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Please find below a selection of interesting articles on CML from peer-reviewed journals. Recent publications include:

Clinical Publications:   

  • A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukemia
    (Smith G et al. Br J Haematol, July 2020) (epub ahead of print)
    – open access publication
  • Moving on from 2013 to 2020 European LeukemiaNet recommendations for treating chronic myeloid leukemia: what has changed over the 7 years?
    (Yilmaz U & Eskazan AE. Expert Rev Hematol, August 2020) (epub ahead of print)
    - open access publication
  • A phase 1 study to evaluate the feasibility and efficacy of the addition of ropeginterferon alpha-2b to imatinib in patients with chronic phase chronic myeloid leukemia (CML) not achieving a deep molecular response (molecular remission 4.5) – AGMT-CML1
    (Heibl S et al. Hematol Oncol, August 2020) (epub ahead of print)
  • Treatment-free remission in chronic myeloid leukemia: the patient perspective and areas of unmet needs
    (Sharf G et al. Leukemia, August 2020) – open access publication

Scientific publications:

  • RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses
    (Adnan Awad S et al. Leukemia, August 2020) (epub ahead of print)
    – open access publication
  • Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML
    (Toda J et al. Oncogene, August 2020) – open access publication

Pediatric publications

Click here to see summaries of key CML publications provided to you as a special service by the iCMLf in partnership with Springer Healthcare IME

CML Publications 2020 ​

Clinical Publications Scientific Publications
August 2020
Low-dose tyrosine kinase inhibitors before treatment discontinuation do not repair treatment-free remission in chronic myeloid leukemia patients: Results of a retrospective study
(Cayassials E et al. Cancer, August 2020)
– open access publication 
A high-content cytokine screen identifies myostatin propeptides as a positive regulator of primitive chronic myeloid leukemia cells
(von Palffy S et al. Haematologica, August 2020) – open access publication
Epidural myeloid sarcoma a the presenting symptom of chronic myeloid leukemia blast crisis
(Slouma M et al. Clin Rheumatol, August 2020) – open access publication
Nuclear receptors as potential therapeutic targets for myeloid leukemia
(Pan P & Chen X. Cells, August 2020)
Ponatinib therapy in recurrent Philadelphia chromosome-positive central nervous system leukemia with T315I mutation after Allo-HSCT
(He JB et l. Int J Cancer, August 2020)
– open access publication
In vitro comparison of the effects of imatinib and ponatinib on chronic myeloid leukemia progenitor/stem cell features
(Tusa I et al. Target Oncol, August 2020)
(epub ahead of print)
– open access publication
Vascular events may predict the prognosis of patients with chronic myeloid leukemia
(Ureshino H & Kamachi K. Int J Hematol, August 2020)
– open access publication
Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia
(Greiner L et al. Int J Cancer, August 2020)
– open access publication
Effect of age and comorbidities on the decline of glomerular filtration rate in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors
(Lucijanic M & Krecak I. Int J Hematol, August 2020)
– open access publication

Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis
(Liu J et al. Oncol Lett, August 2020)
– open access publication

Use of generic imatinib as first-line treatment in patients with chronic myeloid leukemia (CML): the GIMS (Glivec to Imatinib Switch) study)
(Genelli M et al. Blood Res, August 2020) (epub ahead of print)
– open access publication
Mutations in the BCR-ABL1 kinase domain in patients with chronic myeloid leukemia treated with TKIs or at diagnosis
(Liu J et al. Oncol Lett, August 2020)
– open access publication
  Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo
(Jyotsana N et al. Ann Hematol, August 2020)
– open access publication
July 2020

Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia
(Abecasis M et al. Leukemia, July 2020)
– open access publication

