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Jorge Cortes, MD
Professor of Medicine
Chief, CML Section
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, Texas
Jorge Cortes, MD, is deputy chair and professor of medicine in the Department of Leukemia at The University of Texas MD Anderson Cancer Center, Houston Texas where he directs the CML Program. Dr. Cortes received his medical degree in 1986 from the Universidad Nacional Autonoma de Mexico, Mexico City, and has been at MD Anderson Cancer Center since 1991. Dr. Cortes, whose clinical interest focus on new drug development and the management of patients with myelodysplastic syndromes, acute and chronic leukemias, and myeloproliferative disorders has authored over 400 peer-reviewed medical publications. He has received numerous awards including the Faculty Scholar Award from MD Anderson Cancer Center in 2003, the Annual Celgene Young Investigator Achievement Award for Clinical Research in Hematology in 2005, The Dr. John J. Kenny Award from The Leukemia & Lymphoma Society in 2006, the Service to Mankind Award from The Leukemia & Lymphoma Society in 2007, and the Otis W. and Pearl L. Walters Faculty Achievement Award in Clinical Research from MD Anderson Cancer Center in 2007. Dr. Cortes is chief editor of Current Hematological Malignancies Reports and Clinical Leukemia and serves in the Editorial Board of the Journal of Clinical Oncology, Leukemia, Clinical Cancer Research, Leukemia and Lymphoma and the American Journal of Hematology.
Francisco Cervantes
Francisco Cervantes is senior consultant at the Hematology Department of the Hospital Clínic, in Barcelona, Spain, and associate professor at the University of Barcelona. His main scientific interest is the study of chronic myeloid leukemia (CML) and the Ph-negative chronic myeloproliferative neoplasms (MPNs), mainly their natural history, prognosis, biology, and treatment. As a result of the activity in this field, he has published more than 190 articles in peer-review international journals, including the New England Journal of Medicine, Blood, Journal of Clinical Oncology, Leukemia, British Journal of Haematology, Experimental Hematology, Haematologica, Cancer, Oncogene, Seminars in Oncology, and the European Journal of Haematology. In the CML field,Dr. Cervantes contributed to the elaboration of Sokal’s score, is a coauthor of the publications of the IRIS study, which established imatinib as first-line treatment for CML, has participated in the introduction of the second-generation tyrosine kinase inhibitors for patients resistant to imatinib, as well as in the authorship of the European LeukemiaNet recommendations for the treatment of CML. His more recent contributions in the field of the MPNs have been the elaboration of the new prognostic classification of primary myelofibrosis on behalf of the International Working Group for Myelofibrosis Research and Treatment, as well as several studies on the role of leukocyte and platelet activation in the thrombosis of MPN patients. At local level, he is the national coordinator of the CML studies within the collaborative PETHEMA Spanish group. Dr Cervantes is a member of the American Society of Hematology, the European Hematology Association, the International Working Group for Myeloproliferative Neoplasms Research and Treatment, the European Leukemianet, and the Spanish Society of Hematology.
Brian J. Druker, MD
Dr. Druker is director of the OHSU Knight Cancer Institute, JELD-WEN Chair of Leukemia Research at Oregon Health & Science University, and investigator of the Howard Hughes Medical Institute. Upon graduating from the University of California, San Diego School of Medicine in 1981, Dr. Druker completed his internship and residency in internal medicine at Barnes Hospital, Washington School of Medicine in St. Louis, Missouri. He then trained in oncology at Harvard's Dana-Farber Cancer Institute.
Dr. Druker then returned to the lab to begin his research career studying the regulation of the growth of cancer cells and the practical application to cancer therapies. He developed 4G10, an anti-phosphotyrosine antibody that was an essential reagent to scientists at Novartis in their kinase inhibitor drug discovery program. In collaboration with Novartis, his laboratory performed pre-clinical studies that were instrumental to the development of Gleevec (imatinib), a drug that targets the molecular defect in chronic myeloid leukemia (CML). After completing a series of preclinical studies, Dr. Druker spearheaded the highly successful clinical trials of imatinib for CML. Imatinib is currently FDA approved for CML, gastrointestinal stromal tumors (GIST) and five other cancers.
