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CML intolerant/resistant to all TKIs

9 years 3 months ago #250 by
Some additional information: He has no detectable BCR-ABL mutation. He has been on TKI therapy without interruptions, at reduced doses of the TKIs because of the cytopenias (dasatinib 100mg then 70mg a day; nilotinib 300mg BID then 150 mg BID; bosutinib 300mg a day; ponatinib 15 mg a day.)
David Snyder
  • Pankaj Malhotra
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9 years 3 months ago #251 by Pankaj Malhotra
Replied by Pankaj Malhotra on topic Re: CML intolerant/resistant to all TKIs
This additional information is very useful. Information on bone marrow cellularity, number of blasts, presence of myelofibrosis and type of BCR ABL transcripts and presence of any co-morbidities in the patient would be highly appreciated.
9 years 3 months ago - 9 years 3 months ago #253 by Trey
Some patients require significant dose reduction for pancytopenia when the issue is multi-drug intolerance. For instance, some patients have responded to dosage as low as 20mg dasatinib, which has allowed continuous drug therapy and also marrow recovery. Dr Cortes at MDA can consult on this.

CML Patient Advocate
Last edit: 9 years 3 months ago by Nicola. Reason: Qualification
Moderators: Melissa Davis-Bishop