BCR-ABL1 quantification in pheripheral blood and bone marrow using an International scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, July 2020) – open access publication |
Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells (Hallal R et al. J Cell Mol Med, July 2020) (epub ahead of print) – open access publication |
| Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia (Abaza Y et al. Am J Hematol, July 2020) (epub ahead of print) |
Targeting SKP2/BCR-ABL pathway with Diosmetin suppresses chronic myeloid leukemia proliferation (Liu Y et al. Eur J Pharmacol, July 2020) (epub ahead of print) |
| Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity (Janssen L et al. Haematologica, July 2020) |
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| Late molecular recurrences in patients with chronic myeloid leukemia experiencing treatment-free remission (Rousselot P et al. Blood Adv, July 2020) – open access publication |
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| Another set of guidelines for chronic myeloid leukaemia (Clark RE. Br J Haematol, July 2020) (epub ahead of print) |
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| Evidence of BCR-ABL1-positive progenitor spread in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML) (Turhan AG et al. Leuk Lymphoma, July 2020) |
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| Platelet function in patients with chronic myeloid leukemia treated with asciminib (Nesr G et al. Leuk Lymphoma, July 2020) (epub ahead of print) |
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| Timing for allogeneic hematopoietic cell transplantation (alloHCT) for chronic myeloid leukemia (CML) patients (Hu B et al. Leuk Lymphoma, July 2020) (epub ahead of print) |
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| June 2020 | |
| The EUTOS long-term survival (ELTS) score is superior to the Sokol score for predicting survival in chronic myeloid leukemia (Pfirrmann M et al. Leukemia, June 2020) (epub ahead of print) - open access publication |
An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TK et al. Blood, June 2020) (epub ahead of print) |
| First-line imatinib vs second- and third-generation TKI’s for chronic phase CML: a systematic review and data analysis (Vener C et al. Blood Adv, June 2020) – open access publication |
Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression (Sloma I et al. Haematologica, June 2020) (epub ahead of print) - open access publication |
| Influence of major BCR-ABL1 transcript subtype on outcomes in patients with chronic myeloid leukemia in chronic phase treated frontline with nilotinib (Gentham A et al. Oncotarget, June 2020) – open access publication |
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitation and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia (Losson H et al. Pharmacol Res, June 2020) (epub ahead of print) |
| Current strategies and future directions to achieve deep molecular response and treatment-free remission in chronic myeloid leukemia (Annunziata M et al. Front Oncol, June 2020) – open access publication |
Micro RNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2 mediated autophagy (Li YL et al. Hum Cell, July 2020) |
| Chronic myeloid leukemia prognosis and therapy: Criticisms and perspectives (Russo D et al. J Clin Med, June 2020) – open access publication |
Inhibition of USP1, a new partner of BCR-ABL, results in decrease of BCR-ABL level in K562 cells (Antonenko SV et al. Exp Oncol June 2020) |
| Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study (Hochhaus A et al. Leukemia, June 2020) (epub ahead of print) - open access publication |
Blastic transformation of BCR-ABL1 positive chronic myeloid leukemia through acquisition of CBFB-MYH11 and mutant KIT (Shoumariyeh K et al. B J Haematol, June 2020) (epub ahead of print) -open access publication |
| How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis from the monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, June 2020) – open access publication |
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| Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia (Pagani IS et al. Leuk Lymphoma, June 2020) (epub ahead of print) |
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| The clinical impact of time to response in de Novo accelerated-phase chronic myeloid leukemia (Ohanian M et al. Am J Hematol, June 2020) (epub ahead of print) |
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| May 2020 | |
| Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors (Hochhaus A et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis (Tang Z et al. Mod Pathol, May 2020) (epub ahead of print) |
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High-risk additional chromosomal abnormalities at low blast counts herald death by CML |
Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: Recent advances (Cumbo C et al. Cancer Manag Res, May 2020) – open access publication |
| Analysis of chronic myeloid leukemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission (Machova Polakova K et al. Leukemia, May 2020) (epub ahead of print) |
Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication |
| Delayed resistance to imatinib after 16 years of therapy in a patient with chronic myeloid leukemia (Kaur U et al. Br J Haematol, May 2020) (epub ahead of print) - open access publication |
