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News
Session Summaries from the 67th ASH Annual Meeting
December 2025 - We're bringing you highlights from the 67th ASH Annual Meeting with a summary of selected scientific sessions on CML
🌟 Oral Abstract Session: CML clinical & epidemiological -
Decoding the molecular drivers of response and resistance
Chairs: Sin Tiong Ong (Singapore) -
Naranie Shanmunagathan (Adelaide)
This session highlighted advances in understanding why patients with CML either respond well to TKIs, relapse after stopping therapy, or develop treatment failure. Across six presentations, scientists used genomic profiling, single-cell sequencing, transcriptomics, machine learning, clonal evolution studies, and integrated DNA/RNA MRD monitoring to decode mechanisms of resistance, relapse, and biological heterogeneity.
Key themes included ASXL1-driven risk, LSC signatures predicting relapse, genomic variants at diagnosis, AI-based TFR prediction, the distinct biology of minor BCR::ABL1, and DNA-based minimal residual disease (MRD) monitoring for safer TKI de-escalation.
Our key takeaways from the presentations:
Getting ready for ASH 2025 - Plan your CML Sessions
November 2025 - Only a few weeks to go until the 67th Annual Meeting of the American Society of Hematology (ASH). This year, the meeting takes place in Orlando, Florida, and online from 6th-9th December.
With a record-breaking number of abstracts submitted and more than 8,200 accepted, this premier event in hematology promises a wealth of exciting updates – including many important new insights into CML.
To help you plan your schedule, we have compiled a list of key CML sessions. These include an Education Spotlight Session, Oral Abstract Presentations, Poster sessions, and a Friday Satellite Symposium.
Don’t miss the annual iCMLf Forum and the oral presentation of the iCMLf/HARMONY Foundation CML Genomics project among this year’s highlights at ASH.
Have a question or suggestion for the iCMLf? The iCMLf’s Chief Executive, Nicola Evans will be on-site in Orlando. If you’d like to arrange a meeting, please contact us at info@cml-foundation.org.
We look forward to connecting with you at ASH 2025.
iCMLf Forum - Saudi Arabia: Advancing CML Practice Through Global Collaboration
The inaugural iCMLf Forum: Saudi Arabia - Progress and Practice in CML brought together 43 physicians from across the Kingdom and beyond for a full day of evidence-based updates, debate, and clinical discussion in Riyadh. As our first iCMLf Forum delivered outside the United States, this meeting on November 1st 2025 marked an important milestone in strengthening global collaboration around CML management.
Led by Professors Jorge Cortes, Tim Hughes and Giuseppe Saglio, alongside an exceptional Saudi faculty including Professor Naeem Chaudhri, Dr Mohammed Almakadi, Dr Marwan Shaheen and Dr Binyam Usman, the Forum explored the latest science shaping CML management in 2025.
Session Summaries from the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy
October 2025 - We're bringing you highlights from the recent ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy with a summary of selected scientific sessions.
🌟 Scientific Session: Stem Cells 🌟
Chair: Mary Scott (Glasgow)
This session explored new insights into leukemic stem cell biology, persistence, and the bone marrow microenvironment in CML. The speakers presented novel models and molecular mechanisms driving stem cell survival and relapse, highlighting inflammatory, metabolic, and stromal interactions shaping disease behaviour and treatment-free remission (TFR) potential.
Our key takeaways from the presentations:
2025 John Goldman Fun Run - Thank you for your support!
October 2025 - Thank you to everyone who joined the 2025 John Goldman Run Run, held during the recent ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy in Estoril.
This year’s Run was a huge success!
More than 50 participants set off before sunrise for a 5-km run along the scenic seaside route, proudly wearing this year’s purple Fun Run charity t-shirts.
Together, we raised $2,900 – more funds than ever before – in support of the iCMLf programs that improve access to CML education and care in low- and middle-income countries.
A heartfelt thank you to all our individual supporters.
REMINDER - iCMLf Conversation with Daniela Krause and Jorge Cortes next Wednesday
Recap of ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy on October 22nd at 14.00
October 2025 - Here’s a quick reminder about next week’s iCMLf Conversation – ‘Highlights from ESHCML2025’, taking place on Wednesday, October 22nd.
📅 Date: Wednesday, October 22nd
🕑 Time: 14:00 CEST
🖥️ Format: Live webinar on Zoom
Join Professors Daniela Krause and Jorge Cortes - co-chairs of the ESH–iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy – as they share their personal take on the most exciting biological and clinical highlights from the meeting.
