As part of our monthly news service we would like to make you aware of the CML publications of the month. From the many papers published every month Professor Timothy Hughes has selected topical, interesting papers for your perusal that also include interesting publications on pediatric CML.

Read Professor Hughes' CML publications of the month: June 2025

Clinical CML papers

• Five-year molecular response and overall survival with first- and second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia in the chronic-phase: A prospective, observational study – SIMPLICITY
  Mauro MJ et al. Leuk Lymphoma, June 2025 (epub ahead of print)
  – open access publication
• Which is the best tyrosine kinase inhibitor for newly diagnosed chronic myelogenous leukemia? - Review
  Shanmunagathan N et al. Am Soc Clin Oncol Educ Book, June 2025 – open access publication
• Asciminib for Philadelphia chromosome-positive leukemias
  Hughes TP et al. Haematologica, June 2025 (epub ahead of print) – open access publication
• Treatment-free remission in chronic myeloid leukemia: Revisiting the “W” questions
  Bruzzese A et al. Eur J Haematol, June 2025 (epub ahead of print) – open access publication
• SOHO state of the art updates and next questions: Combination therapy in chronic myeloid leukemia chronic-phase – Review
  Costa A and Breccia M. Clin Lymphoma Myeloma Leuk, June 2025
• Impact of tyrosine kinase inhibitors on thyroid function in chronic myeloid leukemia: A systematic review
  Sardarova N et al. Cureus, June 2025 – open access publication
• Olverembatinib in chronic myeloid leukemia: Is less actually better?
  Perusini MA and Kim DDH. Haematologica, June 2025 (epub ahead of print) – open access publication
• Real-world evidence of treatment-free remission strategies and outcomes in chronic myeloid leukemia
  Bourne G et al. Cancers(Basel), June 2025 – open access publication
• Innovative rapid screening for complex BCR-ABL kinase domain mutations in TKI-treated leukemia patients
  Lan Y et al. Br J Cancer, June 2025 (epub ahead of print)
• Ponatinib may make allogeneic hematopoietic stem cell transplantation unnecessary for CML-BC under conditions, such as the de novo cases: 
  A case series of the novo CML-BC treated with ponatonib and no transplantation
  Koyabu S et al. Leuk Lymphoma, June 2025
• The efficacy and safety of asciminib treatment in patients with chronic myeloid leukemia as a second-line or beyond second-line treatment: A systematic review and meta analysis
  Fan Z et al. Ther Adv Hematol, June 2025 – open access publication
• Treatment-free remission (TFR) in chronic-phase chronic myeloid leukemia 
  (CP-CML): Analysis of predictive factors and novel baseline scoring system to predict molecular relapse
  Laganà A et al Eur J Haematol, June 2025 (epub ahead of print)

Scientific CML papers

• BCR-ABL: The mastermind behind chronic myeloid leukemia – Review
  Shammas T et al. Cytokine Growth Factor Rev, June 2025 – open access publication
• SUMOylation facilitates the stability of BCR-ABL to promote chronic myeloid leukemia progression
  Zhang L et al. Oncogene, June 2025
• Metabolomic profiling and bioanalysis of chronic myeloid leukemia: Identifiying biomarker for treatment response and disease monitoring
  Sayin S et al. Metabolite, June 2025 – open access publication
• SMYD3 activates fatty acid beta-oxidation to promote self-renewal of leukemia stem cells
  Zhou M et al. Cancer Res, June 2025
• Genetic variants in oxidative stress-related genes and their impact on prognosis and treatment response in chronic myeloid leukemia patients
  Alves R et al. Int J Mol, June 2025 – open access publication

Pediatric CML papers

• Rare manifestations of pediatric chronic myeloid leukemia: A case report on priapism and a literature review
  Budair R et al. Front Oncol, June 2025 – open access publication
• Quality of life and adherence to tyrosine kinase inhibitors among pediatric, adolescent, and young adult chronic myeloid leukemia patients: A systematic Review
  Werk RS et al. Pediatr Blood Cancer, June 2025 – open access publication