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells (Lernoux M et al. Clin Epigenetics, May 2020) – open access publication |
| Prolonged treatment-free remission in chronic myeloid leukemia patients with previous BCR-ABL1 kinase domain mutations (Claudiadini S et al. Haematologica, May 2020) (epub ahead of print) - open access publication |
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia (Joshi SK. Leukemia, May 2020) (epub ahead of print) - open access publication |
| Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the last ten years (Dulucq S et al. Br J Haematol, May 2020) – open access publication |
Coexistance of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in CML: A case report (Shi XB et al. World J Clin Cases, May 2020) – open access publication |
| Treatment-free remission in patients with chronic myeloid leukemia (Ross DM and Hughes TP. Nat Rev Clin Oncol, May 2020) (epub ahead of print) |
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia (Yu C et al. Haematologica, May 2020) – open access publication |
| Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis (Wang Q et al. Leuk Lymphoma, May 2020) |
Recruiting TP53 to target chronic myeloid leukemia stem cells Grant S. Haematologica, May 2020 – open access publication http://www.haematologica.org/content/105/5/1172 |
| ABL genomic editing sufficiently abolished oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo (Chen SH et al. Cancers (Basel), May 2020) – open access publication |
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| Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (Ma CC et al. J Int Med Res, May 2020) – open access publication |
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| High-risk additional chromosomal abnormalities at low blast counts herald death by CML (Hehlmann R et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
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| Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts (Petiti J et al. J Clin Med, May 2020) – open access publication |
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| Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia (Kumar R et al. Leukemia, May 2020) (epub ahead of print) - open access publication |
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| Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis (Xiao FY et al. Life Sci, May 2020) – open access publication |
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| Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia (MA CC et al. J Int Med Res, May 2020) – open access publication |
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| April 2020 | |
| Response and resistance to BCR-ABL1-targeted therapies (Braun TP et al. Cancer Cell, April 2020) |
Nobiletin promotes megakaryocytic differentiation through the MAPK/ERK-dependent EGR1 expression and exerts anti-leukemic effects in human chronic myeloid leukemia (CML) K562 cells (Yen JH et al. Cells, April 2020) – open access publication |
| Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased killer cells (Irani YD et al. Br J Haemaol, April 2020) (epub ahead of print) – open access publication |
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR-ABL/AKT/mTOR pathway (Zhang Z et al. Int J Mol Med, April 2020) |
| Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia (Brümmendorf TH et al. Ann Hematol, April 2020) (epub ahead of print) - open access publication |
Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia (Gong Z et al. Br J Haematol, April 2020) (epub ahead of print) - open access publication |
| Venetoclax and BCR-ABL tyrosine kinase inhibitor combinations: outcome in patients with Philadelphia chromosome-positive advanced myeloid leukemias (Maiti A et al. Acta Haematol, April 2020) (epub ahead of print) |
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemia stem cells in CML (Lin H et al. Blood, April 2020) (epub ahead of print) |
| Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study (Cortes JE et al. Leukemia, April 2020) (epub ahead of print) – open access publication |
Response and resistance to BCR-ABL-1 targeted therapies (Braun TP et al. Cancer Cell, April 2020) |
| Metabolic analysis of patients with chronic myeloid leukemia and cardiovascular adverse events after treatment with tyrosine kinase inhibitors (Caocci et al. J Clin Med, April 2020) – open access publication |
GZD824 as a FLT3, FGFR1 and PDGFR-alpha inhibitor against leukemia in vitro and in vivo (Wang Y et al. Transl Oncol, April 2020) (epub ahead of print) - open access publication |
| Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring (Jabbour E and Kantarjian H. Am J Hematol, April 2020) (epub ahead of print) |
Basic knowledge on BCR-ABL1-positive extracellular vesicles (Jurj A et al. Biomark Med, April 2020) (epub ahead of print) |
| Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic-phase chronic myeloid leukemia based on early achievement of deep molecular response (MR4.5): The phase 2, multicenter N-Road study (Nishiwaki K et al. Cancer Med, April 2020) (epub ahead of print) - open access publication |
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients (Spiess D et al. Ann Hematol, April 2020) (epub ahead of print) – open access publication |
| The differentiated diagnosis of basophilia in patients undergoing BCR-ABL testing (Smith CJ et al. Am J Hematol, April 2020) (epub ahead of print) - open access publication |
