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Query blast crisis?

  • Saurabh Bhave
  • Saurabh Bhave's Avatar Topic Author
5 years 5 months ago #1676 by Saurabh Bhave
Query blast crisis? was created by Saurabh Bhave
We have a young male with muscle lesion which on biopsy is CML.
He is CML in CP on BM studies.
Cytogenetics: no other abnormalities other than PH chromosome

Is extramedullary CML (without any increase in blasts) be considered as blast crisis?

  • Giuseppe Saglio
  • Giuseppe Saglio's Avatar Topic Author
5 years 5 months ago - 5 years 5 months ago #1677 by Giuseppe Saglio
Replied by Giuseppe Saglio on topic Query blast crisis?
To answer this question I have to go back to the opinion of John Goldman (as well as of other experts); extra-medullary CML has to be considered a progression and transformation of CML similar to blast crisis, in particular if the patient was already in TKI therapy. Is this the case?
Yours, Beppe Saglio
Last edit: 5 years 5 months ago by Nicola.
  • jeff lipton
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5 years 5 months ago - 5 years 5 months ago #1678 by jeff lipton
Replied by jeff lipton on topic Query blast crisis?
Agree with Bepe. If this is extramedullary disease, it should be considered like blast crisis. Would consider radiating the lesion and if otherwise responding to TKI, go to allografting in a young person
Last edit: 5 years 5 months ago by Nicola.
Moderators: Nicolaarlene