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  • Michele Baccarani
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1 year 5 months ago
Dasatinib, L asperginase and pancreatitis

Michele Baccarani

I think that both drugs have already been stopped. I would never resume l-asparaginase, I would resume Dasatinib 50 mg daily, as soon as pancreatic enzymes and ultrasonography will be normal.

Good luck and best wishes!

  • AK Tripathi
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1 year 5 months ago
Dasatinib, L asperginase and pancreatitis

I had two patients who were on dasatinib and L asparginase during induction phase of B ALL treatment develop acute pancreatitis. Is it likely that dasatinib enhances the chance of developing acute pancreatitis if also on L asparginase?

For clarity, both patients developed symptoms such as severe abdominal pain, had abnormal pancreatic enzymes and positive ultrasonography.

Case 1 is 13 yrs female, B-ALL Ph+; case 2 is 46 yrs female, B-ALL Ph+.

The pancreatitis developed during induction in both patients.

Coagulation tests were within normal range in both patients.