A novel chimeric antigen receptor redirecting T-cell specificity towards CCD26+ cancer cells (Zhou S et al. Leukemia, April 2020) (epub ahead of print) |
| Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia (Hino M et al. Int J Hematol, April 2020) (epub ahead of print) |
TKIs induce alternative spliced BCR-ABLIns35bp variant via inhibition of RNA polymerase II on genomic BCR-ABL (Yuda J et al. Cancer Sci, April 2020) (epub ahead of print) - open access publication |
| How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment? A retrospective analysis frontline monitoring registries of the Italian Medicines Agency (AIFA) (Breccia M et al. Cancer Med, April 2020) (epub ahead of print) - open access publication |
Induction of CML-specific immune response through cross-presentation triggered by CTP-mediated BCR-ABL-derived peptides (Yang H et al. Cancer Lett, April 2020) (epub ahead of print) |
| Synthesis and characterization of Telmisartan-derived cell death modulators to circumvent imatinib resistance in chronic myeloid leukemia (Gust R et al. ChemMedChem, April 2020) (epub ahead of print) - open access publication |
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| Role of DNA damage response in suppressing malignant progression of chronic myeloid leukemia and Polycythemia Vera: Impact of different oncogenes (Stetka J et al. Cancers (Basel), April 2020) – open access publication |
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| March 2020 | |
| TARGET: a survey of real-world management of chronic myeloid leukemia across 33 countries (Turkina A et al. Br J Haematol, March 2020) (epub ahead of publication) |
Correction of Bcl-x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse model (Zhang J et al. Br J Haematol, March 2020) (epub ahead of print) |
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Risk stratification of chronic myeloid leukemia according to different prognostic scores |
An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia (Ko TH et al. Blood, March 2020) (epub ahead of print) |
| Patient-initiated discontinuation of tyrosine kinase inhibitor for chronic myeloid leukemia (Langabeer SE et al. Case Rep Hematol, March 2020) – open access publication |
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and –resistant chronic myeloid leukemia cells (Jiang L et al. Eur J Pharmacol, March 2020) (epub ahead of print) – open access publication |
| European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia (Hochhaus A et al. Leukemia, March 2020) (epub ahead of print) – open access publication |
Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells (Shibata N et al. Oncogene, March 2020) (epub ahead of print) |
| Pharmacokinetics of dasatinib in hemodialysis patient with chronic myeloid leukemia and chronic kidney disease (Mori J et al. Int J Hematol, March 2019) (epub ahead of print) |
SIRT7: an influence factor in healthy aging and the development of age-dependet myeloid stem cell disorders |
| Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the new TARGET study 2nd line (Sakurai M et al. Int J Hematol, March 2020) (epub ahead of print) |
Ponatinib induces vascular toxicity through the Notch-1 signaling pathway (Madonna R et al. J Clin Med, March 2020) – open access publication |
| The multi-tyrosine kinase inhibitor ponatinib for chronic myeloid leukemia: Real-world data (Luciano L et al. Eur J Haematol, March 2020) (epub ahead of print)- open access publication |
Involvement of MCL-1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315l(+) Ph+leukemia cells (Inoue C et al. Biochem Biophys Res Commun, March 2020) (epub ahead of print) |
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Novel therapeutic approaches in chronic myeloid leukemia |
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Experience of living with chronic myeloid leukemia and adhering to tyrosine kinase inhibitors: A thematic synthesis of qualitative studies |
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BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia |
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| Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia (Eskazan AE. Leukemia, March 2020) (epub ahead of print) |
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| Does patient sex play a role in treatment-free remission in chronic myeoid leukemia? (Ureshino H et al. Int J Hematol, March 2020) (epub ahead of print) |
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| Significance of lymphocyte count, monocyte count, and lymphocyte-to-monocyte ratio in predicting molecular response in patients with chronic myeloid leukemia: A single center experience (Pepedil-Tanrikulu F et al. Clin Lab, March 2020) |
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| Influence of proton pump inhibitors and H2-receptor antagonists on the efficacy and safety of dasatinib in chronic myeloid leukemia patients (Koutake Y et al. Int J Hematol, March 2020) (epub ahead of print) |
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| February 2020 | |
| Side-effect profile and outcomes of ponatinib in the treatment of chronic myeloid leukemia (Chan O et al. Blood Adv, February 2020) – open access publication |
Phosphorylation-dependent differences in CXCR4-LASP-AKT1 interaction between breast cancer and chronic myeloid leukemia (Butt E et al. Cells, February 2020) – open access publication |