Tyrosine kinase inhibitors induce alternative spliced BCR-ABL (Ins35bp) variant via inhibition of RNA polymerase II on genomic BCR-ABL
(Yuda J et al. Cancer Sci, July 2020)
– open access publication
Current treatment options for chronic myeloid leukemia patients failing second-generation tyrosine kinase inhibitors
(García-Gutiérrez V & Hernández-Boluda JCC. J Clin Med, July 2020)
– open access publication
Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors
(Rothe K et al. Cell Stem Cells, July 2020)
(epub ahead of print)  
Surrogate markers for treatment-free remission in patients with chronic myeloid leukemia
(Ureshino H et al. Clin Lymphoma Myeloma Leuk, July 2020) (epub ahead of print)
- open access publication
Therapeutic inhibition of FcγRIIb signaling targets leukemia stem cells in chronic myeloid leukemia
(Parting O et al. Leukemia, July 2020)
(epub ahead of print)
- open access publication 
Comparison of BCR-ABL1 quantification in pheripheral blood and bone marrow using an International scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia
(Greiner G et al. Clin Chem Lab Med, July 2020) – open access publication
Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells
(Hallal R et al. J Cell Mol Med, July 2020)
(epub ahead of print)
– open access publication 
Phase I/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia
(Abaza Y et al. Am J Hematol, July 2020) (epub ahead of print)
Targeting SKP2/BCR-ABL pathway with Diosmetin suppresses chronic myeloid leukemia proliferation
(Liu Y et al. Eur J Pharmacol, July 2020)
(epub ahead of print)
Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity
(Janssen L et al. Haematologica, July 2020)
PVR and ICAM-1 on blast crisis CML stem and progenitor cells with TKI resistance confer susceptibility to NK cells
(Kim N et al. Cancers (Basel), July 2020)
Late molecular recurrences in patients with chronic myeloid leukemia experiencing treatment-free remission
(Rousselot P et al. Blood Adv, July 2020)
– open access publication
 
Another set of guidelines for chronic myeloid leukaemia
(Clark RE. Br J Haematol, July 2020)
(epub ahead of print)
 
Evidence of BCR-ABL1-positive progenitor spread in blood during molecular recurrence after TKI discontinuation in chronic myeloid leukemia (CML)
(Turhan AG et al. Leuk Lymphoma, July 2020)
 
Platelet function in patients with chronic myeloid leukemia treated with asciminib
(Nesr G et al. Leuk Lymphoma, July 2020)
(epub ahead of print)
 
Timing for allogeneic hematopoietic cell transplantation (alloHCT) for chronic myeloid leukemia (CML) patients
(Hu B et al. Leuk Lymphoma, July 2020)
(epub ahead of print)
 
June 2020
The EUTOS long-term survival (ELTS) score is superior to the Sokol score for predicting survival in chronic myeloid leukemia
(Pfirrmann M et al. Leukemia, June 2020) (epub ahead of print)
- open access publication
An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia
(Ko TK et al. Blood, June 2020)
(epub ahead of print)  
First-line imatinib vs second- and third-generation TKI’s for chronic phase CML:
a systematic review and data analysis
(Vener C et al. Blood Adv, June 2020)
– open access publication
Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression
(Sloma I et al. Haematologica, June 2020)
(epub ahead of print)
- open access publication 
Influence of major BCR-ABL1 transcript subtype on outcomes in patients with chronic myeloid leukemia in chronic phase treated frontline with nilotinib
(Gentham A et al. Oncotarget, June 2020) – open access publication
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitation and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia
(Losson H et al. Pharmacol Res, June 2020)
(epub ahead of print
Current strategies and future directions to achieve deep molecular response and treatment-free remission in chronic myeloid leukemia
(Annunziata M et al. Front Oncol, June 2020)
– open access publication
Micro RNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2 mediated autophagy
(Li YL et al. Hum Cell, July 2020)
Chronic myeloid leukemia prognosis and therapy: Criticisms and perspectives
(Russo D et al. J Clin Med, June 2020)
– open access publication
Inhibition of USP1, a new partner of BCR-ABL, results in decrease of BCR-ABL level in K562 cells
(Antonenko SV et al. Exp Oncol June 2020)
Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study
(Hochhaus A et al. Leukemia, June 2020)
(epub ahead of print)
- open access publication
Blastic transformation of BCR-ABL1 positive chronic myeloid leukemia through acquisition of CBFB-MYH11 and mutant KIT
(Shoumariyeh K et al. B J Haematol, June 2020)
(epub ahead of print)
-open access publication
How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment?
A retrospective analysis from the monitoring registries of the Italian Medicines Agency (AIFA)
(Breccia M et al. Cancer Med, June 2020)
– open access publication
 
Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia
(Pagani IS et al. Leuk Lymphoma, June 2020)
(epub ahead of print)
 
The clinical impact of time to response in de Novo accelerated-phase chronic myeloid leukemia
(Ohanian M et al. Am J Hematol, June 2020)
(epub ahead of print)
 
May 2020
Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors
(Hochhaus A et al. Leukemia, May 2020) (epub ahead of print)
- open access publication
Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis
(Tang Z et al. Mod Pathol, May 2020)
(epub ahead of print)  

High-risk additional chromosomal abnormalities at low blast counts herald death by CML
(Hehlmann R et al. Leukemia, May 2020) (epub ahead of print)
– open access publication

Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: Recent advances
(Cumbo C et al. Cancer Manag Res, May 2020)
– open access publication 
Analysis of chronic myeloid leukemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission
(Machova Polakova K et al. Leukemia, May 2020) (epub ahead of print)
Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts
(Petiti J et al. J Clin Med, May 2020)
– open access publication  
Delayed resistance to imatinib after 16 years of therapy in a patient with chronic myeloid leukemia
(Kaur U et al. Br J Haematol, May 2020)
(epub ahead of print)
- open access publication
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells
(Lernoux M et al. Clin Epigenetics, May 2020)
– open access publication
Prolonged treatment-free remission in chronic myeloid leukemia patients with previous BCR-ABL1 kinase domain mutations
(Claudiadini S et al. Haematologica, May 2020)
(epub ahead of print)
- open access publication
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia
(Joshi SK. Leukemia, May 2020) (epub ahead of print)
- open access publication
Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the last ten years
(Dulucq S et al. Br J Haematol, May 2020)
– open access publication
Coexistance of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in CML: A case report
(Shi XB et al. World J Clin Cases, May 2020)
– open access publication
Treatment-free remission in patients with chronic myeloid leukemia
(Ross DM and Hughes TP. Nat Rev Clin Oncol, May 2020) (epub ahead of print)
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
(Yu C et al. Haematologica, May 2020)
– open access publication
Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results (SEER) analysis
(Wang Q et al. Leuk Lymphoma, May 2020)
Recruiting TP53 to target chronic myeloid leukemia stem cells
Grant S. Haematologica, May 2020 – open access publication
http://www.haematologica.org/content/105/5/1172
  ABL genomic editing sufficiently abolished oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo
(Chen SH et al. Cancers (Basel), May 2020)
– open access publication
  Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia
(Ma CC et al. J Int Med Res, May 2020)
– open access publication
  High-risk additional chromosomal abnormalities at low blast counts herald death by CML
(Hehlmann R et al. Leukemia, May 2020)
(epub ahead of print) - open access publication
  Novel multiplex droplet digital PCR assays to monitor minimal residual disease in chronic myeloid leukemia patients showing atypical BCR-ABL1 transcripts
(Petiti J et al. J Clin Med, May 2020) – open access publication
  Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia
(Kumar R et al. Leukemia, May 2020)
(epub ahead of print) - open access publication

Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis
(Xiao FY et al. Life Sci, May 2020)
– open access publication 
  Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia
(MA CC et al. J Int Med Res, May 2020)
– open access publication 
April 2020
Response and resistance to BCR-ABL1-targeted therapies
(Braun TP et al. Cancer Cell, April 2020)
Nobiletin promotes megakaryocytic differentiation through the MAPK/ERK-dependent EGR1 expression and exerts anti-leukemic effects in human chronic myeloid leukemia (CML) K562 cells
(Yen JH et al. Cells, April 2020)
– open access publication 
Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased killer cells
(Irani YD et al. Br J Haemaol, April 2020)
(epub ahead of print)
– open access publication
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR-ABL/AKT/mTOR pathway
(Zhang Z et al. Int J Mol Med, April 2020
Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia
(Brümmendorf TH et al. Ann Hematol, April 2020)
(epub ahead of print)
- open access publication
Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia
(Gong Z et al. Br J Haematol, April 2020)
(epub ahead of print)
- open access publication
Venetoclax and BCR-ABL tyrosine kinase inhibitor combinations: outcome in patients with Philadelphia chromosome-positive advanced myeloid leukemias
(Maiti A et al. Acta Haematol, April 2020)
(epub ahead of print)
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemia
stem cells in CML (Lin H et al. Blood, April 2020)
(epub ahead of print
Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study
(Cortes JE et al. Leukemia, April 2020)
(epub ahead of print)
– open access publication
Response and resistance to BCR-ABL-1 targeted therapies
(Braun TP et al. Cancer Cell, April 2020
Metabolic analysis of patients with chronic myeloid leukemia and cardiovascular adverse events after treatment with tyrosine kinase inhibitors
(Caocci et al. J Clin Med, April 2020)
– open access publication
GZD824 as a FLT3, FGFR1 and PDGFR-alpha inhibitor against leukemia in vitro and in vivo
(Wang Y et al. Transl Oncol, April 2020)
(epub ahead of print)
- open access publication 
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring
(Jabbour E and Kantarjian H. Am J Hematol, April 2020) (epub ahead of print)
Basic knowledge on BCR-ABL1-positive extracellular vesicles
(Jurj A et al. Biomark Med, April 2020)
(epub ahead of print
Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic-phase chronic myeloid leukemia based on early achievement of deep molecular response (MR4.5): The phase 2, multicenter N-Road study
(Nishiwaki K et al. Cancer Med, April 2020)
(epub ahead of print)
- open access publication 
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients
(Spiess D et al. Ann Hematol, April 2020)
(epub ahead of print)
– open access publication
The differentiated diagnosis of basophilia in patients undergoing BCR-ABL testing
(Smith CJ et al. Am J Hematol, April 2020)
(epub ahead of print)
- open access publication 
A novel chimeric antigen receptor redirecting T-cell specificity towards CCD26+ cancer cells
(Zhou S et al. Leukemia, April 2020) (epub ahead of print)
Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia
(Hino M et al. Int J Hematol, April 2020)
(epub ahead of print
TKIs induce alternative spliced BCR-ABLIns35bp variant via inhibition of RNA polymerase II on genomic BCR-ABL
(Yuda J et al. Cancer Sci, April 2020) (epub ahead of print)
- open access publication
How many chronic myeloid leukemia patients who started a frontline second-generation tyrosine kinase inhibitor have to switch to a second-line treatment?
A retrospective analysis frontline monitoring registries of the Italian Medicines Agency (AIFA)
(Breccia M et al. Cancer Med, April 2020)
(epub ahead of print)
- open access publication
Induction of CML-specific immune response through cross-presentation triggered by CTP-mediated BCR-ABL-derived peptides
(Yang H et al. Cancer Lett, April 2020) (epub ahead of print)
  Synthesis and characterization of Telmisartan-derived cell death modulators to circumvent imatinib resistance in chronic myeloid leukemia
(Gust R et al. ChemMedChem, April 2020) (epub ahead of print)
- open access publication
  Role of DNA damage response in suppressing malignant progression of chronic myeloid leukemia and Polycythemia Vera: Impact of different oncogenes
(Stetka J et al. Cancers (Basel), April 2020)
– open access publication
March 2020
TARGET: a survey of real-world management of chronic myeloid leukemia across 33 countries
(Turkina A et al. Br J Haematol, March 2020)
(epub ahead of publication)
Correction of Bcl-x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse model
(Zhang J et al. Br J Haematol, March 2020)
(epub ahead of print)

Risk stratification of chronic myeloid leukemia according to different prognostic scores
(Aijaz J et al. Cureus, March 2020)
– open access publication