His role in the development of imatinib and its application in the clinic have resulted in numerous awards for Dr. Druker, including the AACR-Richard and Hinda Rosenthal Award, the Warren Alpert Prize from Harvard Medical School, the American Society of Hematology's Dameshek Prize, the Lance Armstrong Foundation's Pioneer of Survivorship Carpe Diem Award, the American Cancer Society's Medal of Honor, the Kettering Prize from General Motors Cancer Research Foundation, the David A. Karnofsky Award from the American Society of Clinical Oncology, the Robert-Koch Award, and the 2009 Lasker-DeBakey Award for Clinical Medical Research. He was elected to the Institute of Medicine of the National Academies in 2003, the American Association of Physicians in 2006, and the National Academy of Sciences in 2007.
Pat Garcia-Gonzalez
Pat Garcia-Gonzalez
Executive Director, The Max Foundation
Pat Garcia-Gonzalez, Executive Director of The Max Foundation, has been dedicated to improving the lives of blood cancer survivors around the world for over twelve years. A native of Argentina, Pat has a Master degree from the University of Washington and technical degree in nursing.
Pat is co-founder of The Max Foundation, an international NGO based in Edmonds, Washington, started in 1997 to connect families facing leukemia with resources for treatment access.
Under Pat's direction since 2005, The Max Foundation provides services to over 15,000 CML patients in more than 90 countries annually and has successfully started and supported local patient organizations in 12 countries.
In 2008, Pat was awarded the distinguished honor of the Golden Tennis Shoe Award from United States Senator, Patty Murray for her service and dedication to her community. She is a member of the Global Health Council and of the CML Advocates Network.
Tessa Holyoake
Professor Tessa Holyoake
- 1980-85 Medicine Glasgow University
- 1985-86 House jobs Stobhill and Victoria, Glasgow
- 1986-89 General medical training Inverclyde Hospital, Greenock
- 1989-92 Haematology, Western Infirmary, Glasgow
- 1992-96 PhD, Beatson Institute for Cancer Research, Glasgow
- Specialist Haematology Training, Glasgow Royal Infirmary
- 1996-98 LRF Senior Lecturer, Terry Fox Labs, Vancouver
- 1999-2001 Senior Lecturer, Academic Transfusion Medicine Unit, Glasgow Royal Infirmary
- 2001-2004 Reader, Section of Experimental Haematology, Glasgow Royal
- 2004-present Professor, Section of Experimental Haematology, Glasgow Royal
- 2008 Relocation of Section of Experimental Haematology to the Paul O'Gorman Leukaemia Research Centre and West of Scotland Cancer Centre, Gartnavel Hospital
Research Interests
My research focuses on the cancer stem cell. Cancer stem cells sustain cancers and leukaemias, are inherently resistant to many cancer therapies, including novel targeted agents and ultimately cause relapse in patients following therapy. We are most interested in the blood cancers, in particular chronic myeloid leukaemia. We have developed laboratory methods to purify the cells of interest from leukaemia patients and from normal donors, allowing side by side comparisons of leukaemic versus normal stem cells. These comparisons include global analyses of gene expression and protein expression. Any differences can then be fully investigated and exploited through drug discovery. Recently we have begun to explore high throughput drug screening against the purified cancer stem cells hoping to find drugs that rapidly kill the cancer stem cells but leave normal stem cells intact.
On the clinical side I run clinical trials of novel agents for patients with CML Scotland wide.
Giuseppe Saglio, M.D
Professor of Internal Medicine
Department of Clinical and Biological Sciences
University of Turin
Turin, Italy
Dr Giuseppe Saglio is Professor of Internal Medicine and Haematology at the University of Turin. He is Director of the Department of Clinical and Biological Sciences at the University of Turin and responsible for the Division of Internal Medicine and Haematology at San Luigi University Hospital. He graduated from the University of Turin in 1975. Since then he has studied Internal Medicine at the University of Turin (1975-1980), Haematology at the University of Milan (1980-1983) and Molecular Biology at the University of Leiden (1976), Inserm-Creteil, Paris (1979) and the University of California (1983).