| Prospects of achieving treatment-free remission in chronic myeloid leukemia) (Saglio G et al. Br J Haematol, February 2020) (epub ahead of print) - open access publication |
Aberrant RAG-mediated recombination contributes in lymphoid blast crisis of chronic myeloid leukemia (Thomson DW et al. Leukemia, February 2020) (epub ahead of print) |
| Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the past ten years (Dulucq S et al. Br J Hematol, February 2020) (epub ahead of print) |
Model-based inference and classification of immunological control mechanism from TKI cessation and dose reduction in CML patients (Hähnel T et al. Cancer Res, February 2020) (epub ahead of print) |
| Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results analysis (Wang Q et al. Leuk Lymphoma, January 2020) (epub ahead of print) |
Comparison of BCR-ABL 1 quantification in peripheral blood and bone marrow using an international scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (Greiner G et al. Clin Chem Lab Med, February 2020) (epub ahead of print) |
| Mechanisms of cardiovascular toxicity of BCR-ABL 1 tyrosine kinase inhibitors in chronic myelogenous leukemia (Gustafson D et al. Curr Hematol Rep, February 2020) (epub ahead of print) |
Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia (Huang W et al. Leukemia, February 2020) (epub ahead of print) - open access publication |
| A single center evaluation of cost savings related to treatment-free remission in chronic myeloid leukemia patients: the prerequisites of a pharmaco-economy larger study (Etienne G et al. Br J Haematol, February 2020) (epub ahead of print) |
SRSF1 mediates cytokine induced impaired imatinib sensitivity in chronic myeloid leukemia (Sinnakannu JK et al. Leukemia, February 2020) (epub ahead of print) |
| Novel illumine-based next generation sequencing approach with one-round amplification provides early and reliable detection of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia (Romzova M et al. Br J Hematol, February 2020) (epub ahead of print) |
Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia (Adnan Awad S et al. Blood Adv, February 2020) – open access publication |
| What’s NEXT for CML-NGS mutation screening? (Shanmunagathan N et al. Blood, February 2020) |
The landscape of BCR-ABL mutations in patients with Philadelphia chromosome-positive leukaemias in the era of second-generation tyrosine kinase inhibitors |
| DNA damage and DNA damage response in chronic myeloid leukemia (Popp HD et al. Int J Mol Sci, February 2020) – open access publication |
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Nanomaterials as magic bullets in the treatment of leukemia |
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| January 2020 | |
| Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia (Masarova L et al. Cancer, January 2020) (epub ahead of print) |
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin SCT/TAL-1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication |
| Long-term results of frontline dasatinib in chronic myeloid leukemia (Maiti A et al. Cancer, January 2020) (epub ahead of print) |
How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study (Zhang H et al. J Biomol Strat Dyn January 2020) |
| Molecular dynamics during reduction of TKI dose reliably identify molecular recurrence after treatment cessation of CML (Gottschalk A et al. Blood, January 2020) (epub ahead of print) |
Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukemia patients stopping tyrosine kinase inhibitor therapy |
A randomized phase II trial of hydroxychloroquine and imatinib alone for patients with chronic myeloid leukemia in major cytogenetic response with residual disease |
The leukemia stem cell: similarities, differences and clinical prospects in CML and AML (Vetrie D et al. Nat Rev Cancer, January 2020) (epub ahead of print) |
| Treatment patterns and deep molecular response in chronic-phase – chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study (Cortes J et al. Leuk Lymphoma, January 2020) |
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy (Kinstrie R et al. Leukemia, January 2020) (epub ahead of print) |
| What are the considerations for tyrosine kinase inhibitor discontinuation in chronic phase chronic myeloid leukemia? (Harrington P et al. Expert Rev Hematol, January 2020) (epub ahead of print) |
Knock-out of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance (Herrmann AD et al. J Cell Mol Med, January 2020) (epub ahead of print) – open access publication |
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Successful planned pregnancy through vitrified-warmed embryo transfer in a women with chronic myeloid leukemia: Case report and literature review |
Defining the niche interactions to target chronic myeloid leukemia stem cells (Mitchell R et al. Haematologica, January 2020) – open access publication |
| Treatment-free remission after first-line dasatinib treatment in patients with chronic myeloid leukemia in the chronic phase: the D-NewS study of the Kanto CL Study Group (Yamaguchi H et al. Int J Hematol, January 2020) (epub ahead of print) |
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin – SCL/TAL1 – CD44 axis (Godavarthy PS et al. Haematologica, January 2020) – open access publication |
| Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells (Grandjenette C et al. Cancer Lett, January 2020) |
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