An integrative model of pathway convergence in genetically heterogenous blast crisis chronic myeloid leukemia
(Ko TH et al. Blood, March 2020) (epub ahead of print
Patient-initiated discontinuation of tyrosine kinase inhibitor for chronic myeloid leukemia
(Langabeer SE et al. Case Rep Hematol, March 2020)
– open access publication
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and –resistant chronic myeloid leukemia cells
(Jiang L et al. Eur J Pharmacol, March 2020)
(epub ahead of print)
open access publication  
European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia
(Hochhaus A et al. Leukemia, March 2020)
(epub ahead of print)open access publication
Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells
(Shibata N et al. Oncogene, March 2020)
(epub ahead of print
Pharmacokinetics of dasatinib in hemodialysis patient with chronic myeloid leukemia and chronic kidney disease
(Mori J et al. Int J Hematol, March 2019)
(epub ahead of print)

SIRT7: an influence factor in healthy aging and the development of age-dependet myeloid stem cell disorders
(Kaiser A et al. Leukemia, March 2020)
(epub ahead of print)

 
Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the new TARGET study 2nd line
(Sakurai M et al. Int J Hematol, March 2020)
(epub ahead of print)
Ponatinib induces vascular toxicity through the Notch-1 signaling pathway
(Madonna R et al. J Clin Med, March 2020)
open access publication
The multi-tyrosine kinase inhibitor ponatinib for chronic myeloid leukemia: Real-world data
(Luciano L et al. Eur J Haematol, March 2020)
(epub ahead of print)- open access publication
Involvement of MCL-1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315l(+) Ph+leukemia cells
(Inoue C et al. Biochem Biophys Res Commun, March 2020) (epub ahead of print)

Novel therapeutic approaches in chronic myeloid leukemia
(Özgür Y et al. Leuk, February 2020)
(epub ahead of print)

 

Experience of living with chronic myeloid leukemia and adhering to tyrosine kinase inhibitors: A thematic synthesis of qualitative studies
(Hewison A et al. Eur J Oncol Nurs, February 2020)
open access publication

 

 

BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia
(Cai Z et al. J Cancer, February 2020)
open access publication

 
Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia
(Eskazan AE. Leukemia, March 2020)
(epub ahead of print)

 

 
Does patient sex play a role in treatment-free remission in chronic myeoid leukemia?
(Ureshino H et al. Int J Hematol, March 2020)
(epub ahead of print)
 
Significance of lymphocyte count, monocyte count, and lymphocyte-to-monocyte ratio in predicting molecular response in patients with chronic myeloid leukemia: A single center experience
(Pepedil-Tanrikulu F et al. Clin Lab, March 2020)
 
Influence of proton pump inhibitors and H2-receptor antagonists on the efficacy and safety of dasatinib in chronic myeloid leukemia patients
(Koutake Y et al. Int J Hematol, March 2020)
(epub ahead of print)
 
February 2020
Side-effect profile and outcomes of ponatinib in the treatment of chronic myeloid leukemia
(Chan O et al. Blood Adv, February 2020)
– open access publication 
Phosphorylation-dependent differences in CXCR4-LASP-AKT1 interaction between breast cancer and chronic myeloid leukemia
(Butt E et al. Cells, February 2020)
open access publication
Prospects of achieving treatment-free remission in chronic myeloid leukemia)
(Saglio G et al. Br J Haematol, February 2020)
(epub ahead of print)
- open access publication
Aberrant RAG-mediated recombination contributes in lymphoid blast crisis of chronic myeloid leukemia
(Thomson DW et al. Leukemia, February 2020)
(epub ahead of print
Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia patients: a systematic review of literature with a meta-analysis of studies over the past ten years
(Dulucq S et al. Br J Hematol, February 2020)
(epub ahead of print)
Model-based inference and classification of immunological control mechanism from TKI cessation and dose reduction in CML patients
(Hähnel T et al. Cancer Res, February 2020)
(epub ahead of print
Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: a surveillance, epidemiology and end results analysis
(Wang Q et al. Leuk Lymphoma, January 2020)
(epub ahead of print)
Comparison of BCR-ABL 1 quantification in peripheral blood and bone marrow using an international scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia
(Greiner G et al. Clin Chem Lab Med, February 2020)
(epub ahead of print
Mechanisms of cardiovascular toxicity of BCR-ABL 1 tyrosine kinase inhibitors in chronic myelogenous leukemia
(Gustafson D et al. Curr Hematol Rep, February 2020)
(epub ahead of print)
Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia
(Huang W et al. Leukemia, February 2020)
(epub ahead of print)
- open access publication
A single center evaluation of cost savings related to treatment-free remission in chronic myeloid leukemia patients: the prerequisites of a pharmaco-economy larger study
(Etienne G et al. Br J Haematol, February 2020)
(epub ahead of print
SRSF1 mediates cytokine induced impaired imatinib sensitivity in chronic myeloid leukemia
(Sinnakannu JK et al. Leukemia, February 2020)
(epub ahead of print)
Novel illumine-based next generation sequencing approach with one-round amplification provides early and reliable detection of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia
(Romzova M et al. Br J Hematol, February 2020)
(epub ahead of print
Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia
(Adnan Awad S et al. Blood Adv, February 2020)
– open access publication
What’s NEXT for CML-NGS mutation screening?
(Shanmunagathan N et al. Blood, February 2020)

