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Dasatinib, L asperginase and pancreatitis

  • AK Tripathi
  • AK Tripathi's Avatar Topic Author
2 years 11 months ago - 2 years 11 months ago #1840 by AK Tripathi
Dasatinib, L asperginase and pancreatitis was created by AK Tripathi
I had two patients who were on dasatinib and L asparginase during induction phase of B ALL treatment develop acute pancreatitis. Is it likely that dasatinib enhances the chance of developing acute pancreatitis if also on L asparginase?

For clarity, both patients developed symptoms such as severe abdominal pain, had abnormal pancreatic enzymes and positive ultrasonography.

Case 1 is 13 yrs female, B-ALL Ph+; case 2 is 46 yrs female, B-ALL Ph+.

The pancreatitis developed during induction in both patients.

Coagulation tests were within normal range in both patients.
Last edit: 2 years 11 months ago by arlene.
  • Michele Baccarani
  • Michele Baccarani's Avatar Topic Author
2 years 11 months ago - 2 years 11 months ago #1844 by Michele Baccarani
Replied by Michele Baccarani on topic Dasatinib, L asperginase and pancreatitis
Michele Baccarani

I think that both drugs have already been stopped. I would never resume l-asparaginase, I would resume Dasatinib 50 mg daily, as soon as pancreatic enzymes and ultrasonography will be normal.

Good luck and best wishes!
Last edit: 2 years 11 months ago by arlene.
Moderators: Nicolaarlene