Dr Saglio is co-ordinator of the PhD programme in Molecular Medicine and Experimental Therapy at the University of Turin, past-president of the Italian Society of Experimental Haematology (SIES) and general secretary of the IACRLRD (International Association for Comparative Research on Leukemia and Related Diseases). He has published more than 500 peer-reviewed articles in the fields of molecular pathogenesis of haematological malignancies (1986-present), molecular medicine applied to clinical medicine (1978-present) and the molecular basis of thalassemia and related haemoglobinopathies (1978-1990).
Hemant Malhotra
Prof. Dr. Hemant Malhotra, MD, FRCP (London), FRCP (Edinburgh), FACP (USA), MNAMS, FICP, FUICC, FIMSA
Professor & Head, Department of Medical Oncology, Sriram Cancer Center, Mahatma Gandhi Medical College Hospital, Jaipur.
Dr. Hemant Malhotra is presently Professor & Head, Department of Medical Oncology at the Sriram Cancer Center of the Mahatma Gandhi College Hospital, Jaipur. Since superannuating after more than three decades of government service where he was the PHOD, Department of Medicine and Head of the division of Medical Oncology at the Birla Cancer Center, SMS Medical College, Jaipur, he now working full time at the MGMCH. The Mahatma Gandhi Medical College Hospital is 1400 bedded, one of the leading tertiary care teaching and patient care center of North India, and the largest in the private sector.
Dr. Malhotra graduated and post-graduated at the top of his batch from the SMS Medical College and after fellowships at Tata Memorial Cancer Center, Mumbai (1989 to 1991); Cornell Medical Center, New York and Memorial Sloan Kettering Cancer Center, New York, set up the Medical Oncology division in the department of Medicine at the SMS Hospital in 1991, the first in the state of Rajasthan. He also established a Bone Marrow Transplantation Unit at the SMS and his team has successfully done the first-ever autologous bone marrow transplantation in the state of Rajasthan. Regular autologous and allogeneic Stem Cell Transplantations are now being done in the unit.
Dr. Malhotra has more than three decades of treating cancer patients in the state of Rajasthan is a well-recognized and respected teacher. Many of his students are now senior medical oncologists spread all over the country and heading their own departments.
He is an internationally and nationally recognized medical oncologist and was the India, Pakistan & Bangladesh representative to the European Society for Medical Oncology (ESMO) from 2006 to 2008. He is also ESMO board certified in medical oncology. He is an advisor/consultant/referee/committee member for oncology to several Government of India bodies and head the ICMR committee for formulation of guidelines for multiple myeloma. He serves on the Specialty Expert Committee on Hematology & Oncology of the Drug Controller General of India. He has served on the National Oncology SAE Committee of the Drug Controller General of India, Government of India. He has been an invited consultant to the WHO on guideline development for bio-similar oncology molecules.
Dr. Malhotra has to his credit more than 200 international and national publications and presentations and is an office bearer and member of many international and national societies and organizations. He is the lead author of a chapter on Chronic Leukemia in the Oxford Text book of Oncology. He is the Immediate Past President of the Indian Society of Medical & Pediatric Oncology (ISMPO). He is one of the founder members & Head of
the Hematological Cancers Committee of the Indian Cooperative Oncology Network (ICON).
Dr. Malhotra is keenly interested in clinical research and has completed more than 40 investigator initiated and industry sponsored pivotal clinical trial as Principal Investigator. Dr. Malhotra has investigator-initiated trials and projects in several diseases, especially Chronic Myeloid Leukemia. He is also on the Board of Advisors of the International CML Foundation and is the national representative to the iCMLf from India. Dr. Malhotra has been the Joint Secretary of the Ethic Committee of the SMS Medical College since inception till 2010 and has been instrumental in drafting the SOPs of the EC. He has also been a Member of the Ethics Committee at the Bhagwan Mahaveer Cancer Hospital in Jaipur.
Amongst his recent honors, Dr. Malhotra was awarded the International Chronic Myeloid Leukemia Prize for outstanding work in CML in emerging regions in Miami, USA in 2018. He was also invited to Chair and speak at the 62nd Annual Conference of the American Society of Hematology (ASH) organized at Orlando, USA in the first week of December 2019, the only physicians from the whole country to be give this honor.
