Translate page

× To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML patient cases here. Clinicians submit a brief history of the patient and the case for discussion (no more than 200 words) by posting it in this forum ("+ NEW TOPIC" button below).

Each clinical case will be forwarded to the iCMLf expert clinical panel for a brief independent response. Consideration should be given to patient confidentiality. Details that are not critical to the case can be changed to preserve anonymity.

As a full clinical history is necessary for accurate comment, cases and comments on the Forum are only accepted from clinicians. If individual patients have a specific question we encourage them to contact their healthcare provider.

DISCLAIMER: The iCMLf does not recommend or endorse any specific tests, physicians, products, procedures, or opinions, and disclaims any representation, warranty, or guaranty as to the same. Reliance on any information provided in this Forum is solely at your own risk.

Dasatinib, L asperginase and pancreatitis

  • AK Tripathi
  • AK Tripathi's Avatar Topic Author
1 month 1 week ago - 1 month 1 day ago #1840 by AK Tripathi
Dasatinib, L asperginase and pancreatitis was created by AK Tripathi
I had two patients who were on dasatinib and L asparginase during induction phase of B ALL treatment develop acute pancreatitis. Is it likely that dasatinib enhances the chance of developing acute pancreatitis if also on L asparginase?

For clarity, both patients developed symptoms such as severe abdominal pain, had abnormal pancreatic enzymes and positive ultrasonography.

Case 1 is 13 yrs female, B-ALL Ph+; case 2 is 46 yrs female, B-ALL Ph+.

The pancreatitis developed during induction in both patients.

Coagulation tests were within normal range in both patients.
Last edit: 1 month 1 day ago by arlene.
  • Michele Baccarani
  • Michele Baccarani's Avatar Topic Author
1 month 1 day ago - 1 month 1 day ago #1844 by Michele Baccarani
Replied by Michele Baccarani on topic Dasatinib, L asperginase and pancreatitis
Michele Baccarani

I think that both drugs have already been stopped. I would never resume l-asparaginase, I would resume Dasatinib 50 mg daily, as soon as pancreatic enzymes and ultrasonography will be normal.

Good luck and best wishes!
Last edit: 1 month 1 day ago by arlene.
Moderators: Melissa Davis-Bishop