ICMLf Genomics Alliance -
Goals and accomplishments through a global collaboration

Professor Susan Branford
Centre for Cancer Biology & SA Pathology, Adelaide, Australia

Table of contents:

• 0:00 Introduction
• 0:19 Genomic profiling using next-generation sequencing (NGS)
• 01:23 Acquired drug resistance is a mutation driven process in CML
• 03:11 NGS: Cancer-related genes detected in patients with CML
• 03:20 The International CML Genomics Alliance
• 04:52 Established a clinical need for genomics
• 05:43 Frequency of mutations in cancer genes identified in ≥1 patient
• 07:34 Studies of highly selected patients at diagnosis using NGS
• 10:13 Studies of patients in AP/BP
• 12:09 Prognostic relevance of genetic abnormalities in blast phase
• 12:58 What we know / what we don't know
• 14:12 Partnering with the HARMONY Big Data Project
• 15:33 Clonal hierarchy in CML
• 19:20 Unmet need for patients with cancer gene mutations

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