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× To share and enhance best practice management of CML, experts and interested clinicians can discuss difficult or interesting CML cases here. Clinicians submit a brief history of the patient and the case for discussion (no more than 200 words) by posting it in this forum ("+ NEW TOPIC" button below). Please include the country of origin.

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Poor CML response to imatinib, dasatinib

  • Michele Baccarani
  • Michele Baccarani's Avatar
9 years 3 months ago #273 by Michele Baccarani
Replied by Michele Baccarani on topic Re: Poor CML response to imatinib, dasatinib
I believe that in any resistant, and particularly unusual, case, it is very important to know more. More tests require more money, but never as much as a wrong treatment decision. And forgetting money, a wrong treatment decision is not good for the patient. Therefore I confirm that a bone marrow examination, cytology, histopathology, and karyotype, would help. And I confirm that in the meantime I would test again imatinib, full dose.

Regards, Michele Baccarani
  • johnmgoldman
  • johnmgoldman's Avatar
9 years 3 months ago #275 by johnmgoldman
Replied by johnmgoldman on topic Re: Poor CML response to imatinib, dasatinib
I would probably repeat all relevant examinations, then switch to nilotinib. Ponatinb can indeed also be considered. SCT is third option, as you suggest

John Goldman

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