2025 ELN recommendations on the management of CML

Professor Jane Apperley
Imperial College, London (UK)

Background:
The European LeukemiaNet (ELN) has issued expert consensus recommendations for managing CML since 2006, with updates in 2009, 2013, and 2020. The 2025 version, recently accepted for publication in Leukemia, reflects evolving clinical data, new therapies, and a growing emphasis on individualised care.
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Table of contents:

• ELN recommendations: process (00:40)
• Defining disease phase in CML - including new WHO criteria for defining disease phase in CML (04:14)
• Prognosis at diagnosis - including impact of ASXL1 mutation at diagnosis (10:58)
• Monitoring response to treatment (17:43)
• Response milestones 2025 - including 'Why personalise the milestones?' (19:08)
• First-line treatment - including first-line treatment with asciminib (31:32)
• Resistance (36:20)
• Treatment-free remission (38:14)
• Parenting - including pregnancy outcomes and planning a pregnancy in established CML (39:22)
• Adverse events (42:33)

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