The landscape of BCR-ABL mutations in patients with Philadelphia chromosome-positive leukaemias in the era of second-generation tyrosine kinase inhibitors
(Chien SH et al. Hematol Oncol, February 2020)
(epub ahead of print)

 
  DNA damage and DNA damage response in chronic myeloid leukemia
(Popp HD et al. Int J Mol Sci, February 2020)
– open access publication
 

Nanomaterials as magic bullets in the treatment of leukemia
(Houshmand M et al. Nanomaterials (Basel), February 2020)
open access publication

January 2020
Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia
(Masarova L et al. Cancer, January 2020) (epub ahead of print)
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin SCT/TAL-1 – CD44 axis
(Godavarthy PS et al. Haematologica, January 2020)
– open access publication 
Long-term results of frontline dasatinib in chronic myeloid leukemia
(Maiti A et al. Cancer, January 2020)
(epub ahead of print)
How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study
(Zhang H et al. J Biomol Strat Dyn January 2020
Molecular dynamics during reduction of TKI dose reliably identify molecular recurrence after treatment cessation of CML
(Gottschalk A et al. Blood, January 2020)
(epub ahead of print)  

Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukemia patients stopping tyrosine kinase inhibitor therapy
(Söderlund S et al. Leuk Res, January 2020)
(epub ahead of print)


A randomized phase II trial of hydroxychloroquine and imatinib alone for patients with chronic myeloid leukemia in major cytogenetic response with residual disease
(Horne GA et al. Leukemia, January 2020)
(epub ahead of print) 

The leukemia stem cell: similarities, differences and clinical prospects in CML and AML
(Vetrie D et al. Nat Rev Cancer, January 2020)
(epub ahead of print)
Treatment patterns and deep molecular response in chronic-phase – chronic myeloid leukemia patients treated with second-line nilotinib or dasatinib: a multi-country retrospective chart review study
(Cortes J et al. Leuk Lymphoma, January 2020
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
(Kinstrie R et al. Leukemia, January 2020)
(epub ahead of print)
What are the considerations for tyrosine kinase inhibitor discontinuation in chronic phase chronic myeloid leukemia?
(Harrington P et al. Expert Rev Hematol, January 2020)
(epub ahead of print)
Knock-out of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance
(Herrmann AD et al. J Cell Mol Med, January 2020)
(epub ahead of print)
– open access publication

Successful planned pregnancy through vitrified-warmed embryo transfer in a women with chronic myeloid leukemia: Case report and literature review
(Furukawa Y et al. Mediterr J Hematol Infect Dis, January 2020) – open access publication

Defining the niche interactions to target chronic myeloid leukemia stem cells
(Mitchell R et al. Haematologica, January 2020)
– open access publication
Treatment-free remission after first-line dasatinib treatment in patients with chronic myeloid leukemia in the chronic phase: the D-NewS study of the Kanto CL Study Group
(Yamaguchi H et al. Int J Hematol, January 2020)
(epub ahead of print)
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin – SCL/TAL1 – CD44 axis
(Godavarthy PS et al. Haematologica, January 2020)
– open access publication
  Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells
(Grandjenette C et al. Cancer Lett, January 2020)


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